In this study, I show that three major areas of Mark Twain's personality—conscience, ego, and nonconformist instincts—are represented, in part, respectively by three of his literary creations: Huckleberry Finn, Tom Sawyer, and No. 44. The origins of Twain's personality which possibly gave rise to his troubled conscience, need for attention, and rebellious spirit are examined. Also, Huck as Twain's social and personal conscience is explored, and similarities between Twain's and Tom's complex egos are demonstrated. No. 44 is featured as symbolic of Twain's iconoclastic, misanthropic, and solipsistic instincts, and the influence of Twain's later personal misfortunes on his creation of No. 44 is explored. In conclusion, I demonstrate the importance of Twain's creative escape and mediating ego in the coping of his personality with reality.