Thesis (Ph. D.)--Virginia Polytechnic Institute and State University, 1993. / Vita. Abstract. Includes bibliographical references (leaves 112-120). Also available via the Internet.

Yes / Combining information from optical coherence tomography (OCT) imaging and visual field testing is useful in the clinical assessment and monitoring of patients with glaucoma. Measurements of retinal nerve fibre layer thickness or neuroretinal rim width taken around the optic nerve head may be related to the visual field using a structure–function map. In this review, the structure–function mapping methods in clinical use are discussed. Typical clinical maps provide a population average, ‘one size fits all’ representation, but in recent years methods for customising structure–function maps to individual eyes have been developed and these are reviewed here. In the macula, visual field stimuli stimulate photoreceptors for which associated retinal ganglion cells are peripherally displaced. Recently developed methods that relate OCT measurements to visual field test locations in the macula are therefore also reviewed. The use of structure–function maps to relate OCT measurements to localised visual field sensitivity in new applications is also explored. These new applications include the selection of visual field test locations and stimulus intensities based on OCT data, and the formal post‐test combination of results across modalities. Such applications promise to exploit the structure–function relationship in glaucoma to improve disease diagnosis and monitoring of progression. Limitations in the validation and use of current structure–function mapping techniques are discussed. / >Heidelberg Engineering >Australian Research Council. Grant Number: LP130100055 >College of Optometrists. Grant Number: College of Optometrists Research Fellowship

After an intelligence test battery, the sixty right-handed subjects (30 males, 30 females) performed two visual field (VF) reaction time (RT) tasks requiring odd-even judgments concerning the whole numbers 1 through 8. Numbers were presented as words, a right VF left-hemisphere (LH) advantage task, or as bargraphs, a left, VF right-hemisphere (RH) advantage task, the height of the bargraphs indicating the number.

Purpose: To determine if patients with migraine show clinically apparent visual field deficits in the peripheral visual field compared to healthy controls. Methods: Normal observers (n=25; mean age 41 y, range 15-67 y) and patients with migraine (n=12, mean age 48 y, range 21-55 y) were examined with a fully automated kinetic perimetry program (Octopus 900, Haag-Streit, Switzerland) on two separate study visits within two weeks. The program examined 3 isopters (I4e, I2e, I1e) at stimulus velocities of 5°, 4°, and 3°/s respectively. For every isopter, 12 stimulus vectors were presented at meridians spaced 30° apart, in random order, and each isopter was measured 3 times. Patients with migraine had been diagnosed by a neuro-opthalmologist according to criteria of the International Headache Society. Results: Differences in mean isopter radius between migraine observers and healthy controls were small (< 1.3°) and not statistically significant (P>0.05, Mann-Whitney U). No learning or practice effects were observed between study visits, and AKP showed reasonable repeatability for all three isopters. Conclusion: Patients with migraine did not demonstrate decreased peripheral visual fields in comparison to controls. This study had sufficient power (90%) to detect a group difference in mean isopter radius of approximately 2°.

Thesis--Gothenburg University. Extra t.p. with thesis statement inserted. / Includes bibliographical references (p. 60-63).

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2008. / Härtill 4 uppsatser.

Thesis (Ph. D.)--Cornell University, May, 2008. / Vita. Includes bibliographical references (leaves 147-159)

Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 189-196).

Orientadores: Vital Paulino Costa, Jose Paulo Cabral de Vasconcellos / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-10T20:41:36Z (GMT). No. of bitstreams: 1 PierreFilho_PaulodeTarsoPonte_D.pdf: 3436232 bytes, checksum: b12cfb5d9f75e955568b115e88f61e29 (MD5) Previous issue date: 2008 / Resumo: O objetivo deste estudo foi avaliar a sensibilidade e a especificidade da perimetria de freqüência dupla (FDT), Tendency-Oriented Perimetry (TOP), SITA Standard (SS) e SITA Fast (SF) para o diagnóstico de glaucoma em indivíduos submetidos ao exame de perimetria computadorizada pela primeira vez. Sessenta e quatro pacientes glaucomatosos e 53 indivíduos normais, que nunca haviam realizado exame de campo visual, foram submetidos à perimetria computadorizada com as estratégias screening C-20-5 (FDT), G1 (TOP), SS e SF (programa 24-2), no mesmo dia, com intervalo de 15 a 30 minutos. A ordem dos exames foi aleatória para cada indivíduo, avaliando-se somente um olho por paciente. O diagnóstico de glaucoma baseou-se na presença de lesão típica de disco óptico e pressão intra-ocular (PIO) = 21mmHg. Para definir campo visual anormal, utilizaram-se três critérios para SS e SF e dois critérios para TOP e FDT, todos já descritos na literatura. Perimetrias SITA (SS e SF) foram considerados anormais quando: 1) O GHT (glaucoma hemifield test) era borderline ou fora dos limites da normalidade (outside normal limits); 2) O gráfico de probabilidade do pattern deviation apresentava três pontos adjacentes, não periféricos, de baixa sensibilidade com probabilidade menor de 5% de não ser percebido por população normal da mesma idade (p<5%) com um dos pontos com p<1%; 3) O PSD (¿pattern standard deviation¿) apresentava valor encontrado em menos de 5% (p<5%) da população normal de mesma idade. TOP foi considerado anormal quando: 1) O MDe (mean defect) > 2dB e/ou LV (loss variance) >6dB; 2) Havia sete pontos, sendo três deles adjacentes, com redução de sensibilidade = 5dB no gráfico de comparações corrigidas (corrected comparisons). FDT foi considerada anormal quando: 1) Havia uma área alterada (p<5%, p<2% ou p<1%); ou 2) Havia duas ou mais áreas alteradas, independente da profundidade do defeito. Realizaram-se análises comparativas da sensibilidade e especificidade de cada critério para o diagnóstico de glaucoma, incluindo: 1) Todos os exames independentemente da ordem de realização; 2) Somente os primeiros exames. Compararam-se também o tempo requerido para cada teste e a porcentagem de exames não confiáveis. O FDT foi o teste que requereu menor tempo para ser realizado, seguido por TOP, SF e SS (p<0,0001). Pacientes glaucomatosos apresentaram maior tempo de teste (p<0,05), mas não houve diferença estatisticamente significante em relação a porcentagem de exames não confiáveis quando comparados com indivíduos normais (p>0,05). As sensibilidades variaram de 87,5 a 89,1% para SS, 92,2 a 93,8% para SF, 87,5 a 89,1% para TOP e 82,8 a 85,9% para FDT (p=0,34). As especificidades variaram de 73,6 a 83% para FDT, 56,6 a 62,3% para TOP, 60,4 a 69,8% para SF e 66 a 71,7% para SS. A especificidade obtida com o critério 2 do FDT (baseado na presença de duas ou mais áreas anormais independente da severidade) foi significativamente mais alta que as medidas com outras estratégias (p<0,01). Quando somente os primeiros exames foram comparados, as sensibilidades foram de 78,6% para FDT, 94,1% para TOP, 89,5% para SS e variou de 92,7 a 100% para SF (p=0,63). As especificidades foram 76,9% para FDT, e variaram de 53,9 a 61,5% para TOP, de 57,1 a 71,4% para SF e 76,9 a 84,6% para SS (p=0,65). Concluiu-se que, quando testamos indivíduos sem experiência perimétrica, moderadas sensibilidades e especificidades são esperadas, qualquer que seja a estratégia escolhida / Abstract:The aim of this study was to evaluate the sensitivity and specificity of the screening mode of Frequency-Doubling Technology (FDT), Tendency-Oriented Perimetry (TOP), SITA Standard (SS) and SITA Fast (SF) for the diagnosis of glaucoma in perimetrically inexperienced individuals. One eye of 64 glaucoma patients and 53 normal subjects who had never undergone automated perimetry were tested with programs C-20-5 (FDT), G1 (TOP), and 24-2 (SS and SF), during a single visit on the same day. The order of tests was randomly assigned for each subject, with an interval of approximately 15-30 minutes. The gold standard for the diagnosis of glaucoma was based on the presence of a typical glaucomatous optic disc appearance, and intraocular pressure (IOP) = 21mmHg. To define an abnormal visual field, we applied three criteria for SS and SF and two criteria for TOP and FDT, all of them previously described in the literature. SS and SF results were considered abnormal if: 1) the glaucoma hemifield test (GHT) was borderline or outside normal limits; 2) if the pattern deviation probability map showed a cluster of three or more nonedge points deviating at p<5%, one of which deviating at p<1%; or 3) if pattern standard deviation (PSD) was increased to values deviating at p<5%. The TOP test was considered abnormal: 1) if the mean defect (MDe) > 2dB and/or the loss variance (LV) > 6dB, and/or 2) if there were at least seven points (three of them contiguous) with a reduction in sensitivity of 5dB or more in the corrected comparisons graphic. FDT test results were considered abnormal if 1) there was the presence of at least one abnormal location (p<5%, p<2% or p<1%); and 2) there were two or more abnormal locations regardless of the severity of abnormal points. Comparative analyses of the sensitivities and specificities of each criterion were carried out, including 1) All the exams regardless of the order of application; 2) Only the first exams. Comparative analyses of times for test completion and percentage of unreliable tests were also performed. FDT showed the shortest mean test duration, followed by TOP, SF and SS (p<0.0001). Glaucomatous patients had longer test times (p<0.05), but not statistically significant more unreliable visual fields than normal subjects for all tests (p>0.05). Sensitivities ranged from 87.5 - 89.1% for SS, 92.2 - 93.8% for SF, 87.5 - 89.1% for TOP and 82.8 - 85.9% for FDT (p=0.34). Specificities ranged from 73.6 - 83% for FDT, 56.6 - 62.3% for TOP, 60.4 - 69.8% for SF and 66 - 71.7% for SS. The specificity obtained with criterion 2 for FDT (based on the presence of two or more abnormal locations regardless of the severity of abnormal points) was higher than those measured with the other strategies (p<0.01). When only the first exams were compared, sensitivities were 78.6% for FDT, 94.1% for TOP, 89.5% for SS, and varied between 92.7 and 100% for SF (p=0.63). Specificities were 76.9% for FDT, and in the range of 53.9 - 61.5% for TOP, 57.1 - 71.4% for SF and 76.9 - 84.6% for SS (p=0.65). In conclusion, when testing individuals with no perimetric experience, moderate sensitivities and specificities should be expected, regardless of the strategy chosen / Doutorado / Oftalmologia / Doutor em Ciências Médicas

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