Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-06-23T19:49:19Z No. of bitstreams: 1 EdianaPaulaRebitski_DISSERT.pdf: 5282849 bytes, checksum: f1a7a2f4009a400f77db6f24d30a9596 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-27T19:26:26Z (GMT) No. of bitstreams: 1 EdianaPaulaRebitski_DISSERT.pdf: 5282849 bytes, checksum: f1a7a2f4009a400f77db6f24d30a9596 (MD5) / Made available in DSpace on 2016-06-27T19:26:26Z (GMT). No. of bitstreams: 1 EdianaPaulaRebitski_DISSERT.pdf: 5282849 bytes, checksum: f1a7a2f4009a400f77db6f24d30a9596 (MD5) Previous issue date: 2015-05-22 / Bionanocomp?sitos s?o materiais nanoestruturados h?bridos org?nico-inorg?nico que envolvem uma contrapartida org?nica de origem biol?gica, por exemplo, um biopol?mero, associado a um s?lido inorg?nico em nanoescala. Materiais bioh?bridos a base de argilominerais (montmorillonita, sepiolita) e s?lidos inorg?nicos (hidr?xidos duplos lamelares) s?o uma boa op??o para diversas aplica??es (tais como biom?dicas) devido ao seu baixo custo, biodegradabilidade e biocompatibilidade. Devido a capacidade de troca i?nica, ?rea espec?fica elevada e a capacidade de adsor??o que esses materiais possuem, ? poss?vel combinar uma grande variedade de esp?cies org?nicas, tais como drogas, na qualidade de transportadoras. Neste contexto, este trabalho apresenta a prepara??o de novos bionanocomp?sitos com base na combina??o dos biopol?meros carboximetilcelulose e ze?na como revestimento do h?brido, argilomineral - antibi?tico e hidr?xidos duplos lamelares-antibi?tico. Para a s?ntese dos materiais bioh?bridos foi utilizado o antibi?tico neomicina de uso t?pico e amoxicilina de uso oral como f?rmacos modelos, o qual, foram incorporados nos argilominerais e hidr?xidos duplos lamelares por processo de intercala??o por troca i?nica e por adsor??o. / Bionanocomposites systems clay base (montmorillonite and sepiolite), layered double hidroxides and biopolymers (carboxymethylcellulose and zein) were evaluated as topical delivery systems with antibacterial activity and as oral delivery systems. For this study, neomycin, a topical antibiotic, indicated mainly for open wound infections. The drug amoxicillin, an antibiotic indicated mainly for throat infections, were also used in this study. Both antibiotics were used as model drugs. Initially, drugs were incorporated directly into the biopolymer matrix, comprising the combination of carboxymethylcellulos and zein, being conformed as movies and balls and evaluated for their antibacterial activity and controlled release simulating gastrointestinal fluids. Moreover, hybrids materials have been prepared where the neomycin drug was incorporated into the lamellar inorganic solids, such as montmorillonite by ion exchange reaction, and the fibrous type, such as sepiolite by adsorption in aqueous solution. But the drug amoxicillin was incorporated into layered double hydroxides by anion exchange and montmorillonite by cation exchange. The resulting hybrids were in turn combined with the biopolymer matrix yielding bionanocomposites shaped materials such as films were tested for their antibacterial activity, and the shaped materials beads were tested for their release in the gastrointestinal fluids. Through the analysis of various physico-chemical techniques, we observed the interactions between the studied materials, the formation of hybrids materials, obtaining the bionanocomposites materials and material efficiency when applied in controlled release of drugs both topical and use oral mainly influenced by the presence of zein, are promising as topical delivery systems and oral drugs.