In Arabidopsis, the F-box gene family encodes a large number of proteins postulated to act as substrate selectors for proteasome-mediated protein degradation. Recent reports document the importance of F-box proteins in developmental and metabolic signaling. Our microarray analyses of inflorescences of the brevipedicellus(bp) mutant indicate several F-box proteins are upregulated, suggesting that BP represses these genes in wild type plants to condition normal inflorescence development. We undertook analyses to examine the function of these proteins and their contribution to the pleiotropic phenotypes of bp. Yeast-2-hybrid screens revealed that the F-box protein At1g80440 binds to phenylalanine ammonia lyase-1(PAL1), the gateway enzyme of phenylpropanoid metabolism. Transgenic lines driven by the 35S cauliflower mosaic virus were attained but could not be propagated, suggesting a fatal phenotype. BP driven F-box expression results in phyllotaxy defects, manifest as alterations in the emergence of inflorescence and floral meristems in the axils of some cauline leaves.

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<p>Modular decompositions of protein interaction networks can be used to identify modules of cooperating proteins. The biological plausibility off these modules might be questioned though. This report describes how a modular decomposition can be completed with semantic information in the visual representation. Possible methods for creating modules of functionally related proteins are also proposed in this work. The results show that such modules, with advantage can be combined with modules from a graph decomposition, to find proteins that are likely to cooperate to perform certain functions in organisms</p>

Ulm, Univ., Diss., 2001.

Universiẗat, Diss., 2003--Köln.

University, Diss., 2005--Düsseldorf.

Universiẗat, Diss., 2005--Düsseldorf.

No description available.

No description available.

No description available.