O agente mutagênico N-ethyl-N-nitrosourea (ENU) é amplamente utilizado para produzir novas mutações em camundongos, dando origem aos mutantes recessivos equilíbrio (eqlb), que possui uma mutação pontual no gene NADPH oxidase 3 (Nox3), cromossomo 17 e mergulhador (mlh), no gene Otopetrin 1 (Otop1), cromossomo 5; sendo que ambos apresentam alterações vestibulares. Devido à semelhança da função do aparelho vestibular humano e do camundongo, a análise comportamental desses modelos pode ser uma valiosa contribuição para identificar alterações no controle do equilíbrio e do movimento. Deste modo, com o objetivo caracterizar o comportamento dos mutantes eqlb e mlh foram realizados os seguintes testes: avaliação da atividade geral por observação direta no campo aberto, coordenação motora na trave elevada, labirinto em cruz elevada (LCE), para avaliar o comportamento do tipo ansioso, labirinto em T e reconhecimento de objetos para avaliar a memória, além do teste de suspensão pela cauda para verificar o comportamento do tipo depressivo. Os resultados mostraram que em comparação aos camundongos BALB/c, os mutantes eqlb e mlh apresentaram redução do reflexo auricular, reflexo de endireitamento, resposta ao toque, na locomoção e na frequência de levantar. A redução do reflexo auricular, da resposta ao toque e do redução do reflexo de endireitamento mostrou um possível prejuízo do sistema psicomotor. A redução da frequência de levantar provavelmente foi consequência da dificuldade motora dos camundongos mutantes. Os resultados do teste da trave elevada indicaram que os mutantes eqlb e mlh apresentaram um prejuízo motor principalmente relacionado à coordenação motora. O tempo de imobilidade aumentado no teste de suspensão pela cauda e a incapacidade de nadar em camundongos eqlb e mlh reforçaram o papel do sistema vestibular na manutenção da percepção de gravidade, movimento e equilíbrio. / The mutagenic agent N-ethyl-N-nitrosourea (ENU) is widely used to produce new mutations in mice, giving origin to the equilíbrio (eqlb) which has a mutation in the NADPH oxidase 3 (Nox3) gene, chromosome 17 and mergulhador (mlh) in the gene Otopetrin 1 (Otop1), chromosome 5; both mutant strain showed vestibular impairment. Due to the similarity of the vestibular apparatus between human and mouse, the behavioral analysis of the mutant can be a valuable contribution to identify alterations involved in the control of balance and movement. This study aimed to characterize the behavior of eqlb and mlh mutant mice using the following behavioral tests: evaluation of the general activity by direct observation in the open field, motor coordination in the balance beam, elevated plus maze to evaluate the behavior of the anxious type, T-maze and recognition of objects to evaluate memory. In addition, tail suspension test was used to verify depressive like behavior. The results showed that in relation to the BALB/c mice, the mutants eqlb and mlh showed reduction of auricular reflex, surface-righting reflex, touch response, locomotion and rearing frequency. The reduction of the auricular reflex and the touch response pointed to the impairment of the psychomotor system, and the reduction of the surface-righting reflex showed a possible impairment of the psychomotor system. The reduction in the rearing frequency was, probably, a consequence of the motor impairment observed in the mutant strains. The results of the elevated plus maze test indicated that the mutants eqlb and mlh showed motor impairment mainly related to motor coordination. The increased immobility time in the tail suspension test and the inability to swim in eqlb and mlh mice reinforced the role of the vestibular system in maintaining the perception of gravity, movement, and balance.

O agente mutagênico N-ethyl-N-nitrosourea (ENU) é amplamente utilizado para produzir novas mutações em camundongos, dando origem aos mutantes recessivos equilíbrio (eqlb), que possui uma mutação pontual no gene NADPH oxidase 3 (Nox3), cromossomo 17 e mergulhador (mlh), no gene Otopetrin 1 (Otop1), cromossomo 5; sendo que ambos apresentam alterações vestibulares. Devido à semelhança da função do aparelho vestibular humano e do camundongo, a análise comportamental desses modelos pode ser uma valiosa contribuição para identificar alterações no controle do equilíbrio e do movimento. Deste modo, com o objetivo caracterizar o comportamento dos mutantes eqlb e mlh foram realizados os seguintes testes: avaliação da atividade geral por observação direta no campo aberto, coordenação motora na trave elevada, labirinto em cruz elevada (LCE), para avaliar o comportamento do tipo ansioso, labirinto em T e reconhecimento de objetos para avaliar a memória, além do teste de suspensão pela cauda para verificar o comportamento do tipo depressivo. Os resultados mostraram que em comparação aos camundongos BALB/c, os mutantes eqlb e mlh apresentaram redução do reflexo auricular, reflexo de endireitamento, resposta ao toque, na locomoção e na frequência de levantar. A redução do reflexo auricular, da resposta ao toque e do redução do reflexo de endireitamento mostrou um possível prejuízo do sistema psicomotor. A redução da frequência de levantar provavelmente foi consequência da dificuldade motora dos camundongos mutantes. Os resultados do teste da trave elevada indicaram que os mutantes eqlb e mlh apresentaram um prejuízo motor principalmente relacionado à coordenação motora. O tempo de imobilidade aumentado no teste de suspensão pela cauda e a incapacidade de nadar em camundongos eqlb e mlh reforçaram o papel do sistema vestibular na manutenção da percepção de gravidade, movimento e equilíbrio. / The mutagenic agent N-ethyl-N-nitrosourea (ENU) is widely used to produce new mutations in mice, giving origin to the equilíbrio (eqlb) which has a mutation in the NADPH oxidase 3 (Nox3) gene, chromosome 17 and mergulhador (mlh) in the gene Otopetrin 1 (Otop1), chromosome 5; both mutant strain showed vestibular impairment. Due to the similarity of the vestibular apparatus between human and mouse, the behavioral analysis of the mutant can be a valuable contribution to identify alterations involved in the control of balance and movement. This study aimed to characterize the behavior of eqlb and mlh mutant mice using the following behavioral tests: evaluation of the general activity by direct observation in the open field, motor coordination in the balance beam, elevated plus maze to evaluate the behavior of the anxious type, T-maze and recognition of objects to evaluate memory. In addition, tail suspension test was used to verify depressive like behavior. The results showed that in relation to the BALB/c mice, the mutants eqlb and mlh showed reduction of auricular reflex, surface-righting reflex, touch response, locomotion and rearing frequency. The reduction of the auricular reflex and the touch response pointed to the impairment of the psychomotor system, and the reduction of the surface-righting reflex showed a possible impairment of the psychomotor system. The reduction in the rearing frequency was, probably, a consequence of the motor impairment observed in the mutant strains. The results of the elevated plus maze test indicated that the mutants eqlb and mlh showed motor impairment mainly related to motor coordination. The increased immobility time in the tail suspension test and the inability to swim in eqlb and mlh mice reinforced the role of the vestibular system in maintaining the perception of gravity, movement, and balance.

No description available.

No description available.

Background: Vestibular dysfunction, characterized by nausea, dizziness, imbalance, and/or gait disturbance, represents an important sport-related concussion (SRC) subtype associated with prolonged recovery. Vestibular physical therapy promotes recovery; however, the benefit of earlier therapy is unclear. Hypothesis: Earlier vestibular therapy for young athletes with SRC is associated with earlier return to play (RTP), return to learn (RTL), and symptom resolution. Study Design: Retrospective cohort study. Level of Evidence: Level 3. Methods: Patients aged 5 to 23 years with SRC who initiated vestibular rehabilitation therapy (VRT) from January 2019 to December 2019 were included and patient records were reviewed. Therapy initiation was defined as either early, ≤30 days postinjury, or late (>30 days). Univariate comparisons between groups, Kaplan-Meier plots, and multivariate Cox proportional hazard modeling were performed. Results: Overall, 23 patients (10 early, 13 late) aged 16.14 ± 2.98 years and 43.5% were male patients. There was no difference between group demographics or medical history. Median initial total and vestibular symptom scores were comparable between groups. The late therapy group required additional time to RTP (110 days [61.3, 150.8] vs 31 days [22.5, 74.5], P = 0.03) and to achieve symptom resolution (121.5 days [71, 222.8] vs 54 days [27, 91], P = 0.02), but not to RTL (12 days [3.5, 26.5] vs 17.5 days [8, 20.75], P = 0.09). Adjusting for age and initial total symptom score, earlier therapy was protective against delayed symptom resolution (P = 0.01). Conclusion: This pilot study suggests that initiating VRT within the first 30 days after SRC is associated with earlier RTP and symptom resolution. Further prospective trials to evaluate if even earlier VRT should be pursued to further improve recovery time. Clinical Relevance: Clinicians should screen for vestibular dysfunction and consider modifying follow-up schedules after SRC to initiate VRT within a month of injury for improved outcomes.

No description available.

Made available in DSpace on 2016-04-27T18:47:31Z (GMT). No. of bitstreams: 1 Renata Porcel de Oliveira.pdf: 496419 bytes, checksum: b96ca2f7bdabe976ce0313c41eb0c649 (MD5) Previous issue date: 2008-10-07 / The research "Implications of vestibular dysfunction in the family and social coexistence of elderly" wide knowledge relevant to the interfaces between the areas of Social Gerontology and Health The central objective of this study is to examine the influences of the involvement of vestibular dysfunction by elderly people in their conviviality family and social relationships, seeking help in this segment can live fully the stage of old age and have a treatment with quality. The development of concepts concerning the anatomy and physiology of the vestibular system, as well as the understanding of possible malfunctions causing these diseases, particularly noted in the ageing process, are addressed recital is a broad concept of health. The search was conducted of field through the application of interviews involving nine elderly people aged over 65 years, which have the vestibular dysfunction, receive emergency medical care and carry out physiotherapy home with professionals in MEDMAR / FAMILY The Emergency Medical Service, located in the city of Santos, in the State of Sao Paulo. These elderly live with their families, which were also interviewed. Bringing up procedures methodological own qualitative research was done, initially, the characterization of the stage of vestibular dysfunction of the subject, based on existing medical diagnoses. Through semistructured guide, proceeded to the identification of the condition of personal life and family and social coexistence, before and after the onset of the disease. Data analysis shows that the vestibular dysfunction should be conceived as one of the constituent elements of the ageing process and that the symptoms of manifestation of this involvement must be properly understood and cares for the elderly by it and by their relatives, considering the impact recognized in depositions, both in family and social coexistence / A pesquisa "Repercussões da disfunção vestibular no convívio familiar e social de idosos" amplia conhecimentos pertinentes às interfaces entre as áreas da Gerontologia Social e da Saúde. O objetivo central deste estudo é analisar as influências do acometimento da disfunção vestibular por pessoas idosas, no seu convívio familiar e relacionamento social, visando contribuir para que esse segmento possa viver plenamente a fase da velhice e dispor de um tratamento com qualidade. O desenvolvimento de conceitos referentes à anatomia e fisiologia do sistema vestibular, assim como a compreensão das possíveis disfunções causadoras dessas patologias, em especial constatadas no processo de envelhecimento, são abordados considerando-se uma concepção ampla de saúde. A pesquisa de campo foi realizada através da aplicação de entrevistas envolvendo nove idosos, com idade acima de 65 anos, que possuem a disfunção vestibular, recebem atendimento médico de urgência e realizam a fisioterapia domiciliar com profissionais da MEDMAR/FAMILY Atendimento de Urgência Médica, localizada na Cidade de Santos, no Estado de São Paulo. Estes idosos vivem com suas famílias, as quais também foram entrevistadas. Adotando-se procedimentos metodológicos próprios da pesquisa qualitativa foi feita, inicialmente, a caracterização do estágio da disfunção vestibular dos sujeitos, com base em diagnósticos médicos existentes. Através de roteiro semi-estruturado, procedeu-se à identificação da condição de vida pessoal e de convivência familiar e social, antes e depois do surgimento da doença. A análise dos dados revela que a disfunção vestibular deve ser concebida como um dos elementos constitutivos do processo de envelhecimento e que os sintomas de manifestação deste acometimento devem ser devidamente compreendidos e cuidados pelo próprio pelo idoso e por seus familiares, considerando-se as repercussões reconhecidas nos depoimentos, tanto no convívio familiar como social

This lecture takes a dual-targeted approach in: 1) acquainting the audience with newer neuroimaging techniques applied to the consequences of vestibular dysregulation following noise or blast-induced mild traumatic brain injury (mTBI); and 2) considers treatment and rehabilitation modalities of vestibular and balance dysfunction in order to help veteran’s resume normal activities-of-daily-living. Relevant examples from each targeted lecture will be provided. Intended Audience: Professionals interested in the area of vestibular and balance assessment, neuroimaging, and rehabilitation.

Objective:To describe the prevalence and impact of vestibular dysfunction and nonspecific dizziness diagnoses and explore their associations with traumatic brain injury (TBI) severity, mechanism, and postconcussive comorbidities among post-9/11 veterans. Setting:Administrative medical record data from the US Departments of Defense and Veterans Affairs (VA). Participants:Post-9/11 veterans with at least 3 years of VA care. Design:Cross-sectional, retrospective, observational study. Main measures:International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes for TBI, vestibular dysfunction, dizziness, and other commonly associated postconcussive conditions; Neurobehavioral Symptom Inventory. Results:Of the 570 248 post-9/11 veterans in this sample, 0.45% had a diagnosis of vestibular dysfunction and 2.57% had nonspecific dizziness. Those with either condition were more likely to have evidence of TBI (57.11% vs 28.51%) and reported more disruption from neurobehavioral symptoms. Blast and nonblast injuries were associated with greater symptom disruption, particularly in combination. Conclusions:There was a consistent, significant association between TBI and vestibular dysfunction or nonspecific dizziness, after controlling for sociodemographic factors, injury mechanism, and comorbid conditions. Given that most deployed post-9/11 veterans report blast and/or nonblast injuries, the need for prompt identification and management of these conditions and symptoms is clear.

No description available.