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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Participação da enzima aldeído desidrogenase 2 na insuficiência cardíaca induzida por infarto do miocárdio. / Role of aldehyde dehydrogenase 2 in myocardial infarction-induced heart failure.

Gomes, Katia Maria Sampaio 08 April 2014 (has links)
A formação de aldeídos decorrente do estresse oxidativo é cardiotóxica e contribui para o aparecimento das doenças cardiovasculares. O aldeído 4-hidroxi-2-nonenal (4HNE) apresenta grande poder nocivo cardíaco. A enzima mitocondrial aldeído desidrogenase 2 (ALDH2) é a principal responsável pela remoção do 4HNE, sendo que a ativação farmacológica da ALDH2 previne danos cardíacos oriundos do processo de isquemia/reperfusão. Com o intuito de compreender o papel desta enzima na insuficiência cardíaca (IC) tivemos como objetivos: caracterizar o curso temporal de ativação da ALDH2 pós-infarto do miocárdio em ratos e estudar o efeito da ativação farmacológica sustentada da ALDH2 na IC. Nossos resultados apontam que na 1ª, 2ª e 4ª semanas pós-infarto a atividade da ALDH2 apresenta-se reduzida. Essa redução está associada à disfunção mitocondrial e cardíaca. Contudo, o tratamento com Alda-1 proporciona uma melhora dessas funções. Assim, concluímos que a ativação seletiva da ALDH2 reduz danos cardíacos, podendo ser considerada um novo alvo terapêutico no tratamento da IC. / Here we determined the benefits of chronic activation of ALDH2 on the progression of heart failure after the onset of symptoms using a post-myocardial infarction model. We showed that a six-week treatment of myocardial infarction-induced heart failure rats with Alda-1, a selective ALDH2 activator, enhanced contractile function, improved left ventricular compliance and increased diastolic dysfunction under basal conditions and after sudden pressure-overload stress. Moreover, sustained Alda-1 treatment showed no toxicity and promoted a cardiac anti-remodeling effect by suppressing myocardial hypertrophy and fibrosis. Moreover, ALDH2 activation-mediated cardioprotection was associated with improved mitochondrial function. Further Alda-1 treatment preserved mitochondrial function in vitro upon 4-HNE addition. Therefore, selective activation of mitochondrial ALDH2 reduces aldehydic load, preserves mitochondrial function and improves heart failure outcome, suggesting that ALDH2 activators have a potential therapeutic value for treating heart failure patients.
2

Participação da enzima aldeído desidrogenase 2 na insuficiência cardíaca induzida por infarto do miocárdio. / Role of aldehyde dehydrogenase 2 in myocardial infarction-induced heart failure.

Katia Maria Sampaio Gomes 08 April 2014 (has links)
A formação de aldeídos decorrente do estresse oxidativo é cardiotóxica e contribui para o aparecimento das doenças cardiovasculares. O aldeído 4-hidroxi-2-nonenal (4HNE) apresenta grande poder nocivo cardíaco. A enzima mitocondrial aldeído desidrogenase 2 (ALDH2) é a principal responsável pela remoção do 4HNE, sendo que a ativação farmacológica da ALDH2 previne danos cardíacos oriundos do processo de isquemia/reperfusão. Com o intuito de compreender o papel desta enzima na insuficiência cardíaca (IC) tivemos como objetivos: caracterizar o curso temporal de ativação da ALDH2 pós-infarto do miocárdio em ratos e estudar o efeito da ativação farmacológica sustentada da ALDH2 na IC. Nossos resultados apontam que na 1ª, 2ª e 4ª semanas pós-infarto a atividade da ALDH2 apresenta-se reduzida. Essa redução está associada à disfunção mitocondrial e cardíaca. Contudo, o tratamento com Alda-1 proporciona uma melhora dessas funções. Assim, concluímos que a ativação seletiva da ALDH2 reduz danos cardíacos, podendo ser considerada um novo alvo terapêutico no tratamento da IC. / Here we determined the benefits of chronic activation of ALDH2 on the progression of heart failure after the onset of symptoms using a post-myocardial infarction model. We showed that a six-week treatment of myocardial infarction-induced heart failure rats with Alda-1, a selective ALDH2 activator, enhanced contractile function, improved left ventricular compliance and increased diastolic dysfunction under basal conditions and after sudden pressure-overload stress. Moreover, sustained Alda-1 treatment showed no toxicity and promoted a cardiac anti-remodeling effect by suppressing myocardial hypertrophy and fibrosis. Moreover, ALDH2 activation-mediated cardioprotection was associated with improved mitochondrial function. Further Alda-1 treatment preserved mitochondrial function in vitro upon 4-HNE addition. Therefore, selective activation of mitochondrial ALDH2 reduces aldehydic load, preserves mitochondrial function and improves heart failure outcome, suggesting that ALDH2 activators have a potential therapeutic value for treating heart failure patients.
3

Papel da mutação ALDH2*2 na insuficiência cardíaca: potencial terapêutico da Alda-1. / Role of ALDH2*2 mutation in heart failure: therapeutic potencial of Alda-1.

Lima, Vanessa Morais 18 October 2016 (has links)
A enzima aldeído desidrogenase 2 (ALDH2), localizada na matriz mitocondrial, é crucial na manutenção do balanço intracelular de aldeídos. Atualmente, estima-se que 8% da população mundial apresentam uma mutação pontual no gene da ALDH2 (E487K, ALDH2*2) que confere perda de até 95% na atividade enzimática. No presente projeto utilizamos camundongos knock-in ALDH2*2 para avaliar o impacto da mutação ALDH2 (E487K) na disfunção cardíaca induzida pelo infarto do miocárdio. Observamos que os animais mutantes possuem a atividade da ALDH2 reduzida e desenvolvem disfunção cardíaca e remodelamento ventricular semelhante aos animais selvagens após infarto do miocárdio. Porém, os animais com a mutação E487K possuem uma significante redução no consumo de oxigênio basal (respirometria), máximo (teste físico até a exaustão) e em mitocôndria cardíaca isolada, quando comparados aos animais selvagens. Por fim, o tratamento sustentado com Alda-1 (ativador da ALDH2) foi efetivo em restaurar a função cardíaca dos animais infartados, independente do genótipo. / Aldehyde dehydrogenase 2 (ALDH2), located in the mitochondrial matrix, is critical for the maintenance of cellular redox balance by removing reactive aldehydes produced during oxidative stress. It is estimated that 8% of the world population have a point mutation in the ALDH2 gene (E487K), which reduces its enzymatic activity by 95%. Here, we study the impact of the E487K variant of ALDH2 on myocardial infarction-induced heart failure, using ALDH2 E487K knock-in mice. We observed that mice carrying the ALDH2 variant have reduced ALDH2 activity and protein levels compared to WT mice. Despite of reduced oxidative metabolism, animals with ALDH2 mutation develop cardiac dysfunction and ventricular remodeling equivalent to WT animals after myocardial infarction. Finally, sustained Alda-1 treatment (ALDH2 activator) during 6 weeks improved cardiac function of infarcted animals, regardless of genotype.
4

Participação da enzima aldeído desidrogenase 2 na progressão da doença arterial periférica. / Role of aldehyde dehydrogenase 2 during peripheral arterial disease progression.

Ribeiro, Márcio Augusto Campos 21 September 2017 (has links)
A doença arterial periférica (DAP) é uma síndrome degenerativa multifatorial que acomete principalmente idosos e tem como principais características a redução da qualidade de vida e o aumento da mortalidade cardiovascular. Dentre as limitações funcionais impostas pela doença, a mais evidente é a piora da capacidade locomotora decorrente da claudicação intermitente (períodos alternados de isquemia e reperfusão). Atualmente não existem tratamentos farmacológicos capazes de bloquear a progressão da DAP, caracterizada pela redução da capacidade oxidativa muscular, excessivo estresse oxidativo e consequente acúmulo de aldeídos reativos no leito afetado. Com base nisso, o presente trabalho visou caracterizar o papel da enzima aldeído desidrogenase 2 na progressão da DAP. Para isso caracterizamos o modelo animal de DAP, e verificamos que camundongos C57Bl/6 após a cirurgia de oclusão de fluxo apresentam redução da atividade catalítica da enzima ALDH2. Fato acompanhado por uma intolerância ao esforço físico, atrofia e prejuízo na contratilidade muscular, além de desarranjo sarcomérico e mitocondrial. Em modelo de cultura celular, a inativação da enzima ALDH2, após hipóxia e reoxigenação levou à prejuízo na angiogênese e disfunção mitocondrial. Mesmo fenômeno observado nos animais DAP tratados com inibidor, que desenvolveram disfunção mitocondrial e pobre resposta à atividade física. Em modelo de genético de redução da atividade da enzima ALDH2, foi possível ver exacerbada disfunção muscular. Baseado nesses resultados, acreditamos que a enzima ALDH2 desempenha um importante papel na progressão da doença arterial periférica, sendo um possível alvo terapêutico. / Peripheral arterial disease (PAD) is a multifactorial disease which mainly affects elderly reducing quality of life and increasing cardiovascular mortality. Among the functional limitations imposed by the disease, the progressive worsening of locomotor capacity arising from intermittent periods of ischemia and reperfusion, are related to reduced muscle oxidative capacity, excessive oxidative stress and consequent accumulation of reactive aldehydes in the affected leg. We recently demonstrated that lipid peroxidation induced-toxic aldehydes accumulation contributes to ischemic heart disease progression. Interestingly, oxidation of these aldehydes through aldehyde dehydrogenase 2 (ALDH2) activation is cardioprotective. Based on that, this work characterizes the role of ALDH2 during PAD progression. The PAD animal model presents decreased skeletal muscle ALDH2 enzyme activity associated with exercise intolerance, muscle atrophy, poor muscle contraction, skeletal muscle sarcomeric disruption and giant mitochondrial accumulation. After ALDH2 inhibitor treatment, cell culture submitted to hypoxia/reoxygenation stress showed no angiogenesis and mitochondrial dysfunction. Similar data was seen at animal model, where PAD mice treated with ALDH2 inhibitor shows mitochondrial dysfunction, greater atrophy and affected physical exercise response. Also, transgenic mice for ALDH2 (which has a reduced ALDH2 activity) submitted to PAD showed a smaller muscle contraction, compared to wild type PAD mice. Our data points to ALDH2 as an important therapeutic target to develop new therapy strategies to counteract PAD progression.
5

Mecanismos de Cardiotoxicidade da Doxorrubicina em Ratos Wistar e Potencial Cardioprotetor da Alda-1

Souza, Leonardo da Cunha Menezes January 2019 (has links)
Orientador: Daisy Maria Fávero Salvadori / Resumo: A cardiotoxicidade induzida pela doxorrubicina (DOX), antraciclina isolada da actinobacteria Streptomyces peucetius e amplamente utilizada na terapia antineoplásica, corresponde a um dos mais importantes eventos patofisiológicos que limitam sua aplicação clínica. No entanto, não são completamente conhecidos todos os mecanismos envolvidos nessa toxicidade, o que diminui as possiblidades de intervenção e a redução dos efeitos colaterais para os pacientes sob tratamento. Uma das hipósteses é que os aldeídos gerados pela ação da DOX atuam sobre membranas mitocondriais, alterando o estado redox e formando adutos com proteínas, os quais prejudicam o correto funcionamento da organela. Atividades deletérias da DOX sobre outros componentes celulares, como, por exemplo, os ácidos ribonucleicos, são, também, possíveis mecanismos de toxicidade do antineoplásico. Várias estratégias têm sido utilizadas para minimizar os efeitos adversos da DOX. Uma delas, é a busca por compostos que possam proteger as células da ação citotóxica. Nesse sentido, a Alda-1, pertencente ao grupo das chaperonas e agonista da enzima aldeído desidrogenase mitocondrial (ALDH2), vem sendo testada com o objetivo de reduzir os efeitos adversos dos metabólitos e radicais gerados pelo antineoplásico. Para investigar outros possíveis mecanismos de ação da DOX e o efeito cardiprotetor da Alda-1, este estudo foi delineado utilizando duas abordagens distintas: experimentos in vivo, com ratos Wistar machos submetidos a trata... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The cardiotoxicity induced by doxorubicin (DOX), anthracycline isolated from the actinobacteria Streptomyces peucetius, and widely used as an antineoplastic drug, is one of the most important pathophysiological events that limit its clinical application. However, all the mechanisms involved in this toxicity are not fully understood. One hypothesis is that the aldehydes generated by DOX act on mitochondrial membranes, modifying the redox state and proting adducts with proteins. DOX activities on other cellular components, such as ribonucleic acids, are also possible mechanisms of toxicity. Several strategies have been used to reduce the DOX adverse effects. One of them is the identification of compounds that can protect cells against cytotoxic. Alda-1, which belongs to a group of chaperones and is an agonist of the mitochondrial aldehyde dehydrogenase (ALDH2), has been tested to reduce the adverse effects of metabolites and radicals generated by DOX. To investigate other possible DOX mechanisms of action, and the cardioprotective activity of Alda-1, this study was designed using two different approaches: in vivo, with male Wistar rats submitted to acute and chronic treatments; and, in vitro, in mice fibroblasts and cybrids with ND5 (gene that encodes the mitochondrial Complex I subunit) mitochondrial gene heteroplasmy. The expression profiling of genes related to beta oxidation pathways, Bax, Bcl-2, C1QBP, ALDH2 and miR34a microRNA (ALDH2 expression regulator), and the lipoper... (Complete abstract click electronic access below) / Doutor
6

Assessment Of Dewatering Requirements For Caldag Nickel Mine In Western Turkey

Cankara, Cigdem 01 October 2011 (has links) (PDF)
The purpose of this study is to assess the dewatering requirements of planned open pit nickel mining at &Ccedil / aldag Site in Western Turkey. Dewatering is required for safe and efficient working conditions and pit wall stability. With this scope, a groundwater model of the study area is developed and used to predict the dewatering rate. The methodology mainly involves data collection, site hydrogeologic characterization and development of conceptual model, followed by construction and use of a groundwater model to predict the dewatering requirements of the mine site. The groundwater flow modeling is carried out using MODFLOW software and the dewatering simulations are carried out using MODFLOW Drain package. The drain cell configuration is determined by pit boundaries and invert elevations of drains corresponded to the bench elevations that will be achieved with respect to the mining schedule. In the transient model runs, monthly time steps were used. Using the outflow from in-pit drain cells, the v monthly dewatering rates are calculated. In order to assess the impacts of the hydraulic conductivity of the laterite on the pit inflow rates, simulations were carried out for different values of hydraulic conductivity of laterites. The predicted flow rate using the calibrated model is 107.54 L/s. A tenfold reduction in the hydraulic conductivity of laterite resulted in three fourths of decrease in the flow rate (24.42 L/s). Consequently, a wide range of flow rates for different hydraulic conductivity values of laterite was calculated. In order to confirm the hydraulic conductivity of laterites in the area, and to obtain a realistic dewatering rate, further pumping tests are needed.
7

Pressure Leaching Of Caldag Lateritic Nickel Ore

Onal, Mehmet Ali Recai 01 February 2013 (has links) (PDF)
The purpose of this study was to investigate the process optimization of combined high pressure acid leaching (HPAL) and mixed hydroxide precipitation (MHP) route for the extraction of nickel and cobalt from &Ccedil / aldag lateritic nickel ore. In order to extract nickel and cobalt values into pregnant leach solution (PLS), several process parameters of HPAL including acid load, temperature, leaching duration and particle size were investigated in comparative manner at constant solid concentration and agitation speed. After HPAL trials, it has been found that more than one combination of parameters offered higher than 90% extraction efficiencies for both nickel and cobalt. Among them, 0.325 kg/kg acid load, 250&deg / C, 1 hour duration and 100% -1 mm particle size was selected as the optimum conditions with 94.1% Ni and 94.0% Co extractions. A stock of PLS was prepared under the stated conditions that was treated by downstream operations in order to obtain MHP. Initially by two-stage iron removal of downstream operations major impurities iron, chromium and aluminum were nearly completely removed with acceptable nickel and cobalt losses from PLS. Then, the nickel and cobalt were precipitated by two-stage mixed hydroxide precipitation. In the first step of MHP, the optimum conditions were chosen as pH=7.10, 60&deg / C and 1 hour duration. The intermediate product obtained at these conditions contained 44.3% Ni, 3.01% Co with 3.06% Mn contamination. In summary, it was found that &Ccedil / aldag nickel laterite ore was readily leachable under HPAL conditions and PLS obtained was easily treatable in order to produce saleable MHP.
8

La poésie féminine italienne des années soixante-dix à nos jours. Parcours d'analyse textuelle / Italien women poetry from the seventies to nowadays. Itineraries of textual analysis / La poesia femminile italiana dagli anni Settanta a oggi. Percorsi di analisi testuale

Zorat, Ambra 05 December 2009 (has links)
À partir des années soixante-dix les femmes poètes s'affirment avec énergie dans le panorama littéraire italien. Bien que leur présence dans les anthologies les plus reconnues soit encore assez réduite, leurs écritures poétiques se caractérisent par une puissante originalité. L'objectif de cette thèse est d'étudier ces productions poétiques tout en s'interrogeant sur la possibilité d'identifier des éléments communs. Il ne s'agit pas de définir une spécificité féminine dans une perspective essentialiste, mais d'interpréter certaines données textuelles en se référant à un contexte historique et culturel bien défini. Le corpus de travail comprends les œuvres des femmes poètes suivantes: Amelia Rosselli (1930-1996), Alda Merini (1931), Jolanda Insana (1937), Patrizia Cavalli (1947) et Patrizia Valduga (1953). Afin de respecter les singularités de chaque écriture poétique et d’éviter des simplifications réductrices, nous avons accordé la priorité à l'analyse textuelle et organisé les chapitres selon une approche monographique plutôt que thématique. L'analyse révèle que ces femmes poètes abordent avec obstination trois nœuds problématiques: elles développent une réflexion sur la valeur de la langue poétique, ont tendance à structurer leur poésie autour d'oppositions fortes et irréductibles, et, enfin, font souvent appel à des éléments de type théâtral. Ces caractéristiques sont interprétées en considérant le rapport ambigu et contradictoire que le sujet féminin entretient avec le code poétique: il ressent un fort besoin d'inscription dans la langue poétique, mais aussi un sens d'extranéité. Cette tradition qui lui est chère ne lui appartient pas complètement car il a été exclu de son élaboration. / As from the seventies women poets assert themselves with energy in the Italian literary survey. Even if their presence in the most famous anthologies is curtailed, their poetic writings are characterized by a powerful originality. The aim of this thesis is to study their poetic production inquiring into the possibility of common elements. It’s not about defining a female specificity from an essentialist point of view, the purpose is rather to interpret some textual data with reference to a well-defined historical and cultural context. The study corpus includes works of the following Italian woman poets: Amelia Rosselli (1930-1996), Alda Merini (1931), Jolanda Insana (1937), Patrizia Cavalli (1947) and Patrizia Valduga (1953). In order to respect the particularities of every writing and to avoid hasty and restrictive simplifications, a great importance has been conferred to the textual analysis and the chapters have been arranged according to a monographic approach rather than a thematic structure. The result of the research demonstrates that contemporary Italian women poets attend insistently three knotty problems: they develop a reflection about the power of poetic language, they display a tendency to structure their verse on strong oppositions without appeasing synthesis and they often resort to dramatic elements. These characteristics can be interpreted referring to the double and conflicting position of the female subject towards poetic code: this new subject needs to inscribe himself in the poetic language, but he also feels a sense of extraneousness. The tradition he loves doesn’t belong completely to him as he was left out of its elaboration.
9

A literatura santomense e a resistência feminina por Alda Espírito Santo e Conceição Lima

Gonçalves, Paulo Sergio January 2018 (has links)
Esta dissertação tem como objetivo analisar a resistência feminina a partir da produção poética de Alda Espírito Santo, poetisa do arquipélago africano de São Tomé e Príncipe. Para tal, traz a contextualização histórica e a análise de poemas selecionados da obra É Nosso o Solo Sagrado da Terra – poesia de Protesto e Luta, onde a poetisa pontua as questões históricas de seu povo, despertando-o à necessidade do livramento do jugo colonial. Ou seja, a representação feminina usada por Alda Espírito Santo em seu sujeito poético, traz como característica a resistência e a convocação do povo africano. Também é estudado o legado deixado por ela na poesia contemporânea, aqui representada por Conceição Lima, quando são analisados poemas de suas obras O útero da casa, A dolorosa raiz do Micondó e O País de Akendenguê. A fundamentação teórica está baseada nos estudos de Inocência Mata, Gaston Bachelard, Maurice Hallbwachs e Paul Ricouer. Nos diferentes poemas onde se encontra a representação feminina, é possível encontrar o uso da memória e do espaço natal do sujeito poético, que trazem, além do intimismo, o compromisso político e social com seu povo. Alda Espírito Santo e depois Conceição Lima assumem o papel de porta-voz do povo santomense e carregam, em suas poesias, o compromisso de, mesmo em épocas diferentes, estarem na linha de frente, quando alertam o povo e acordam as “consciências adormecidas” do povo santomense. O trabalho, portanto, traz em suas análises e em sua contextualização histórica, uma pesquisa que demonstra a importância do papel da Literatura como instrumento de conscientização política e social em São Tomé e Príncipe. Traz também, por meio da observância do legado seguido por Conceição Lima, o sentimento de sentinela vigilante que sua poesia propõe, mantendo, até os dias atuais, a resistência feminina no arquipélago africano e em toda África. / This dissertation aims to analyze female resistance from the poetic production of Alda Espírito Santo, a poet from the African archipelago of São Tomé and Príncipe. In order to do this, a historical contextualization and analysis of selected poems of the work É Nosso o Solo Sagrado da Terra – poesia de Protesto e Luta, in which the poet highlights the historical questions of her people in an attempt to awaken them to the need for liberation of the colonial rule are presented. That is, the feminine representation used by Alda Espírito Santo in her poetic subject, brings as a characteristic the resistance and the convocation of the African people. The study also includes her legacy to contemporary poetry, represented in this dissertation by Conceição Lima with the analysis of poems from O útero da casa, A dolorosa raiz do Micondó and O País de Akendenguê. The theoretical framework is based on the studies of Inocência Mata, Gaston Bachelard, Maurice Hallbwachs and Paul Ricouer. In the various poems in which the female representation is found, it is possible to find the use of memory and hometown of the poetic subject, which brings in addition to intimacy, the political and social commitment to its people. Alda Espírito Santo and later Conceição Lima assume the role of spokepeople for the people of São Tomé and carry in their poetry the commitment that, even at different times, they are on the front line when they alert the people and waken the "sleeping consciences" of the people of São Tomé. Therefore, the study presents in its analysis and historical contextualization, a research that demonstrates the impoance of the role of Literature as an instrument of political and social awareness in São Tomé and Príncipe. Through the observance of the legacy followed by Conceição Lima, she also brings the feeling of vigilant sentinel that her poetry proposes, maintaining until now, the feminine resistance in the African archipelago and throughout Africa.
10

A literatura santomense e a resistência feminina por Alda Espírito Santo e Conceição Lima

Gonçalves, Paulo Sergio January 2018 (has links)
Esta dissertação tem como objetivo analisar a resistência feminina a partir da produção poética de Alda Espírito Santo, poetisa do arquipélago africano de São Tomé e Príncipe. Para tal, traz a contextualização histórica e a análise de poemas selecionados da obra É Nosso o Solo Sagrado da Terra – poesia de Protesto e Luta, onde a poetisa pontua as questões históricas de seu povo, despertando-o à necessidade do livramento do jugo colonial. Ou seja, a representação feminina usada por Alda Espírito Santo em seu sujeito poético, traz como característica a resistência e a convocação do povo africano. Também é estudado o legado deixado por ela na poesia contemporânea, aqui representada por Conceição Lima, quando são analisados poemas de suas obras O útero da casa, A dolorosa raiz do Micondó e O País de Akendenguê. A fundamentação teórica está baseada nos estudos de Inocência Mata, Gaston Bachelard, Maurice Hallbwachs e Paul Ricouer. Nos diferentes poemas onde se encontra a representação feminina, é possível encontrar o uso da memória e do espaço natal do sujeito poético, que trazem, além do intimismo, o compromisso político e social com seu povo. Alda Espírito Santo e depois Conceição Lima assumem o papel de porta-voz do povo santomense e carregam, em suas poesias, o compromisso de, mesmo em épocas diferentes, estarem na linha de frente, quando alertam o povo e acordam as “consciências adormecidas” do povo santomense. O trabalho, portanto, traz em suas análises e em sua contextualização histórica, uma pesquisa que demonstra a importância do papel da Literatura como instrumento de conscientização política e social em São Tomé e Príncipe. Traz também, por meio da observância do legado seguido por Conceição Lima, o sentimento de sentinela vigilante que sua poesia propõe, mantendo, até os dias atuais, a resistência feminina no arquipélago africano e em toda África. / This dissertation aims to analyze female resistance from the poetic production of Alda Espírito Santo, a poet from the African archipelago of São Tomé and Príncipe. In order to do this, a historical contextualization and analysis of selected poems of the work É Nosso o Solo Sagrado da Terra – poesia de Protesto e Luta, in which the poet highlights the historical questions of her people in an attempt to awaken them to the need for liberation of the colonial rule are presented. That is, the feminine representation used by Alda Espírito Santo in her poetic subject, brings as a characteristic the resistance and the convocation of the African people. The study also includes her legacy to contemporary poetry, represented in this dissertation by Conceição Lima with the analysis of poems from O útero da casa, A dolorosa raiz do Micondó and O País de Akendenguê. The theoretical framework is based on the studies of Inocência Mata, Gaston Bachelard, Maurice Hallbwachs and Paul Ricouer. In the various poems in which the female representation is found, it is possible to find the use of memory and hometown of the poetic subject, which brings in addition to intimacy, the political and social commitment to its people. Alda Espírito Santo and later Conceição Lima assume the role of spokepeople for the people of São Tomé and carry in their poetry the commitment that, even at different times, they are on the front line when they alert the people and waken the "sleeping consciences" of the people of São Tomé. Therefore, the study presents in its analysis and historical contextualization, a research that demonstrates the impoance of the role of Literature as an instrument of political and social awareness in São Tomé and Príncipe. Through the observance of the legacy followed by Conceição Lima, she also brings the feeling of vigilant sentinel that her poetry proposes, maintaining until now, the feminine resistance in the African archipelago and throughout Africa.

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