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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Induction of Active Immune State by Multinucleate Tumor Cells in Mice

Liao, Shuen-Kuei 03 1900 (has links)
<p> Transplantable methylcholanthrene induced tumor was studied in relation to tumor immunity in its syngeneic hosts, A/Jax mice, The tumor was characterized by cytogenetic, histological and electron microscopic procedures, A technique was developed to establish a state of active immunity by immunizing animals with Sendai virus fused tumor cells. The specificity of immunoprotection was determined by the resistance to the challenges with viable tumor cells and the delayed hypersensitivity test. Adoptive transfer of anti-tumor immunity and cellular response of lymphoid cells from immunized mice were followed to examine the expression of cell-mediated reactions. Circulating antibody of the immune serum was demonstrated by immunofluorescent technique and the enhancing effect on the growth of the transplanted tumor. The relationship of these results to the current knowledge of tumor immunology was discussed </p>. / Thesis / Doctor of Philosophy (PhD)

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