X-ray and neutron computed tomography (CT) have been used successfully for the non-destructive imaging of artifact in art conservation. These applications range from object investigations to the use of micro-focus CT for experimental studies. While there is precedent for the use of CT in art conservation, the method is still limited in application partially due to restricted access to facilities and the high cost of producing publishable results. The purpose of this study was to identify alternative CT methods including the use of different radiation sources and industrial imaging system. Both investigations of the use of low-flux neutron CT at the Royal Military College in Kingston compared to high-flux neutron CT at the Advanced Neutron Tomography And Radiography Experimental System (ANTARES) at FRM-II in Garching, Munich and the use of megavoltage gamma ray computed tomography at Kingston General Hospital in Kingston successfully imaged the corroded metal artifacts. The artifacts investigated were from the Diniacopoulos Collection at Queen’s University and were underwater concretions of L’Anse aux Bouleaux provided by Parks Canada. This study also evaluated the Xradia XCT-400 for comparison to similar systems used in conservation. This evaluation also provided successful images of corroded metal coins from the Diniacopoulos Collection for use in identification. To address the issue of cost prohibitive image analysis programs, a workflow using the open-source software programs ImageVis3D, 3DSlicer and ImageJ was developed. This workflow would enable researchers and conservators to produce publishable images and analyze the information in the CT data sets. Additionally, this workflow addresses some common research questions that might arise during investigations that would guide conservators in optimizing their imaging parameters and image analysis. The combination of the alternative radiation sources and the open-source workflow allows for greater accessibility of CT for conservators and researchers. While the preliminary success of the study is promising, more research is needed to optimize the scanning parameters and image analysis through the use of phantoms and comparisons to traditional investigative methods in conservation. / Thesis (Master, Art Conservation) -- Queen's University, 2011-09-09 14:25:25.219

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<p><font face="Arial"> <p align="left">In this study, the capabilities of Neutron Radiography (NRad) and -Tomography (NTomo), as well as X-ray Radiography (XRad) to investigate chlorides and chlorides corrosion effects within steel reinforced laboratory concrete samples are practically explored. Capabilities of Scanning Electron Microscopy (SEM), Prompt Gamma Neutron Activation Analysis (PGNAA), Particle Induced X-ray Emission (PIXE), Small-Angle Neutron Scattering (SANS), Neutron Diffraction (NDIFF) and X-ray Diffraction (XDIFF) analytical techniques are also explored through review of literature.</p> </font></p>

Supernova explosions are among the most energetic events known in the universe, leaving supernova remnants (SNRs) as their relics. The cores of massive stars collapse to form neutron stars, among the most compact and strongest magnets in the cosmos. The thesis studies a sample of such magnetic "beauties" in X-rays, the magnetars and high-magnetic field pulsars (HBPs), with the motivation to understand their evolutionary links. We also address the connection between these sources by investigating their environs through their securely associated SNRs. Magnetars have ultra-high magnetic fields B ~ 10^{14} - 10^{15} Gauss (G) and include the soft-gamma repeaters (SGRs) and anomalous X-ray pulsars (AXPs). The HBPs have magnetic fields B ~ 10^{13} - 10^{14} G, intermediate between the classical rotation-powered pulsars (B ~ 10^{12} G) and magnetars. We focussed on two HBPs: J1119-6127 and J1846-0258, with similar spin-properties and associated with the SNRs G292.2-0.5 and Kes 75, respectively. In our studies, magnetar-like behavior was discovered from the Crab-like pulsar J1846-0258, clearly establishing a connection between the HBPs and magnetars for the first time, while no such behavior has been observed from PSR J1119-6127 so far. J1119-6127's overall X-ray properties together with its compact pulsar wind nebula resemble more the classical rotation-powered pulsars. We studied two magnetars, one from each sub-class: SGR 0501+4516 and AXP 1E 1841-045. The spectral and statistical analysis of the bursts and the persistent X-ray emission properties observed from them were found consistent with the magnetar model predictions as well as those seen in other SGRs. Finally, we probed the environment of these stellar magnets by performing a detailed X-ray imaging and spatially resolved spectroscopic study of two SNRs: G292.2-0.5 and Kes 73 associated with J1119-6127 and 1E 1841-045, respectively. We found that both SNRs point to very massive progenitors (>~25 solar masses), further supporting the growing evidence for magnetars originating from massive progenitors using other multiwavelength studies.

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This thesis reports on a novel use of the Medipix All Resolution System (MARS) Spectral CT scanner as a platform of small animal irradiation. Irradiation from the x-ray source in the scanner was used to inhibit the growth and recovery of neurons in rats. The goal is to extrapolate the relationship between stem cells and memory and functional behaviours. Specific developments were carried out prior to the irradiation of live rats. A live rat holder was designed and built to provide a setup stable enough for fixing the position of the rats head. This was achieved by integrating a three piece bar system into the holder to hold the head from both ears and nose. To quantify the absorbed dose, x-ray exposures were measured using a calibrated ion chamber and were used to generate a depth dose curve with sheets of Perspex layers and radiochromic films. This curve is presumed to simulate the dose inside the rat‘s head. To target a sub region of interest within the rat‘s brain, specific anatomical landmarks were investigated for the design of the lead collimators. The position of the sub volume, the hippocampus, was located through a combination of anatomical landmarks and x-ray transmission images of the rat‘s head. Bregma and the interaural line were used to numerically plot out the co-ordinates of the dorsal and ventral hippocampus which was then translated onto the lead collimators. The x-ray transmission images of euthanized rats were used as a guide to locate the dorsal and ventral hippocampuses. Bregma and the interaural line were the main anatomical landmarks which were used for the design of the lead collimators to be placed around the head. Three pilot rats were irradiated with the designed holder and collimators. The point dose to the hippocampus was calculated using the simulated depth dose curve. Post irradiation status of the neurogenesis was assessed three weeks after the treatment. However only one of the three rats showed a significant reduction in the number of neurons in the hippocampus emphasizing the room for more improvement in the physical setup of the irradiation.

The extra energy information provided by spectral x-ray imaging using novel photon counting x-ray detectors may allow for improved decomposition of materials compared to conventional and dual-energy imaging. The information content of spectral x-ray images, however, depends on how the photons are grouped together. This thesis deals with the theoretical aspect of optimising material discrimination in spectral x-ray imaging. A novel theoretical model was developed to map the confidence region of material thicknesses to determine the uncertainties in thickness quantification. Given the thickness uncertainties, photon counts per pixel can be optimised for material quantification in the most dose efficient manner. Minimisation of the uncertainties enables the optimisation of energy bins for material discrimination. Using Monte Carlo simulations based on the BEAMnrc package, material decomposition of up to 3 materials was performed on projection images, which led to the validation of the theoretical model. With the inclusion of scattered radiation, the theoretical optima of bin border energies were accurate to within 2 keV. For the simulated photon counts, excellent agreement was achieved between the theoretical and the BEAMnrc models regarding the signal-to-noise ratio in a decomposed image, particularly for the decomposition of two materials. Finally, this thesis examined the implementation of the Medipix detector. The equalisation of pixel sensitivity variations and the processing of photon counting projection images were studied. Measurements using the Medipix detector demonstrated promising results in the charge summing and the spectroscopic modes of acquisition, even though the spectroscopic performance of the detector was relatively limited due to electronic issues known to degrade the equalisation process. To conclude, the theoretical model is sufficient in providing guidelines for scanning parameters in spectral x-ray imaging and may be applied on spectral projection measurements using e.g. the redesigned MedipixRX detector with improved spectroscopic performance, when it becomes available.