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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.021 seconds)

Spelling suggestions: "subject:"trioxacarcin A"" "subject:"trioxacarcine A""

1

Component-Based Syntheses of Trioxacarcins

Smaltz, Daniel Jonathan 06 June 2014 (has links)
The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex DNA. This dissertation presents a component-based synthetic route to the trioxacarcin structural class, broadly defined, which resulted in fully synthetic routes to trioxacarcin A (1), DC-45-A1 (10), and a diverse collection of analogs. / Chemistry and Chemical Biology
Organic chemistry
analog
antiproliferative
DC-45-A1
glycosylation
synthesis
trioxacarcin
2

Crystallographic studies on DNA in complex with antibiotics and effects of anisotropic scaling on structure solution / Kristallstrukturanalyse von DNA in Komplexen mit Antibiotika und Effekte anisotroper Skalierung auf die Strukturlösung

Pfoh, Roland 30 October 2008 (has links)
No description available.
500 Naturwissenschaften allgemein
Mathematics and Computer Science
Trioxacarcin A
Echinomycin
Anisotrope Skalierung
trioxacarcin A
echinomycin
DNA-drug complex
anisotropic scaling
DNA hexaplex
35.25
35.65

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