Abstract Low wage is seemed to be the powerful weapon of the firms in China and Southeast Asia. Many traditional and high-tech firms started to build the manufacturing base in those places. The condition causes the gap in our industry structure. In order to improve the industry level and national competitiveness of Taiwan, information service industry, which has the features both from high-tech and service industry, plays an important role during the process. Location expresses the spatial distribution and accumulative behavior of the firms. Lack of researches about the location choice behaviors of information service industry is the reason why I choose the topic. Analytic Hierarchy Process (AHP), which has the characteristic with multi-criteria, indefinite, group decision-making, qualitative, is the method what I use in this research. Analyzing the questionnaire, the sequence from high to low of the priorities of the locational choice factors is: market factors, industrial relevance factors, policy factors, environment factors and cost factors. The results what we found in the research are listed below: 1.Comparing with traditional manufacturing industry, cost factor is not as important as before for information service industry. 2.Why information service industry firms think highly of industrial relevance factors and policy factors is inherited from the high-tech industry. 3.Why information service industry firms think highly of market factors is inherited from the service industry. 4.The result, which makes us surprised very much, is that information service industry does not emphasize the agglomeration effect of the firms. It maybe means that the need of building a science park may not be caused by the benefit of agglomeration.