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1	A Study On Values, Problems And Potentials Of The Traditional Dwellings In Karabaglar-mugla Timur, Baris Ali 01 March 2012 (has links) (PDF) Karabaglar district of Mugla, which was registered as a conservation site in 1977, is a low density traditional settlement which has had a family scale agricultural production background. Most of the families, living in the town center, used to migrate to their houses and their farms in that fertile district from the spring till the autumn in order to prepare their needs of foods for the winters as the production of family scale agriculture and animal husbandry. Today the district is located next to Mugla University campus in K&ouml / tekli district in the south and neighbors the axis relating university to the city center in the west. The land values in Karabaglar are very high because the area has always been a prestige zone for the citizens of Mugla because of its cultural and traditional background and the natural beauty. Unfortunately these characteristics lead either to rapid and unconscious restoration interventions or to the total abandoning of the traditional buildings to collapse in order to use the land in future. Therefore / Karabaglar is in danger of losing its traditional, urban, architectural and natural characteristics. This study seeks to fulfill the already made urban-scaled conservation studies with the architectural-scaled data. It aims to determine the values, problems and potentials of the traditional dwellings in Karabaglar-Mugla. NA Architecture 1-9428
2	Mutational Analysis of FERM Domain Proteins CG34347 and Cdep in Drosophila Milic, Milos 02 August 2012 (has links) Crumbs is a transmembrane protein and apical determinant in Drosophila epithelial cells. Its cytoplasmic tail contains a PDZ and a FERM domain-binding site through which Crumbs interacts with the FERM proteins Yurt, Moesin and Expanded. Recent evidence suggests that Crumbs can also interact with the uncharacterised FERM proteins CG34347 and Cdep. The main objective of my thesis was to generate mutations in CG34347 and Cdep to facilitate the functional analysis of these genes. I generated a mutation for Cdep that remains to be characterised and two mutant lines for CG34347; one lacking the first exon and one lacking the entire gene, using a FRT-based recombination strategy. Both CG34347 mutants cause severe ovarian defects. The most consistent defect is a multilayering of the interfollicular stalk. These defects are also observed when Notch, Hippo, Wingless and Hedgehog signalling pathways are overactive in ovaries suggesting that CG34347 participates in one of those pathways. Drosophila Cell Signalling Crumbs Polarity FERM Cell Signalling PatJ Armadillo Oogenesis Interfollicular stalk Notch Wingless Hedgehog Hippo Follicular epithelium Cell division Ovaries Yurt 0369 0307 0379
3	Mutational Analysis of FERM Domain Proteins CG34347 and Cdep in Drosophila Milic, Milos 02 August 2012 (has links) Crumbs is a transmembrane protein and apical determinant in Drosophila epithelial cells. Its cytoplasmic tail contains a PDZ and a FERM domain-binding site through which Crumbs interacts with the FERM proteins Yurt, Moesin and Expanded. Recent evidence suggests that Crumbs can also interact with the uncharacterised FERM proteins CG34347 and Cdep. The main objective of my thesis was to generate mutations in CG34347 and Cdep to facilitate the functional analysis of these genes. I generated a mutation for Cdep that remains to be characterised and two mutant lines for CG34347; one lacking the first exon and one lacking the entire gene, using a FRT-based recombination strategy. Both CG34347 mutants cause severe ovarian defects. The most consistent defect is a multilayering of the interfollicular stalk. These defects are also observed when Notch, Hippo, Wingless and Hedgehog signalling pathways are overactive in ovaries suggesting that CG34347 participates in one of those pathways. Drosophila Cell Signalling Crumbs Polarity FERM Cell Signalling PatJ Armadillo Oogenesis Interfollicular stalk Notch Wingless Hedgehog Hippo Follicular epithelium Cell division Ovaries Yurt 0369 0307 0379

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