Στόχος της παρούσας εργασίας είναι η ακινητοποίηση λιποσωμάτων με εγκλωβισμένη Tobramycin σε επιχρυσωμένες μεταλλικές επιφάνειες, με σκοπό την παρασκευή αντιμικροβιακών ενδοπροθέσεων του ουροποιητικού, που αποδεσμεύουν φάρμακο με ελεγχόμενο ρυθμό. / The aim of this study is to covalently link liposomes on metallic surfaces, as a method to prepare antimicrobial controlled (release) drug-eluting stents, using Tobramycin (TOB) as an anti-microbial drug. As a preliminary step for immobilization of TOB, different types of liposomes were constructed and evaluated for TOB loading efficiency, size distribution and ζ-potential. TOB concentrations were measured by a chemiluminescence immunoassay (ADVIA Centaur, Siemens), after modulating the technique as required for the specific samples. Results show that extruded DRV liposomes with similar sizes (mean diameter) with that of SUV liposomes (~95 nm), have 4 times higher drug loading efficiency.