Using data from 617 Vietnam-era veterans, this study aimed to better understand the relationships between depression symptoms, post-traumatic stress symptoms, and overall marital quality. Results indicated that depression symptoms and PTSS each had a negative relationship with marital quality when considered individually. The association between depression symptoms and marital quality persisted when PTSS was accounted for. However, the significant association between PTSS and marital quality dropped out. Further, PTSS did not moderate the association between depression symptoms and marital quality. The current study suggests tha tdepression symptoms and PTSS overlap in relation to marital quality among Vietnam-era veterans, with depression symptoms playing a major role. Future research should address samples across various age groups, different war campaigns, and among veterans with higher levels of clinical distress.