Yes / Ynamide, is an understudied but attractive class of alkynes, activated by the donating ability of the nitrogen adjacent to alkynes. With the nucleophilicity on β-carbon and the electrophilicity on α-carbon of ynamides, this review summarizes the syntheses of ynamides and miscellaneous reactions - oxidation, rearrangement, cyclization, and cycloaddition to construct complicated heterocyclic rings. The synthetic methodologies were further applied into natural products synthesis, e.g. marinoquinolines A and C, aplidiopsamine A, rigidin A, and 7-azaserotonin derivative. / We thank National Science Foundation of China (NSFC) (21462004), State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (CMEMR2014-A04), 2015 GXNSFBA (139032), GXNU, and Newton International Fellowship granted by Royal Society.