Thesis (Ph.D.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves 338-377) Also available in print.

Thesis (Ph. D. in Chemistry)--Vanderbilt University, Dec. 2006. / Title from title screen. Includes bibliographical references.

Thesis (M. Sc.)--University of Canterbury, 2006. / Typescript (photocopy). "July 2006." Includes bibliographical references (leaves 69-72). Also available via the World Wide Web.

Thesis (Ph.D.)--Texas Christian University, 2008. / Title from dissertation title page (viewed Feb. 26, 2009). Includes abstract. Includes bibliographical references.

Kyoto University (京都大学) / 0048 / 新制・課程博士 / 博士(工学) / 甲第17525号 / 工博第3684号 / 新制||工||1560(附属図書館) / 30291 / 京都大学大学院工学研究科分子工学専攻 / (主査)教授 佐藤 啓文, 教授 今堀 博, 教授 山本 量一 / 学位規則第4条第1項該当

M.Sc. / This study deals with the synthesis of nitrogen-donor imidazolyl- and pyrazolyl-salicylaldimine compounds, their reactions with selected transition metals and applications as catalysts for Heck coupling reactions of aryl halides with butyl acrylate, ethylene polymerization reactions and reactions of higher α-olefins. Imidazole-based salicylaldimine compounds 2,4-di-tert-butyl-6-{[2-(1H-imidazol-4-yl)-ethylimino]-methyl}-phenol (L1) and 4-tert-butyl-2-{[2-(1H-imidazole-4-yl)-ethylimino]-methly}-phenol (L2) were prepared by Schiff base condensation reaction of histamine dihydrochloride with 3,5-di-tert-butyl-2-hydroxybenzaldehyde and 5-tert-butyl-2-hydroxybenzaldehyde respectively. The compounds were characterized by 1H, 13C{1H} NMR and IR spectroscopy; and high resolution mass spectrometry (HRMS). Compounds 2-{[2-(1H-imidazole-4-yl)-ethylimino]-methly}-phenol (L3), 2,4-di-tert-butyl-6-{[2-(3,5-dimethyl-pyrazol-1-yl)-ethylimino]-methyl}-phenol (L4), 2,4-di-tert-butyl-6-[(2-pyrazol-1-yl-ethylimino)-methyl]-phenol (L5) and 2,4-di-tert-butyl-6-{[2-(3,5-diphenyl-pyrazol-1-yl)-ethylimino]-methyl}-phenol (L6) were synthesized according to literature procedure. Reactions of L1-L3 with [PdCl2(MeCN)2] yielded complexes 2.1-2.3 respectively. Ligand L1 was also complexed with [FeCl2] and [CoCl2] to give complexes 2.4 and 2.5 respectively, while complexes 2.6-2.15 were synthesized by reactions of L1, L2 and L4-L6 with [VCl3] and [CrCl3(THF)3]; all in a ratio of 1:1. The palladium(II) complexes (2.1-2.3) were characterized by 1H, 13C{1H} NMR and IR spectroscopy, mass spectrometry and elemental analysis, while complexes 2.4-2.15 were characterized by IR spectroscopy, mass spectrometry and elemental analysis due to their paramagnetic nature. The structures of complexes 2.1 and 2.4 were confirmed by single crystal X-ray diffraction analysis. All the complexes formed were mononuclear.

Luminescent transition metal complexes have arisen as viable alternatives to organic dyes for sensory applications due to their notable advantages. This thesis aimed to synthesize different kinds of iridium(III) complexes as chemosensors and G-quadruplex probes for the detection of metal ions, small molecules, proteins and DNA to demonstrate the versatility of iridium(III) complex in luminescence sensing. Iridium(III) complex chemosensors were synthesized and developed for the detection of Cu2+ and cysteine. The iridium(III) complex plays the role of the "signaling unit", which transduces the analyte binding event into an optical (luminescent) signal and the "receptor unit" attached to the metal complex selectively binds the analyte of interest. Meanwhile, a series of iridium(III) complexes incorporating a variety of C^N and N^N donor ligands were synthesized and were shown to exhibit G-quadruplex-selective binding properties via emission titration, fluorescence resonance energy transfer melting and G-quadruplex fluorescent intercalator displacement experiments. These G-quadruplex-selective Ir(III) complexes were utilized as signal transducers to monitor the conformational changes of oligonucleotides in label-free oligonucleotide-based luminescent detection platforms for metal ion (Ag+), small molecules (cocaine), protein (insulin and AGR2) and gene deletion.

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One of the main goals of computational methods is to identify reasonable geometries for target materials. Organometallic complexes have been investigated in this dissertation research, entailing a significant challenge based on transition metal diversity and the associated complexity of the ligands. A large variety of theoretical methods have been employed to determine ground state geometries of organometallic species. An impressive number of transition metals entailing diverse isomers (e.g., geometric, spin, structural and coordination), different coordination numbers, oxidation states and various numbers of electrons in d orbitals have been studied. Moreover, ligands that are single, double or triple bonded to the transition metal, exhibiting diverse electronic and steric effects, have been investigated. In this research, a novel de novo scheme for structural prediction of transition metal complexes was developed, tested and shown to be successful.