Levels of soybean trypsin inhibitors (SBTI) in soy-based infant formulas were measured and found to range from 3 to 28% of the activity measured in raw soybeans, with higher activity usually present in ready-to-feed compared to concentrate or powder formulations. Experiments were conducted to examine the influence of dietary SBTI on growth, serum enzyme, lipid and free amino acids and hepatic S-adenosylmethionine (SAM) status in weanling male rats. Diets containing graded amounts of SBTI were fed with and without the methionine antagonist ethionine. Changes in growth, serum enzymes, lipid and amino acid parameters in rats fed SBTI or ethionine indicated lipotrope deficit and compromise of the transsulfuration pathway. The combination of SBTI and ethionine exacerbated many of the symptoms and methyl donor deficit was indicated by hepatic SAM status. Methionine supplementation of SBTI + ethionine diets was beneficial at moderating changes while cysteine supplementation was not.

Thesis (Ph. D.)--Columbia University, 1923. / Vita. Bibliography: p. 24.

Thesis (M.S.)--Florida State University, 2004. / Advisors: Dr. Wei-Chun Chin and Dr. George Bates, Florida State University, College of Arts and Sciences, Dept. of Biological Science. Title and description from dissertation home page (viewed Sept. 23, 2004). Includes bibliographical references.

Bielefeld, Universiẗat, Diss., 2000.

It has been shown previously in our laboratory that zebrafish produce trypsin from their gills when they are under stress, and this trypsin is involved in thrombocyte activation via PAR2 during gill bleeding. In this study, I investigated another role of the trypsin that is secreted from zebrafish. This investigation has demonstrated a novel role of trypsin in zebrafish. Not only did this investigation demonstrate the role of trypsin in zebrafish behavior, but also it showed that PAR2 might be the receptor that is involved in trypsin-mediated behavioral response. In addition, we have shown that Gq and ERK inhibitors are able to block the trypsin pathway and prevent the escaping behavior. Finally, the results of this investigation suggest that the cells that respond to trypsin are surface cells, which have an appearance similar to that of neuromast cells.

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