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The influence of vitamin D3 supplementation on the components of the metabolic syndromeWolberg, Charlene 03 1900 (has links)
Thesis (MNutr)--Stellenbosch University, 2013. / ENGLISH ABSTRACT: The possible advantages of vitamin D supplementation on various cardiometabolic conditions
have been examined over the past few years. Vitamin D supplementation has possibly shown
effects on each of the individual components of the metabolic syndrome i.e.: obesity,
hypertension, dyslipidaemia and glucose intolerance. The aim of this systematic review was to
ascertain whether or not vitamin D supplementation has any effect on any of the components
of the metabolic syndrome. We searched the (Cochrane Central Register of Controlled Trails
(Central), Medline, Science direct, ISI Web of knowledge and Scopus during 2010 (repeated
search in 2012). We found four randomized controlled trials that met our inclusion and
exclusion criteria. Three hundred and seventy three patients were included in these four
randomized controlled trails comparing vitamin D supplementation with placebo. Duration of
treatment was a minimum of 4 weeks, through to a maximum of on-year. The different trials
looked at various components of the metabolic syndrome as outcomes. The results were not
consistent amongst the trials and the results could not be combined in a meta-analysis due to
heterogeneity in study design and outcomes measured. The current systematic review
highlights the shortcomings in the published data and we recommend further trials be
undertaken before vitamin D supplementation can be recommended as beneficial for patients
with the metabolic syndrome. / AFRIKAANSE OPSOMMING: Die moontlike voordele van vitamien D-aanvullings op verskillende kardiometaboliese
toestande is oor die afgelope paar jaar ondersoek. Daar is aangetoon dat vitamien Daanvullings
uitwerkings het op elk van die individuele komponente van die metaboliese
sindroom naamlik vetsug, hipertensie, dislipidemie en glukose-intoleransie. Die doel van hierdie
sistematiese oorsig was om vas te stel of vitamien D-aanvullings enige uitwerking het op enige
van die komponente van die metaboliese sindroom of nie. Ons het gedurende 2010 soektogte
uitgevoer op die Cochrane Sentrale register van gekontroleerde proewe (Central), Medline,
Science Direct, ISI Web of Knowledge en Scopus (soektog is in 2012 herhaal). Ons het vier
verewekansigde gekontroleerde proewe wat aan ons insluiting- en uitsluitingskriteria voldoen
het, opgespoor. Driehonderd drie en sewentig pasiënte is by die vier proewe ingesluit. Al vier
proewe het vitamien D-aanvullings met plasebo vergelyk. Die duur van behandeling het van 4
weke tot een jaar gestrek. Die verskillende proewe het gekyk na verskillende komponente van
die metaboliese sindroom as uitkomste. Die resultate van die onderskeie proewe was nie
konsekwent nie. Die huidige sistematiese oorsig belig die tekortkominge in die gepubliseerde
data en ons beveel aan dat verdere proewe onderneem word om vas te stel of dit nuttig is om
vitamien D aanvullings vir pasiënte met die metaboliese sindroom aan te beveel, en of dit dalk
skadelik kan wees.
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Environmental factors in multiple sclerosis susceptibility and outcome : a focus on vitamin DOrton, Sarah-Michelle January 2008 (has links)
No description available.
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Vitamin D and influenza in school childrenKam, May-sin., 甘美倩. January 2010 (has links)
published_or_final_version / Community Medicine / Master / Master of Public Health
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Studies on the role of vitamin D in asthma patients from a South Florida pulmonary practiceUnknown Date (has links)
Vitamin D insufficiency/deficiency is widespread in asthma, and epidemiological studies point to an association between low serum 25-hydroxyvitamin D level and poor asthma control and increased severity. In humans. Vitamin D is principally derived from sunlight induced cutaneous conversion of 7-dehydrocholesterol to vitamin D and oral supplementation. We sought to determine if established and chronic-persistent adult asthma patients from a South-Florida pulmonary patient population, with abundant sunshine availability and oral vitamin D supplementation exhibit vitamin D insufficiency/deficiency. A trend to vitamin D insufficiency was observed in approximately 65% of both adult asthma patients and apparently healthy (non-asthmatic) volunteers. . The transcription factors required for Th9 conversion, PU.1 and IRF-4, were down-regulated by vitamin D. The generation of Th9 cells was inhibited equally by vitamin D and dexamethasone when used alone, but the effect was additive when both steroids were used in combination. Our studies using non-specifically stimulated cells were extended by analyzing the effect of vitamin D on allergen specific stimulation. The response of CD4+ T cells obtained from the blood of house dust mite positive asthmatics was studied. House dust mite allergen elicited a classical Th2 phenotype response (IL-4, IL-5, IL-9, and IL-13 cytokine profile) and vitamin D effectively inhibited those key Th2 cytokines. We conclude that vitamin D appears to be of significant clinical benefit in our cohort of patients, i.e., established chronic adult human asthma, by down-regulating key immune cells including Th9, Th17, and Th2 involved in this disorder. / by Amjad Munim. / Thesis (Ph.D.)--Florida Atlantic University, 2013. / Includes bibliography. / Mode of access: World Wide Web. / System requirements: Adobe Reader.
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