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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Die Adsorption von Lipoproteinen an der Oberfläche fibrogener und inerter MineralstäubeBogatu, Bettina Ulrike 14 June 2004 (has links)
Sieben fibrogene und fünf nicht fibrogene (inerte) Mineralstäube wurden auf ihr Adsorptionsvermögen gegenüber Lipoproteinen untersucht. Die Adsorption erfolgte aus menschlichem Serum bzw. bovinem Lipoproteinkonzentrat. Die spezifischen Oberflächen der Stäube wurden mit Hilfe einer neuen Methode ermittelt, die auf der Adsorption von Nonadecansäure beruht. Sie vernachlässigt Oberflächenporen mit Öffnungsdurchmessern / Seven fibrogenic and five nonfibogenic (inert) mineral dusts were examined for their adsorption capacity for lipoproteins. Lipoproteins came from human serum and bovine lipoprotein- concentrate. The specific surface areas of the dusts were determined with the help of a new method, which is based on the adsorption of nonadecanoic acid. It neglects surface pores with opening diameters less than 2,5nm. The most important result is that fibrogenic dusts adsorb significantly more high density lipoproteins (HDL), than the inert dusts. The adsorption of HDL on quartz can be reduced up to 96% by addition of Polyvinylpyridine-N-oxide (PVPNO), an inhibitor of quartz- induced fibrosis. The HDL- adsorption might play a role during the developing process of mineral-dust-induced fibrosis.
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