An experimental study was conducted to explore the possible application of dynamically actuated nanowires to effectively disturb the wall layer in fully developed, turbulent channel flow. Actuated nanowires have the potential to be used for the mixing and filtering of chemicals, enhancing convective heat transfer and reducing drag. The first experimental evidence is presented suggesting it is possible to manipulate and subsequently control turbulent flow structures with active nanowires. An array of rigid, ultra-long (40 μm) TiO2 nanowires was fabricated and installed in the bounding wall of turbulent channel flow then oscillated using an attached piezoelectric actuator. Flow velocity and variance measurements were taken using a single sensor hot-wire with results indicating the nanowire array significantly influenced the flow by increasing the turbulent kinetic energy through the entire wall layer.