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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Caracterização morfológica, biológica e molecular de três cepas de Trypanosoma cruzi Chagas, 1909 (Kinetoplastida, Trypanosomatidae) isoladas de exemplares de Triatoma sordida (Stall) 1859 (Hemiptera, Reduviidae) / Morphological, biological and molecular characterization of three Trypanosoma cruzi Chagas, 1909 (Kinetoplastida, Trypanosomatidae) stains isolated of Triatoma sordida Stal 1859 (Hemiptera, Reduviidae) specimens

Ribeiro, Aline Rimoldi, 1980- 08 March 2010 (has links)
Orientador: João Aristeu da Rosa / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-08-16T17:55:39Z (GMT). No. of bitstreams: 1 Ribeiro_AlineRimoldi_M.pdf: 8854165 bytes, checksum: dfc09fd67f41d32a061c2b77ca9455b8 (MD5) Previous issue date: 2010 / Resumo : A doenca de Chagas, assim como seu agente etiologico Trypanosoma cruzi, foram descritos por Carlos Ribeiro Justiniano das Chagas. T. cruzi e transmitido por hemipteros sendo os generos Panstrongylus, Rhodnius e Triatoma os mais importantes. Com resultados bastante satisfatorios em relacao ao controle do principal vetor, T. infestans, outros triatomineos de importancia secundaria, coletados no peridomicilio, passaram a assumir maior relevancia, dentre essas especies, T. sordida. As populacoes de T. cruzi apresentam grande variabilidade intraespecifica evidenciada por diferencas na morfologia, na virulencia e patogenicidade, na habilidade de evasao a resposta imune do hospedeiro e na constituicao antigenica. Essa diversidade pode estar associada a sua adaptacao e sobrevivencia em diferentes hospedeiros. As diferentes formas de manifestacao clinica da doenca no homem podem ser associadas com cepas especificas ou com marcadores geneticos do hospedeiro, embora ambos possam influenciar o curso da infeccao. Este trabalho objetivou a caracterizacao biologica, morfologica e molecular de tres cepas de T. cruzi (SI5, SI8 e SIGR3) isoladas de T. sordida coletadas em Santo Inacio, Bahia. Desse modo, o estudo biologico indicou que as cepas isoladas de Santo Inacio, pertencem ao Biodema III e Zimodema I. Os resultados das mensuracoes das cepas SI5, SI8 e SIGR3 mostraram polimorfismo das formas tripomastigotas sanguineas, embora com predominancia de formas intermediarias para largura do corpo e curtas para comprimento total do corpo no decurso da infeccao experimental. Foram avaliados para as formas epimastigotas, parametros como comprimento total do corpo, largura e indice nuclear e observamos para as cepas SI5, SI8 e SIGR3 respectivamente, formas intermediaria/intermediaria/baixo, curto/intermediario/baixo e curta/larga/baixo para os parametros descritos acima. O significado geral desse polimorfismo ainda nao foi suficientemente investigado, desconhecendo-se se ele expressa um diferente comportamento biologico das cepas ou se reflete apenas a existencia de um "complexo" morfologico. A caracterizacao molecular das cepas SI5, SI8 e SIGR3, as enquadram no grupo II, o que indica, que nesse local circula uma mesma linhagem de T. cruzi, apesar das mesmas terem sido isoladas de hospedeiros e epocas distintas. / Abstract: Chagas disease and its causative agent Trypanosoma cruzi were described by Carlos Ribeiro Justiniano das Chagas. T. cruzi is transmitted by blood-sucking hemipterous and Panstrongylus, Rhodnius and Triatoma are the most important genera. Satisfactory results were achieved to the control of the main vector, T. infestans. However, other bugs of secondary importance, like Triatoma sordida collected around the houses began to assume greater epidemiological importance. The populations of T. cruzi show great variability among individuals demonstrated by differences in morphology, virulence and pathogenicity, ability to evade the host immune response and antigenic constitution. Such diversity may be associated with their adaptation and survival in different hosts. The course of the infection in human may be associated with specific strains or host genetic markers, although both can influence. This aim of this study was the biological, morphological and molecular characterization of three strains of T. cruzi (SI5, and SI8 SIGR3) isolated from T. sordida collected in Santo Inacio, Bahia. The biological study indicated that the isolates from Santo Inacio, belong to Biodeme III Zimodeme I. The results of measurements of the strains SI5, SI8 SIGR3 showed polymorphism of blood trypomastigotes, with a predominance of intermediate forms to body width and short length for total body in the course of experimental infection. Parameters such as: total body length, width and nuclear index were evaluated for epimastigotes, and observed for strains SI5, SI8 and SIGR3 respectively, forms na intermediate / middle / low, short / intermediate / low, short / wide / low for the parameters described above. The general meaning of this polymorphism has not been sufficiently investigated. It is not known if such poliymorphism expresses a different biologic behavior of the strains or merely is a result of a "complex" morphology. According to the molecular characterization the strains SI5, SI8 SIGR3 are in group II, which indicates that in this site it occurs the same lineage of T. cruzi, despite their different sources (isolated from different hosts and different times). / Mestrado / Parasitologia / Mestre em Parasitologia

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