South Africa, as one of the world’s largest gold producing countries, also generates large amounts of tailings. These tailings are disposed in tailings dams, which pose great threat to the environment in the case of failure, in particular, liquefaction. In order to evaluate the potential of liquefaction, the void ratio of the tailings is required and is often impossible to obtain. Seismic methods allow an indirect method to estimate void ratio of in situ deposits of which tailings are examples of. Currently, the use of seismic methods to estimate void ratio of tailings rely on shear wave velocity – void ratio relationships derived for sands. It is thus uncertain whether this relationship holds for gold tailings, which is classified as a sandy silt or silt. The measurement of shear wave velocity of tailings is done in the laboratory using a triaxial apparatus modified to accommodate bender element. Shear wave velocities are measured using wide square pulses and continuous sinusoidal waves. The results show that there is a near linear relationship between void ratio and shear wave velocity normalized against effective stress. The position of this relationship lies below the previously published results for sands. Shear wave velocity of gold tailings is more sensitive to changes in effective stress than changes in void ratio or over-consolidation ratio. Furthermore, using phase sensitive detection of continuous waves, we can conclude that shear wave velocity of gold tailings is also frequency dependent. / Dissertation (MEng)--University of Pretoria, 2006. / Civil Engineering / MEng / Unrestricted

The Carboneras fault zone (CFZ, Almería Province, SE Spain) is a major NE-SW trending tectonic lineament that marks part of the diffuse plate boundary between Iberia and Africa. Developed within a basement terrain dominated by mica schist, the fault system comprises two main strands within a complex zone up to 1 km wide. Between these two strands is a braided network of left-lateral strike-slip, phyllosilicate-rich fault gouge bands, ranging between 1 and 20 m in thickness, passively exhumed from up to 3 km depth. The excellent exposure in a semi-arid environment, the wide range of rock types and fault structures represented and the practicality of carrying out in-situ geophysical studies makes this fault zone particularly well suited to verifying and interpreting the results of in-situ seismic investigations. Integration of elements of field study, laboratory analysis and modelling has aided interpretation of the internal structure of the fault zone. Ultrasonic measurements were made using standard equipment over confining and pore pressure ranges appropriate to the upper 10 km of the continental crust. Seismic velocities have also been approximated from modal analysis and mineral phase elastic properties and adjusted for the effects of porosity. In-situ seismic investigations recorded P-wave velocities 40-60% lower than those measured in the laboratory under corresponding pressures and at ambient temperatures for hard rock samples. Fault gouge velocities measured in the laboratory, however, are comparable to those measured in the field because, unlike the host rocks, fault gouges are only pervasively micro-fractured and lack the populations of long cracks (larger than the sample size) that cause slowing of the velocities measured in the field. By modelling the effect of fractures on seismic velocity (by superimposing upon the laboratory seismic data the effects of crack damage) the gap between field- and laboratory-scale seismic investigations has been bridged. Densities of macroscopic cracks were assessed by measuring outcrop lengths on planar rock exposures. Assuming crack length follows a power law relation to frequency, this fixes a portion of the power spectrum, which is then extrapolated to cover the likely full range of crack sizes. The equations of Budiansky and O'Connell (1976), linking crack density to elastic moduli, were used to calculate modified acoustic velocities, and the effects of the wide range of crack sizes were incorporated by breaking the distribution down into small sub-populations of limited range of crack density. Finally, the effect of overburden pressure causing progressively smaller cracks to close was incorporated to predict velocity versus depth of burial (i.e. pressure). Determination of rock physical properties from laboratory analysis and sections constructed from geological mapping provides a representation of velocity from selected parts of the Carboneras fault zone. First break tomography images show particularly well the location of steeply-inclined fault cores, and these correlate generally well with geological mapping and laboratory velocity measurements corrected for the effect of cracks. The decoration of the fault zone with intrusive igneous material is well correlated with the results of geological observations. Comparisons made between the field (seismic) inversion model and laboratory forward velocity model in El Saltador valley show the laboratory and field velocity measurements made within the fault zone can be reconciled by accounting for the effects of crack damage in field data.

BACKGROUND Vascular calcification is a major risk factor for cardiovascular morbidity and mortality in patients with end stage renal disease (ESRD). In Western countries, Blacks with ESRD appear to have lesser degrees of vascular calcification compared to non-Blacks. However, there is no published data on the association of ethnic differences in vascular calcification and survival in ESRD from Sub-Saharan Africa. METHODS This study assessed the 5-year change in vascular calcification and mortality in a previously published cohort of patients with ESRD. Vascular calcification was assessed by abdominal aortic calcification score (lateral abdominal radiograph) and vascular stiffness by pulse wave velocity. RESULTS Sixty-six of the original 74 participants, studied a baseline, were identified. The median age was 46.6 years (37.6-59.2) and 57.6% were women. Abdominal aortic calcification showed no progression among Blacks [baseline range 0-5, follow up range 0-8 (p=1.00)], but a nonsignificant trend to progression among non-Blacks [baseline range 0-19, follow up range 0-22 (p=0.066)]. Black participants did not display a survival advantage (p=0.870). Overall, sepsis was the most common cause of mortality (64% of those with an identifiable cause of death). Non-Blacks had higher parathyroidectomy rates than Blacks with 9/30 cases compared to 2/36 (p=0.036). After adjustment for parathyroidectomy at follow up, the odds ratio of having abdominal vascular calcification score of ≥1 amongst non-Blacks was 8.6-fold greater compared to Blacks (p= 0.03). Central aortic systolic pressures (CASP) and pulse wave velocities (PWV) were higher in the study population than age matched normative values. At follow up, a positive correlation (r=0.3) was observed between PWV and abdominal aortic calcification (p=0.04). Elevated baseline coronary artery calcification score and FGF-23 level at baseline were not associated with a difference in mortality. CONCLUSION There was no significant progression in vascular calcification among Blacks. After adjusting for increased parathyroidectomy rates, there was a greater progression of vascular calcification amongst non-Blacks compared to Blacks highlighting possible ethnic differences in calcium phosphate metabolism in patients with ESRD. The lack of vascular calcification progression in Blacks was not however associated with improved survival, but the sample size was small.

The thesis is concerned with the analysis of measuring pulse wave velocity in human body with the aid of whole-body multichannel bioimpedance which was developed at ISI AS CR, v.v.i.. The evaluation of pulse wave velocity can provide us with important information about the state of vessel compliance which is one of the basic parameters informing on their physiological state. The examination of the state of vascular system is a very important part of early diagnostics because its pathological states are the main contributor to the rise of cardiovascular diseases and disease mortality. The thesis is concerned with the theoretical analysis together with the available methods of valuation of the state of vascular system that use measuring of pulse wave velocity. The main part of the thesis deals with the analysis of the whole-body multichannel bioimpedance measurement. The proposed and programmed protocol that summarizes and visualizes all obtained information is a part of this thesis. This is currently used as an output of the experimental measurement by this method. Data file for statistical processing contains the values of the pulse wave velocity of 35 healthy volunteers and subsequently the properties of pulse wave are assessed at various excitations.

L'élastographie par résonance magnétique (ERM) est une technique d'imagerie, reconnue comme une méthode pertinente pour la caractérisation mécanique des tissus humains in vivo. Celle-ci représente un intérêt fondamental en diagnostic clinique car le développement d'un processus pathologique s'accompagne la plupart du temps d'altérations des propriétés mécaniques des tissus atteints. L'ERM consiste à enregistrer le champ de déplacement induit au passage d'une onde de cisaillement généré dans le milieu étudié. Les paramètres mécaniques comme la vitesse, v, et les modules de viscoélasticité de cisaillement, G' et G'', peuvent être cartographiés. La quantification des paramètres mécaniques dépend à la fois de la fréquence mécanique, fexc, de la taille de voxel, a, de l'amplitude des champs de déplacement induits, A, de l'amplitude du rotationnel du champ de déplacement, q, des erreurs de mesure, ΔA et Δq, donc du rapport signal à bruit, RSB, et enfin de la méthode de reconstruction. En inversant les équations différentielles du champ de déplacement acquis selon les trois dimensions de l'espace, ces paramètres ont été considérés pour déterminer la précision et l'exactitude des modules mécaniques obtenus et établir les conditions de validité de l'ERM. Dans cette thèse, nous avons tout d'abord considéré A et A/ΔA afin de définir un premier seuil de validité pour l'ERM. Nous avons étudié l'influence de ces deux paramètres sur un fantôme hétérogène dans un appareil IRM 1,5 T avec deux types d'antennes. Dans une première étude, les champs de déplacement ont été acquis en fonction de A en utilisant deux séquences écho de spin (RFE) et écho de gradient (FFE) sensibilisées au mouvement pour une taille de voxel isotrope de 1 mm. Dans une seconde étude, ils ont été acquis en RFE en fonction de A pour trois résolutions spatiales différentes. Ces études ont révélé l'existence d'un seuil en A/ΔA au-delà duquel les paramètres extraits (G', G'') atteignent un plateau et l'ERM est fiable. Nous avons ensuite considéré le nombre de voxel par longueur d'onde, λ/a, comme paramètre déterminant des conditions de validité de l'ERM et nous avons caractérisé la qualité des données acquises par le rapport q/Δq. Sur des simulaitons dans un milieu élastique, homogène et isotrope avec un RSB variant entre 5 et 30, la précision et l'exactitude des mesures se sont avérées optimales pour 6 à 9 voxels par longueur d'onde. Nous avons reproduit expérimentalement à 2 kHz les conditions des siimulations sur un fantôme de PVA. Les champs de déplacement ont été acquis à 11,7 T en utilisant une séquence RFE sensibilisée au mouvement pour des résolutions spatiales de 150 μm à 300 μm afin de balayer le rapport λ/a de 1 à 20. Les résultats expérimentaux confirment pleinement les prédictions de la simulation. La vitesse de cisaillement diminue et tend vers la vitesse de référence attendue lorsque l'acquisition est réalisée dans le domaine optimal, à savoir ici lorsque a est inférieure ou égale à 200 μm. En outre la dispersion de la vitesse est réduite dans le domaine optimal et des estimations plus précises des paramètres mécaniques ont pu être déduites. Cette thèse montre d'une part que la précision et l'exactitude de l'ERM sont optimales lorsque les acquisitions sont réalisées ou traitées pour un domaine d'échantillonnage de la longueur d'onde déterminé par le RSB. Elle montre d'autre part que la comparaison des résultats obtenus doit être menée dans une gamme similaire de q/Δq. La prise en compte des conditions de validité de l'ERM, déterminées par les rapports λ/a et q/Δq, conduit à une mesure quantitative effective des paramètres mécaniques. Il est ainsi possible d'envisager un diagnostic clinique pertinent au sein d'un même organe, d'un même sujet, entre sujets ou au cours du temps. / Magnetic Resonance Elastography (MRE) is a imaging technique, recognized as a pertinent method for the mechanical characterization of human tissue in vivo. It offersa particular interest in clinical diagnosis because the development of a pathological process is often accompanied by modifications of the mechanical properties of diseased tissues. MRE consists of recording, along the three spatial dimensions, the displacement field induced by the propagation of a shear wave generated by excitation of the investigated tissue. Mechanical parameters such as shear wave velocity, v, and shear moduli, G' and G'', can then be mapped. The quantification of the mechanical parameters depends on the frequency of the mechanical excitation, fexc, the spatial resolution, a, the amplitude of the induced displacement field, A and the amplitude of the curl field displacement, q, with associated measurement errors, ΔA and Δq, (related to the signal-to-noise ratio, SNR) and finally the reconstruction method. All these parameters were considered to determine the precision and the accuracy of the estimated mechanical moduli and to establish the conditions of validity of MRE following the inversion of the differential equations of the displacement field. In this work, first A and A/ΔA were considered to define a validity threshold for MRE. The influence of A and A/ΔA was studied on a heterogeneous phantom acquired using a 1.5 T MRI with two different types of coils. In a first study, the displacement fields were acquired as a function of A using motion-sensitized spin-echo (REF) and gradient-echo (FFE) sequences for an isotropic spatial resolution of 1 mm. In a second study, the displacement field was acquired as a function of A using RFE for three different spatial resolutions. These studies revealed the existence of a threshold in A/ΔA beyond which the extracted parameters (G', G'') reach a plateau and the MRE is reliable. Then the number of voxels per wavelength, λ/a was considered as a parameter determining the conditions of validity of MRE. This parameter was studied according to the quality of the acquired data characterized by the ratio q//Δq. Simulations were carried in a homogeneous and isotropic elastic medium with a SNR between 5 and 30. The accuracy and the precision of the measurements were found optimal for 6 to 9 voxels per wavelength. The simulation conditions were experimentally reproduced at 2 kHz on a home-made polyvinyl alcohol phantom. The displacement fields were acquired at 11.7 T using a motion-sensitized RFE sequence with spatial resolutions ranging from 150 μm to 300 μm in order to obtain a λ/a ratio ranging from 1 to 20. The experimental results fully confirm the predictions of the simulation. The shear wave velocity decreases with λ/a. It tends towards the expected reference value when the acquisition is performed in the optimal condition, namely here when a is less than or equal to 200 μm. In addition, the standard deviation of the shear wave velocity is reduced for the optimal conditions. Therefore, accurate estimation of mechanical parameters could be deduced. This thesis first demonstrates that the precision and accuracy of MRE are optimal when the acquisitions are performed or processed for a certain wavelength sampling range determined by the SNR. We also showed that for fair comparison of the results, MRE must be carried out in a similar range of q/Δq. Taking into account the conditions of validity of MRE, determined by the ratios λ/a and q/Δq, leads to an effective quantitative measurement of the mechanical parameters making it possible to establish a relevant clinical diagnosis within the same organ, the same subject, between subjects or over time.

Structural and petrophysical analysis have been conducted within the Melechov massif with focus on structures controlling the porosity, permeability and thermal conductivity of the rock. The structure of the massif has been constrained based on extensive dataset including AMS and field structural measurements of ductile and brittle structures. Maps and stereograms have been constructed to display the magnetic fabrics and the fracture system of the studied massif. The fracture system of the massif has been described by two principal and two supplementary sets of joints and by faults formed mainly by joint reactivation or less frequently formed as shear fractures. The measured petrophysical data have been used to characterize the effect of fracturing and alteration on pore space geometry and in turn on permeability, thermal conductivity and elastic properties of the studied granite. Distinct petrophysical properties have been identified for pristine granite, for fractured fresh granite as well as for fractured granite altered by Fe-oxide, chlorite and clay minerals. Relations between the measured petrophysical properties have been explained in terms of evolution of the rock pore space. A detailed microstructural study combined with multidirectional P-wave velocity measurements at high confining pressure and...

Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; P<0.001). In conclusion, gallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.

The Multichannel Analysis of Surface Waves (MASW) method traditionally uses an array of collinear vertical geophones to measure seismic wave propagation velocity at discrete points along the ground surface. Distributed fiber optic sensors (FOS) measure the average longitudinal strain over discrete lengths (i.e., zones) of a buried fiber optic cable. Such strain measurements can be used to assess ground motion and thus analyzed with the MASW method. To evaluate the feasibility of using FOS strain measurements in the MASW method, field experiments were conducted with both FOS and surface vertical geophones. Synthetic seismograms were also used to compare FOS to vertical and horizontal geophones and investigate the effect of installation depth and sensor type. Through the MASW method, shear wave (Vs) profiles from the FOS showed comparable results to those obtained with the geophones and achieved the same degree of uncertainty from the non-uniqueness of the MASW inversion process.

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