In the present work, in order to evaluate the seriousness of environmental pollution caused by antibiotics abuse, and by industrial and agricultural pollutants, different strains of Pseudomonas aeruginosa were collected from industrial area, abandoned metal hardware factory, fishery pool, vegetable garden and fruit farm, river mud, and different origins of water bodies in southern Taiwan. The organisms were analyzed for their drug resistance against a variety of antibiotics and agricultural pesticides. They were also analyzed for endurance toward heavy metal ions including mercury, cadmium, arsenic and chromium ions. As the data indicated that, in terms of their resistance to clinical frequently used antibiotics, about 40% of the Pseudomonas aeruginosa isolates of the environment have developed resistance against Cefoperazone, about 20% showed resistance against Tobramycin, and only about 4% revealed resistance against Imipenem and Ceftazidime. As to heavy metal ion resistance, about 27% of the environmental Pseudomonas aeruginosa strains demonstrated resistance against mercury ion, and about 10% exhibited resistance against arsenic ions, whereas no resistance was observed toward chromium ions. In terms of resistance to agricultural pesticides, about 36% environmental isolates demonstrated resistance against Paraquat, but none of the tested Pseudomonas aeruginosa show resistance toward Cartap and Methomyl. To sum up the findings, so far only minor portion of Pseudomonas aeruginosa acquired drug resistance, therefore, immediate measure is required to prevent the spreading of drug-resistant Pseudomonas aeruginosa . It is suggested that all the physicians and pharmacists to prescribe antibiotics should be more careful and responsible manner. Meanwhile, it would also call on the restrained usage of pesticides and antibiotics in the livestock and aquatic product industry, and strengthening pollution control in the industrial sector.