The University Course Timetabling Problem (UCTP) is the problem of assigning locations (lecture halls, computer rooms) and time slots (time and date) to a set of events (lectures, labs) while satisfying a number of constraints such as avoiding double-bookings. Many variants of problem formulations exist, and most realistic variants are thought to be NP-hard. A recent trend in solving hard scheduling problems lies in the application of hybrid metaheuristics, where improvements are often found by hybridizing a population-based approach with some form of local search. In this paper, an implementation of a Genetic Algorithm (GA) that solves the UCTP is hybridized with local search in the form of Tabu Search (TS). The results show significant improvements to the performance and scalability over the non-hybridized GA. Two application strategies for the TS are investigated. The first strategy performs a switch-over from the GA to the TS, while the second interleaves the two algorithms. The effectiveness of each application strategy is seen to depend on the characteristics of the individual algorithms. / Schemaläggningsproblemet UCTP (University Course Timetabling Problem) består av problemet att tilldela platser (föreläsningssalar, laborationssalar) och tidpunkter (datum och klockslag) till en mängd tillställningar (föreläsningar, laborationer) under kravet att upprätthålla en mängd restriktioner, exempelvis att undvika dubbelbokningar. Det finns många varianter av problemformuleringen och de flesta realistiska formuleringer anses ge upphov till NP-svåra optimeringsproblem. En förhållandevis ny trend för lösningsmodeller till svåra schemaläggningsproblem ligger i tillämpningen av hybrida metaheuristiker, där förbättringar ofta ses när populationsbaserade algoritmer kombineras med någon typ av lokalsökning. I denna rapport undersöks en UCTP-lösning baserad på en Genetisk Algoritm (GA) som hybridiseratsmed en lokalsökning i form av en Tabusökning (TS). Resultaten visar på signifikanta förbättringar i prestanda och skalbarhet jämfört med den icke-hybridiserade GA:n. Två appliceringsstrategier för TS undersöks. Den första strategin utgörs av att byta algoritm från GA till TS, medan den andra utgörs av att sammanfläta de två algoritmerna. Appliceringsstrategiernas effektivitet ses bero av de individuella algoritmernas egenskaper.

In this dissertation, we address three different combinatorial optimization problems (COPs), each of which has specific real-life applications. Owning to their specific nature, these problems are different from those discussed in the literature. For each of these problems, we present a mathematical programming formulation, analyze the problem to determine its useful, inherent structural properties, and develop an efficient methodology for its solution by exploiting these properties. The first problem that we address is the course timetabling problem encountered at Virginia Tech. The course timetabling problem for a university is a difficult problem and has been studied by many researchers over the years. As a result, a plethora of models and approaches have been reported in the literature. However, most of these studies have focused on applications pertaining to course scheduling for a single or at most few departments of a university. The sheer size of the university-wide timetabling problem that we address, involving thousands of courses to be scheduled in hundreds of classrooms in each semester, makes it a challenging problem. We employ an appropriate decomposition technique that relies on some inherent structural properties of the problem both during the modeling and algorithmic development phases. We show the superiority of the schedules generated by our methodology over those that are currently being used. Also, our methodology requires only a reasonable amount of computational time in solving this large-size problem. A facility layout problem involving arbitrary-shaped departments is the second problem that we investigate in this dissertation. We designate this problem as the arbitrary-shaped facility layout problem (ASFLP). The ASFLP deals with arranging a given set of departments (facilities, workstations, machines) within the confines of a given floor space, in order to optimize a desired metric, which invariably relates to the material handling cost. The topic of facility planning has been addressed rather extensively in the literature. However, a major limitation of most of the work reported in the literature is that they assume the shape of a department to be a rectangle (or even a square). The approach that relies on approximating an arbitrary-shaped department by a rectangle might result in an unattractive solution. The key research questions for the ASFLP are: (1) how to accurately model the arbitrary-shaped departments, and (2) how to effectively and efficiently determine the desired layout. We present a mixed-integer programming model that maintains the arbitrary shapes of the departments. We use a meta-heuristic to solve the large-size instances of the ASFLP in a reasonable amount of time. The third problem that we investigate is a supply chain scheduling problem. This problem involves two stages of a supply chain, specifically, a manufacturer and one or more customers. The key issue is to achieve an appropriate coordination between the production and distribution functions of the manufacturer so as to minimize the sum of the shipping and job tardiness costs. We, first, address a single customer problem, and then, extend our analysis to the case of multiple customers. For the single-customer problem, we present a polynomial-time algorithm to solve it to optimality. For the multiple-customer problem, we prove that this problem is NP-hard and solve it by appropriately decomposing it into subproblems, one of which is solvable in polynomial time. We propose a branch-and-bound-based methodology for this problem that exploits its structural properties. Results of an extensive computational experimentation are presented that show the following: (1) our algorithms are efficient to use and effective to implement; and (2) significant benefits accrue as a result of integrating the production and distribution functions. / Ph. D.