Prostate cancer is one of the most common malignant tumors in solid organs of old men. Prostate-specific antigen (PSA) is a valuable prostate cancer biomarker that is now wildly used for population screening, diagnosis, and monitoring of patients with prostate cancer. Howere it is reported that PSA is not feasible to discriminate the progress of prostate cancer, so many investigators still works on developing new biomarker of prostate carcinoma. Here, we propose the study of differentially expressed prostate proteins in blood of patients. With the aid of two-dimensional polyacrylamide gel electrophoresis (2-DE) and matrix-assisted laser desorption-induced time of flight (MALDI-TOF) mass spectrometry, comparison of normal men and prostate cancer patients serum proteins and analysis protein variation of different stages of prostate cancer serum. We find 31 and 17 protein spots overexpression in cancer development and after treatment, respectively. At present, with the aid of SWISS-PORT database and MALDI-TOF mass spectrometry, we had identified fibrinogen gamma chain, fibrinogen alpha/alpha-E chain, major histocompatibility complex (MHC), class I, C and Mayven were overexpressed in prostate cancer development, where Mayven is fist reported by us.

Push-pull charge-transfer organic molecules exhibit large second-order nonlinear optical nonlinearity , and have been used to manufacture efficient photonic devices .We study a series of CT molecules by using the two-photon scattering method with a tunable femto-second pulsed-laser to obtain the value of the molecular first hyperpolarizability (£]) .We discuss the relationship between the£]value and chemical structure , and compare the£]values with the two-level model prediction for several incident laser excitation wavelength.

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Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009. / Committee Chair: Brédas, Jean-Luc; Committee Member: Janata, Jiri; Committee Member: Kippelen, Bernard; Committee Member: Marder, Seth; Committee Member: Sherrill, David. Part of the SMARTech Electronic Thesis and Dissertation Collection.

Thesis (Ph. D.)--Lehigh University, 2001. / Includes vita. Includes bibliographical references (leaves 224-230).

Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 143-146).

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