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The Global ETD Search service is a free service for researchers
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Showing 1 to 3 of 3 (0.071 seconds)Spelling suggestions: "subject:"tricyclic compound"" "subject:"pericyclic compound""
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Pyrolytic study of para-methoxystyrylarenes, 2-azidocyclohexanone and 6-arylfulvenesChu, Li-Tse 22 July 2005 (has links)
1. FVP of para-methoxystyrylarenes (5a-c) all gave the corresponding phenol products 21a-c. FVP of 5a and 5c also gave tricyclic products 22 and 23, respectively, which all included indene structure. But FVP of 5b gave naphthalene by ring opening of the furan.
2. FVP of 2-azidocyclohexanone (70) gave four products 83-86, and product 84 was a new compound. We provided a method to synthesize a new tricyclic product by one step.
3. Pyrolytic study of five 6-arylfulvenes (78-82). The products from FVP of 78-82 and mechanisms to account for their products will be discussed. FVP of compounds 79 and 80 gave naphthalene (96) and indene (97), respectively, by elimination of either a S or a CO molecule.
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The Changes In Surface Energetics With Relative Humidity Of Carbamazepine And Paracetamol As Measured By Inverse Gas Chromatography.Sunkersett, Mohit R., Grimsey, Ian M., Doughty, Stephen W., Osburn, John C., York, Peter, Rowe, Raymond C. January 2001 (has links)
No / The surface energetic parameters of carbamazepine and paracetamol have been studied using inverse gas chromatography modified to produce dry and ambient conditions within the column. The values of the dispersive component of the surface free energy (¿DS) do not change significantly at the increased relative humidity. In contrast the specific component of the free energy of adsorption (-¿GSPA) as measured by polar probes, can either remain constant or decrease by up to 10%, depending on the material and the probe. This indicates that an increase in the relative humidity causes a decrease in the surface energetics of the powder surface. It is proposed that where the water molecules are adsorbing to the same sites as the polar probes, the interaction of these probes with the surface is decreased. To identify these sites, the preferential interaction of each probe, including water, with the drug molecule has been modelled.
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Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cellsTeesdale-Spittle, P.H., Pors, Klaus, Brown, R., Patterson, Laurence H., Plumb, J.A. January 2005 (has links)
No / A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkyl-amino side chains. One aminoanthraquinone (13) was further derivatized to a chloropropyl-amino analogue by treatment with triphenylphosphine-carbon tetrachloride. The compounds were evaluated in the A2780 ovarian cancer cell line and its cisplatin-resistant variants (A2780/ cp70 and A2780/MCP1). The novel anthraquinones were shown to possess up to 5-fold increased potency against the cisplatin-resistant cells compared to the wild-type cells. Growth curve analysis of the hydroxyethylaminoanthraquinone 8 in the osteosarcoma cell line U-2 OS showed that the cell cycle is not frozen, rather there is a late cell cycle arrest consistent with the action of a DNA-damaging topoisomerase II inhibitor. Accumulative apoptotic events, using time lapse photography, indicate that 8 is capable of fully engaging cell cycle arrest pathways in G2 in the absence of early apoptotic commitment. 8 and its chloropropyl analogue 13 retained significant activity against human A2780/cp70 xenografted tumors in mice.
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