Molecular weights of 2,000, 6,000 and 10,000 of silane functionalized atactic polystyrene (aPS) and α,ω-divinyl functionalized polydimethylsiloxane (PDMS) were prepared via living anionic polymerization and bulk anionic ring opening polymerization respectively. Functionalization of the homopolymers was confirmed by FT-IR and 1H-NMR spectroscopy and their molecular weights were determined via 1H-NMR end group analysis. A hydrosilylation reaction between the functionalized homopolymers of different molecular weights produced nine polystyrene-block-polydimethylsiloxane-block-polystyrene (aPS-b-PDMS-b-aPS) triblock copolymers. Field emission scanning electron microscopy observations revealed the copolymers self-assemble into supramolecular structures. Dynamic Light Scattering measurements show only small increase in the order of nanometers of its hydrodynamic radius as the individual molecular weights of the homopolymers were increased. Nanocomposites of the copolymers were prepared by incorporating 1% of oxidized single walled carbon nanotubes (SWNTs) within the aPS-PDMS-aPS matrices via coagulation precipitation. Differential scanning calorimetry (DSC) thermal analysis shows the SWNT interacting with both aPS and PDMS constituting blocks. SWNTs interaction with aPS block either increases the polymer glass transition temperature (Tg) by restricting its segmental motion or decreases the Tg by a plasticization effect. Within the PDMS block the SWNTs act as nucleating sites accelerating the crystallization rate of the polymer. This is evident by the appearance of single and double melting endotherms in the DSC thermograms.

Poly(ethylene oxide)-poly(styrene)-poly(ethylene oxide) triblock copolymer with di-hydroxyl terminated groups (HO-PEO-PS-PEO-OH) was conjugated with nitrilotriacetic acid (NTA) via esterification reaction using N,N'-Dicyclohexylcarbodiimide (DCC), 4-Dimethylaminopyridine (DMAP) and Dimethylformamide (DMF) as a solvent at 80 ○C. The poly(ethylene oxide)-poly(styrene)-poly(ethylene oxide) with NTA end groups (NTA-PEO-PS-PEO-NTA) was characterized and structure confirmed by 1H NMR, 13C NMR, and FT-IR spectroscopies. Thermogravimetric analysis (TGA) was carried out to investigate the thermal stability of the starting triblock copolymer poly(ethylene oxide)-poly(styrene)-poly(ethylene oxide) with di-hydroxyl terminated groups (HO-PEO-PS-PEO-OH) and the conjugated poly(ethylene oxide)-poly(styrene)-poly(ethylene oxide) functional polymer (NTA-PEO-PS-PEO-NTA). Surface morphologies of the (HO-PEO-PS-PEO-OH) and (NTA-PEO-PS-PEO-NTA) were studied by atomic force microscopy. In addition, the size distributions were determined using dynamic light scattering. The thermal behavior of the (HO-PEO-PS-PEO-OH) and (NTA-PEO-PS-PEO-NTA) were examined by differential scanning calorimetry (DSC). DSC thermograms indicate the formation of a two phase polymer matrix. The poly(ethylene oxide)-poly(styrene)-poly(ethylene oxide) with NTA functionalized end groups (NTA-PEO-PS-PEO-NTA) was bound or chelated with Ni(II) metal ion. The binding studies were carried out by ultraviolet-visible (UV-Vis) spectroscopy. The electronic behaviors of PEO-b-PS-b-PEO/ PS/ NTA-PEO-b-PS-b-PEO-NTA with ratio (1/5/1) and PEO-b-PS-b-PEO/ PS/ NTA-PEO-b-PS-b-PEO-NTA-Ni containing 1% of oxidized single-walled carbon nanotubes (SWCNTs) were investigated by I–V plots from Kelvin sensing. The I–V plots before sensitizing with protein varied from the I–V plots after binding with protein indicating that the composites may be used as active components in biosensors.

Abstract: ABC triblock copolymers self-organize into a wide variety of supramolecular structures in the bulk. However, their associative behavior in selective solvents has scarcely been studied. Within the search for new stimuli-responsive supramolecular architectures, our attention focused on a pH-responsive polystyrene-b-poly(2-vinylpyridine)-b-poly(ethylene oxide) (PS-b-P2VP-b-PEO) triblock copolymer. In addition to the synthesis of monodisperse spherical core-shell-corona (CSC) micelles, the reversibility and the cooperativity of the response to pH variations were studied, morphological transitions were induced and multi-responsive micellar gels were prepared. The micellization mechanism, the structure, the responsiveness and the internal organization of these new nanomaterials were investigated using a combination of transmission electronic microscopy, atomic force microscopy, light scattering, small-angle neutron and X-ray scattering, nuclear magnetic resonance and rheology. Finally, efforts were geared towards potential applications. The ability of PS-b-P2VP-b-PEO CSC micelles to encapsulate and release hydrophobic species was probed and gold nanoparticles were successfully synthesized within the P2VP layer of spherical and cylindrical micelles, which acted as nanoreactors./Résumé : Les copolymères triséquencés ABC sauto-organisent et forment une large gamme de structures supramoléculaires en phase solide. Cependant, peu détudes portent sur leur comportement associatif induit par des solvants sélectifs. Dans le cadre de la recherche de nouvelles architectures supramoléculaires sensibles aux stimuli externes, nous avons entrepris létude dun copolymère triséquencé sensible au pH : polystyrène-b-poly(2-vinylpyridine)-b-poly(oxyde déthylène). Outre la synthèse de micelles sphériques de type CSC, le caractère réversible et coopératif de la réponse au pH a été étudié, ainsi que linduction de transitions morphologiques et la préparation de gels micellaires sensibles à la température et au pH. Le mécanisme de micellisation, les paramètres structuraux, la sensibilité aux stimuli ainsi que lorganisation interne de ces nouveaux nanomatériaux ont été étudiés par une combinaison de microscopies électronique à transmission et à force atomique, diffusion lumineuse, diffusion de neutrons et rayons X aux petits angles, résonance magnétique nucléaire et rhéologie. Enfin, des applications ont été envisagées : la capacité des micelles CSC à encapsuler et libérer des composés hydrophobes a été testée et des nanoparticules dor ont été synthétisées avec succès au sein de ces nanoréacteurs, cest-à-dire dans la couche de P2VP des micelles sphériques et cylindriques.

New ABC triblock copolymers were synthesized by controlled free-radical polymerization via Reversible Addition-Fragmentation chain Transfer (RAFT). Compared to amphiphilic diblock copolymers, the prepared materials formed more complex self-assembled structures in water due to three different functional units. Two strategies were followed: The first approach relied on double-thermoresponsive triblock copolymers exhibiting Lower Critical Solution Temperature (LCST) behavior in water. While the first phase transition triggers the self-assembly of triblock copolymers upon heating, the second one allows to modify the self-assembled state. The stepwise self-assembly was followed by turbidimetry, dynamic light scattering (DLS) and 1H NMR spectroscopy as these methods reflect the behavior on the macroscopic, mesoscopic and molecular scale. Although the first phase transition could be easily monitored due to the onset of self-assembly, it was difficult to identify the second phase transition unambiguously as the changes are either marginal or coincide with the slow response of the self-assembled system to relatively fast changes of temperature. The second approach towards advanced polymeric micelles exploited the thermodynamic incompatibility of “triphilic” block copolymers – namely polymers bearing a hydrophilic, a lipophilic and a fluorophilic block – as the driving force for self-assembly in water. The self-assembly of these polymers in water produced polymeric micelles comprising a hydrophilic corona and a microphase-separated micellar core with lipophilic and fluorophilic domains – so called multi-compartment micelles. The association of triblock copolymers in water was studied by 1H NMR spectroscopy, DLS and cryogenic transmission electron microscopy (cryo-TEM). Direct imaging of the polymeric micelles in solution by cryo-TEM revealed different morphologies depending on the block sequence and the preparation conditions. While polymers with the sequence hydrophilic-lipophilic-fluorophilic built core-shell-corona micelles with the core being the fluorinated compartment, block copolymers with the hydrophilic block in the middle formed spherical micelles where single or multiple fluorinated domains “float” as disks on the surface of the lipophilic core. Increasing the temperature during micelle preparation or annealing of the aqueous solutions after preparation at higher temperatures induced occasionally a change of the micelle morphology or the particle size distribution. By RAFT polymerization not only the desired polymeric architectures could be realized, but the technique provided in addition a precious tool for molar mass characterization. The thiocarbonylthio moieties, which are present at the chain ends of polymers prepared by RAFT, absorb light in the UV and visible range and were employed for end-group analysis by UV-vis spectroscopy. A variety of dithiobenzoate and trithiocarbonate RAFT agents with differently substituted initiating R groups were synthesized. The investigation of their absorption characteristics showed that the intensity of the absorptions depends sensitively on the substitution pattern next to the thiocarbonylthio moiety and on the solvent polarity. According to these results, the conditions for a reliable and convenient end-group analysis by UV-vis spectroscopy were optimized. As end-group analysis by UV-vis spectroscopy is insensitive to the potential association of polymers in solution, it was advantageously exploited for the molar mass characterization of the prepared amphiphilic block copolymers. / Die Arbeit widmet sich der Synthese von neuen amphiphilen ternären "ABC" Block-Copolymeren und der Untersuchung ihrer Selbstorganisation zu mizellaren Überstrukturen in wässriger Lösung. Die Block-Copolymere wurden durch kontrollierte radikalische Polymerisation mittels des sogenannten „RAFT“ Prozesses (radical addition fragmentation chain transfer) hergestellt. Neben der Realisierung der gewünschten Polymerarchitekturen erlaubte es die Methode, die Molmassen der Polymere durch Endgruppenanalyse zu bestimmen. Die Kettenenden der Polymere tragen infolge des Polymerisationsmechanismus’ definierte Funktionalitäten, welche UV- und sichtbares Licht absorbieren und somit durch UV-vis-Spektroskopie quantifizierbar sind. Das Absorptionsverhalten der Endgruppen wurde untersucht und die UV-vis-Endgruppenanalyse optimiert. Es zeigte sich, dass die Vorteile der Methode ihre generelle Anwendbarkeit und ihre Unempfindlichkeit gegenüber der Assoziation von Polymeren in Lösung sind. Aufgrund ihrer drei unterschiedlichen Blöcke bilden die synthetisierten ABC Triblockcopolymere komplexere selbstorganisierte Strukturen als die bisher üblichen Diblockcopolymere. Die Triebkraft für ihre Selbstorganisation in wässriger Lösung ist im wesentlichen der hydrophobe Effekt. Es wurden zwei unterschiedliche Ansätze verfolgt: Zum einen wurden doppelt-schaltbare Triblockcopolymere hergestellt, von denen ein Block permanent wasserlöslich ist, während die anderen Blöcke jeweils eine untere Entmischungstemperatur in wässriger Lösung aufweisen. Diese Blöcke „schalten“ beim Erwärmen von hydrophil auf hydrophob. Oberhalb des ersten Phasenübergangs - bei der niedrigeren Entmischungstemperatur - assoziieren die Makromoleküle und bilden Polymermizellen im Nanometerbereich. Beim weiteren Erwärmen „schaltet“ auch der zweite Block und modifiziert den selbstorganisierten Zustand, während der permanent wasserlösliche Block für die Stabilisierung der Aggregate sorgt. Die Assoziation der Block-Copolymere ist nach Abkühlen der wässrigen Lösung vollständig reversibel. Die stufenweise Selbstorganisation wurde mit Hilfe von Turbidimetrie, Dynamischer Lichtstreuung (DLS) und 1H-NMR-Spektroskopie untersucht, da diese Methoden das Verhalten auf der makroskopischen, mesoskopischen und molekularen Skala widerspiegeln. Obwohl der einsetzende Selbstorganisationsprozess problemlos zu detektieren war, konnten die Veränderungen infolge des zweiten Phasenübergang nicht immer eindeutig identifiziert werden, da sie zum Teil mit der langsamen Reaktion des Systems auf relativ schnelle Temperaturänderungen zusammenfielen. Außerdem hängt die Aggregatbildung nicht nur sensibel von der detaillierten Polymerarchitektur ab, sondern unterliegt auch teilweise einer kinetischen Kontrolle. Der zweite Ansatz zu komplexeren Polymermizellen basierte auf der Inkompatibilität „triphiler“ Blockcopolymere als Triebkraft für die Selbstorganisation. Das heißt, die Block-Copolymere bestehen aus einem hydrophilen, einen lipophilen und einen fluorophilen (Fluorkohlenwasserstoff-liebenden) Teil, die jeweils miteinander unverträglich sind. Die Polymere assoziierten in Wasser zu Polymermizellen mit einer hydrophilen Korona und einem unterstrukturierten Mizellkern mit separaten Kohlenwasserstoff- und Fluorkohlenwasserstoff-Domänen – sogenannten Multi-Kompartiment-Mizellen. Die Assoziation der Triblock-Copolymere wurde mit 1H-NMR-Spektroskopie, DLS und cryogener Transmissionselektronenmikroskopie (cryo-TEM) untersucht. Die unmittelbare Abbildung der Polymermizellen in Lösung mittels cryo-TEM enthüllte unterschiedliche Morphologien in Abhängigkeit von der Blocksequenz und den Präparationsbedingungen. Während Polymere mit der Blocksequenz hydrophil-lipophil-fluorophil Kern-Schale-Korona-Mizellen mit der Fluor-Domäne als Kern bildeten, wurde eine neue, unerwartete Mizellmorphologie für die Polymere mit dem hydrophilen Block in der Mitte gefunden: Einzelne oder mehrere Fluordomänen “schwimmen” als Scheiben auf dem lipophilen Kern. Die beobachteten Morphologien sind weitgehend stabil, unterliegen aber ebenfalls - zumindest teilweise - einer kinetischen Kontrolle. So führten erhöhte Temperaturen während der Mizellpräparation gelegentlich zu einer Veränderung der Mizellmorphologie oder Partikelgröße.

ABC type amphiphilic triblock copolymers, polyethylene-b-poly(ethylene oxide)-b-poly (£`-caprolactone) (PE-b-PEO-b-PCL), were synthesized through ring-opening polymerization. We have successfully synthesized hierarchical mesoporous silicas using a simple evaporation-induced self-assembly (EISA) strategy. Two blocks of hydrophobic segment (PE and PCL) in the triblock copolymer (PE-b-PEO-b-PCL) involved in two-type mesepores after calcinations. We recognized the PE segment attributed to face centered cubic (f. c. c.) morphology (spherical pore) and the PCL segment attributed to tetragonal cylinder structure (cylinder pore) by small angle X-ray scattering (SAXS), transmission electron microscopy (TEM) and specific surface area & pore size distribution analyzer (BET), respectively. We also investigated the effect on pore size and morphology with changing the molecular weight of PCL and the ratios of TEOS/template/HCl. We also synthesized the mesoporous phenolic resin by triblock copolymer poly(ethylene oxide)-b-poly(£`-caprolactone)-b-poly(L-lactide) (PEO-b-PCL-b-PLLA). After curing and calcinations, we also explored the morphology and pore size distribution of mesoporous phenolic by SAXS, TEM, BET. Because of the sequence of hydrophobic segment PCL and PLLA lay in the same side, so we could only observe hexagonal cylinder structure and one pore size.

Nuclear power waste contains radioactive isotopes with long half lives and the problem lies in the fact that the lanthanides and actinides must be separated before the nuclear waste can be reprocessed. Transuranic Extraction (TRUEX), a liquid-liquid extraction method, has been developed but fails to separate the lanthanide and actinides and creates large volumes of liquid waste. It has been shown that attaching three CMPO (carbamoyl phosphine oxide) ligands used in the TRUEX process to a calixarene increases the separation and extraction efficiency of the system. The research goal is to attach the CMPO ligand to a polymer to make a membrane to be used in nuclear waste remediation. The triblock polymer system has been designed to have a cross-linking group to create the membrane structure, a solubilizing group to improve the flow of aqueous media through the membrane, and the CMPO ligand to chelate actinides. This paper describes the design of the polymer, its synthesis, and my research data. / text

Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico / O trabalho desenvolvido nesta dissertaÃÃo consiste no estudo do processo de funcionalizaÃÃo nÃo covalente de nanotubos de carbono com copolÃmeros tribloco e dibloco e a funcionalizaÃÃo covalente de nanotubos de carbono com Ãcido esteÃrico. A funcionalizaÃÃo nÃo covalente dos nanotubos de carbono foi realizada utilizando copolÃmeros tribloco e dibloco [tribloco E69S15E69, E69S7E69 (E = Ãxido de etileno, S = Ãxido de estireno), E65G7E65(E = Ãxido de etileno, G = Ãxido de fenilglicidil), o copolÃmero dibloco E20CL10 (E = Ãxido de etileno, CL = Ɛ-caprolactona)]. A individualizaÃÃo dos nanotubos de carbono com os copolÃmeros (em soluÃÃo) foi realizada usando a tÃcnica de agitaÃÃo, sonicaÃÃo e centrifugaÃÃo. As amostras obtidas foram caracterizadas por espectroscopia Raman ressonante excitando com laser de comprimento de onda de 532 nm (2,33 eV), e por fotoluminescÃncia no intervalo de 800 â 1700 nm. As caracterizaÃÃes foram realizadas de forma a identificar os tipos de nanotubos semicondutores, por fotoluminescÃncia, assim como tambÃm os demais por espectroscopia Raman. As caracterÃsticas espectrais comprovam a individualizaÃÃo dos nanotubos de carbono utilizando os copolÃmeros como meio dispersivo. A funcionalizaÃÃo covalente dos nanotubos de carbono foi realizada empregando Ãcido esteÃrico, e desenvolvida em 3 etapas: i) carboxilaÃÃo dos nanotubos de carbono utilizando a mistura H2SO4:HNO3; ii) funcionalizaÃÃo dos nanotubos com grupos COCl e iii) funcionalizaÃÃo dos nanotubos de carbono com Ãcido esteÃrico. A caracterizaÃÃo da amostra obtida foi realizada usando espectroscopia Raman ressonante, com excitaÃÃo no comprimento de onda de 514,5 nm (2,41 eV), FTIR, DSC em atmosfera de N2 e taxa de aquecimento de 10 ÂC/min no intervalo de 25 a 400 ÂC, e TGA em atmosfera de N2 e taxa de aquecimento de 10ÂC/min no intervalo de 25 a 900 ÂC. Estas caracterizaÃÃes foram realizadas de modo a obter elementos que indiquem a funcionalizaÃÃo covalente dos nanotubos de carbono com o Ãcido esteÃrico. Essa funcionalizaÃÃo reflete mudanÃaas na estrutura cristalina dos nanotubos de carbono, observada na espectroscopia Raman ressonante e bandas correspondentes a ligaÃÃes -OOC-O-COO- tÃpica de anidrido nos espectros de FTIR, assim como mudanÃas no comportamento tÃrmico dos nanotubos funcionalizados em relaÃÃo aos nanotubos de carbono puro. / The work developed in this thesis consists in the study of the process of non covalent functionalization of carbon nanotubes with triblock and diblock copolymers and covalent functionalization of carbon nanotubes with stearic acid. The non covalent functionalization of carbon nanotubes were realized using triblock copolymer [triblock E69S15E69, E69S7E69 (E= ethylene oxide, S = styrene oxide), E65G7E65 (E = ethylene oxide, G = phenyl glycidyl ether), the diblock copolymer E20CL10 (E = ethylene oxide, CL = Ɛ-caprolactone)] e SDS (sodium dodecyl sulfate). The individualization of carbon nanotubes with copolymer and SDS, were performed by stirring, sonication and centrifugation. The resulting samples were characterized using the Raman resonant spectroscopy study, exciting in wavelength of 532 nm (2.33 eV). The photoluminescence studies, in the copolymers and SDS solution, were realized using a detector InGaAs for detecting light in the intermission of 800 â 1700 nm, and a lamp of Xe, exciting in spectral intermission of 500 â 850 nm. The characterizations were used to identify the type of semiconductors carbon nanotubes, by photoluminescence, as well as the other identified by resonant Raman spectroscopy and the aspects that showing the individualization of carbon nanotubes using copolymers matrix. The covalent functionalization of carbon nanotubes were realized using stearic acid. The functionalization was performed in three steps, carboxylation of carbon nanotubes, usingfor this the mixture H2SO4:HNO3, functionalization of carbon nanotubes with COCl groups and functionalization of carbon nanotubes with stearic acid. The characterization of the obtained sample was realized using the Raman resonant spectroscopy study, exciting with laser at wavelength of 514,5 nm (2,41 eV), FTIR, DSC, in N2 atmosphere and heating rate of 10ÂC/min in the intermission of 25 â 400 ÂC, and TGA, in N2 atmosphere and heating rate of 10 ÂC/min with intermission 25 â 900 ÂC. These characterizations were realized in order to confirm the covalent functionalization of the carbon nanotubes with stearic acid, obtaining shift in the crystalline structure of the carbon nanotubes, showed by the Raman resonant spectroscopy study and corresponding -OOC-O-COO- anhydride bond also showed in the FTIR spectroscopy, as well as change in the thermal behavior of the carbon nanotubes functionalized in comparison with pure carbon nanotubes.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / O objetivo deste trabalho foi investigar misturas de sistemas de copolÃmeros triblocos do tipo E62P39E62 (comercialmente chamado de F87) e E137S18E137 (sintetizado por polimerizaÃÃo aniÃnica e denominado de S18) como novos veÃculos para solubilizaÃÃo e liberaÃÃo controlada de fÃrmacos. As caracterÃsticas desejÃveis de gelatinizaÃÃo das soluÃÃes do copolÃmero E62P39E62 combinadas com as capacidades de solubilizaÃÃo das soluÃÃes do copolÃmero E137S18E137 foram estudadas utilizando o mÃtodo de inversÃo de tubo e por reologia oscilatÃria. A estrutura dos gÃis foi obtida por espalhamento de raios-X a baixos Ãngulos (SAXS) e por microscopia de luz polarizada (PLM). O raio hidrodinÃmico (rh) das micelas foi obtido por espalhamento de luz dinÃmico (DLS), e a capacidade de solubilizaÃÃo (scp) dos copolÃmeros separados e para as misturas dos dois na faixa 50/50 a 90/10 %m/m de E62P39E62/E137S18E137, foi avaliada por espectroscopia de ultravioleta-visÃvel (UV-Vis). Os limites gel/fluido dos copolÃmeros isolados e suas misturas foram determinados pelo mÃtodo de inversÃo de tubo e confirmado por reometria. Os resultados de SAXS e PLM para a mistura 1 (50/50 % m/m E137S18E137/E62P39E62 e para E137S18E137 e E62P39E62 isolados), indicaram estrutura cÃbica de corpo centrado (ccc), conforme indicado por reologia. DLS indicou a formaÃÃo de micelas determinadas pelo copolÃmero E62P39E62. A scp dos copolÃmeros e misturas revelou resultados promissores para aplicaÃÃo de misturas binÃrias de copolÃmeros como sistemas de liberaÃÃo de fÃrmacos envolvendo gelatinizaÃÃo in situ. / The aim of this work was to investigate mixed systems of triblock copolymer type E62P39E62 (commercially denoted F87) and E137S18E137 (prepared by oxyanionic polymerization) as novel vehicles for solubilisation and controlled delivery of aromatics drugs The desirable gelation characteristics of solutions of the EmPnEm copolymers with the greater solubilising capacities of solutions of the EmSnEm were investigatedo using an inverted tube test method and by oscillatory rheometry. The structure of the gels was obtained by small angle X-ray scattering (SAXS) and polarized-light microscopy (PLM).The hydrodynamic radius (rh) of the micelle was obtained by dynamic light scattering (DLS). The solubilisation capacity (scp) for the separate copolymers and for mixtures of the two in the range 50/50 to 90/10 wt % E137S18E137/E62P39E62was evaluated by UV-Vis. The fluid/gel boundaries for the copolymers alone and its mixtures were determined by the tube inversion method and confirmed by rheometry. SAXS and PLM for mixture 1 (50/50 wt % E137S18E137/E62P39E62 and for E137S18E137 and E62P39E62 alone) all have shown similar body-centred cubic (bcc) structures with similar lattice dimensions as confirmed by rheology. DLS indicated micelle formation determined by E62P39E62 copolymer. The scp measured for the separate copolymers and its mixtures revealed promise results for application of binary mixtures of copolymer as systems for drug release involving in situ gelation.

The presented thesis on thermosensitive polymer gel is focused especially on a thermosensitive triblock copolymer, which is composed of hydrophobic polylactide, polyglycolid and hydrophilic polyethylene glycol (PLGA-PEG-PLGA). Thermosensitive copolymers are very attractive for their phase sol-gel transitions and gel-suspension transitions. The aqueous solution of this copolymer behaves like a sol at laboratory temperature and like a gel at body temperature. These systems are used as injectable carriers for targeted drug delivery with controlled release. However, the influence of the resulting polymer concentration and temperature on the thermosensitive hydrogel nanostructure was not yet fully studied. In the experimental part, the viscoelastic behavior of hydrogels was observed by dynamic rheological analysis at different polymer concentrations and temperature conditions. The average size and distribution of micelles of triblock copolymer in aqueous solution were measured using dynamic light scattering technique. Characterization of fibrous micelles was complemented by imaging technique, cryogenic transmission electron microscopy.

No description available.