Global ETD Search

1	Component-Based Syntheses of Trioxacarcins Smaltz, Daniel Jonathan 06 June 2014 (has links) The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex DNA. This dissertation presents a component-based synthetic route to the trioxacarcin structural class, broadly defined, which resulted in fully synthetic routes to trioxacarcin A (1), DC-45-A1 (10), and a diverse collection of analogs. / Chemistry and Chemical Biology Organic chemistry analog antiproliferative DC-45-A1 glycosylation synthesis trioxacarcin
2	Crystallographic studies on DNA in complex with antibiotics and effects of anisotropic scaling on structure solution / Kristallstrukturanalyse von DNA in Komplexen mit Antibiotika und Effekte anisotroper Skalierung auf die Strukturlösung Pfoh, Roland 30 October 2008 (has links) No description available. 500 Naturwissenschaften allgemein Mathematics and Computer Science Trioxacarcin A Echinomycin Anisotrope Skalierung trioxacarcin A echinomycin DNA-drug complex anisotropic scaling DNA hexaplex 35.25 35.65