Thesis (Ph.D.)--Aberdeen University, 2009. / Title from web page (viewed on Sep. 2, 2009). Includes bibliographical references.

Thesis (doctoral)--University of Göteborg, 1986. / Extra t.p. with thesis statement inserted. Includes bibliographical references.

This thesis demonstrates my original contribution to the specialty of -wound healing as it has evolved over the past twenty years. It comprises three projects through which I present and illustrate a selection of the work I have carried out as a researcher, clinician and educator in wound healing, and the relationship between these areas. This thesis begins with Project One, which discusses my contribution to wound healing research. Project Two explores the ways I have used die outputs of research in developing -wound care practice within the context of a specialist wound healing unit. Project Three illustrates how I have utilised die outputs of research as the basis for educational materials. It is through engaging in a diverse range of activities in these three areas that I have been able to make a unique contribution to -wound healing nursing. In each of the projects die portfolio materials are discussed with reference to a number of theoretical frame-works. In Project One I use a hierarchical approach (Sackett et al, 1991, 2000) to explore my contribution to research. In Project Two I adopt die role definition approach developed by Hamric, Spross and colleagues (1983, 1989, 1996, 2000) in exploring my contribution to developing -wound care practice. Finally, in Project Three I utilise Benner's research on professional development (Benner, 1984) as a frame-work on -which to display my materials. While I have been writing this diesis I have reflected on twenty years experience in wound care nursing. This opportunity has facilitated me in planning for my future career in the specialty of -wound healing, and in making decisions about where I expect to focus my attention in the future.

No description available.

No description available.

Dissertation submitted to the Faculty of Health Sciences of the University of the Witwatersrand, Johannesburg in fulfilment of the requirement for the degree of Master of Science in Medicine Johannesburg 2014 / silver (NCS) dressings have antimicrobial and anti-inflammatory effects which aid healing, particularly in burns and chronic wounds. However, they are cytotoxic and may delay healing in acute wounds. Therefore, this study aimed to assess the effect of a NCS dressing on wound healing in full-thickness excisional wounds in a porcine model. Healing of porcine skin was assessed on day 3, 6, 9 and 15 post-wounding. Five wounds dressed with NCS and five untreated wounds dressed with polyurethane film (the control) were assessed per day (n=40 wounds). The rate of healing was measured using digital photographs. The inflammatory response, restoration of the epithelium and blood vessel formation were evaluated using haematoxylin and eosin stained sections. Picrosirius red staining and confocal microscopy were used to assess collagen formation. Proliferation of keratinocytes was calculated using sections immunolabelled for Ki-67. Additionally, the quality of the re-epithelialised wounds was assessed using a Clinical Assessment Score. There was no difference in the rate of healing between wounds treated with NCS and those dressed with polyurethane film. Inflammation was increased in NCS-treated wounds on day 3 post-wounding. However, compared to controls, on day 15 post-wounding the epithelium of NCS-treated wounds more closely resembled normal epithelium. Additionally, a greater number of mature blood vessels were seen in NCS-treated wounds. Differences were also observed in the deposition of collagen in NCS-treated wounds compared to controls. These results suggest that NCS may be beneficial for scar formation. Further investigation is needed into the effect of NCS and its role in the treatment of wounds, including novel uses such as the prevention of scarring.

The material characteristics play a role in the suitability of chitosan for biomedical applications. This is not surprising since the degree of deacetylation of chitosan influences antimicrobial activity, degradation rate, immune reaction and mechanical properties such as strength and elongation. This study examines chitosans of variable material characteristics for wound and bone healing applications. Chitosan films of 76, 78, 80, 87, 91, 92, and 95% degree of deacetylation were tested in vitro for cellular responses by fibroblast and bone cell lines. The in vitro responses were compared to the material characteristics of molecular weight, degree of deacetylation, swelling index, and ash content.

Thesis (M.S.)--University of Michigan, 1981.

Thesis (M.S.)--University of Michigan, 1989.

Thesis (M.S.)--University of Michigan, 1975.