This thesis proposes novel methods for identification and control of multivariable systems including multiple delays and describes their application to control of general anesthesia administration. First, an identification method for multivariable systems whose input and output paths have different time delays is presented. Second, a state predictor for multivariable systems whose input and output paths have different time delays is proposed. Third, the state predictor is used for constructing a state-predictive servo control system for controlled processes whose output paths have different time delays. A robust stability analysis method of the state-predictive servo control system is also examined. Furthermore, based on results of these theoretical studies, control systems for use in general anesthesia administration are developed. First, an identification method for multivariable systems whose input and output paths have different time delays is proposed. This method comprises two steps. In the first step, the delay lengths are estimated from the impulse response matrix identified from input and output (I/O) sequences using a subspace identification algorithm. In the second step, I/O sequences of a delay-free part are constructed from the original sequences and the delay estimates, and the system matrices of the delay-free part are identified. The proposed method is numerically stable and efficient. Moreover, it requires no complex optimization to obtain the delay estimates, nor does it require an assumption about the structure of the system matrices. Second, a state predictor is proposed for multivariable systems whose input and output paths have different time delays. The predictor consists of a full-order observer and a prediction mechanism. The former estimates a vector consisting of past states from the output. The latter predicts the current state from the estimated vector. The prediction error converges to zero at an arbitrary rate, which can be determined using pole assignment method, etc. In the proposed predictor, the interval length of the finite interval integration fed to the observer is shorter than that of an existing delay-compensating observer. Consequently, the proposed predictor is more numerically accurate than the delay-compensating observer. Using the proposed state predictor, a design method of a state-predictive servo controller is described for multivariable systems whose output paths have different time delays. Furthermore, a sufficient stability condition of the state-predictive servo control system against parameter mismatches is derived. Using a characteristic equation of the perturbed closed-loop system, a stability margin can be given on a plane whose axes correspond to the magnitudes of the mismatches on system matrices and on delay lengths. In the remainder of this thesis, development of anesthesia control systems is described to illustrate an application of the theoretical results described above. First, a hypnosis control system is presented. This system administers an intravenous hypnotic drug to regulate an electroencephalogram-derived index reflecting the patient’s hypnosis. The system comprises three functions: i) a model predictive controller that can take into account effects of time delay adequately, ii) an estimation function of individual parameters, and iii) a risk-control function for preventing undesirable states such as drug over-infusion or intra-operative arousal. Results of 79 clinical trials show that the system can reduce the total amount of drug infusion and maintain hypnosis more accurately than an anesthesiologist’s manual adjustment. Second, a simultaneous control system of hypnosis and muscle relaxation is described. For development of this system, a multivariable model of hypnosis and muscle relaxation is identified using the method proposed in this thesis. Then a state-predictive servo control system is designed for controlling hypnosis and muscle relaxation. Finally, the control system’s performance is evaluated through simulation. The resultant simultaneous control system satisfies the performance specifications of settling time, disturbance rejection ability, and a robust stability range. Although this system is not fully developed, the procedure of constructing this control system demonstrates the effectiveness of the proposed methods: the identification method for systems whose input and output paths have different time delays and the design and stability analysis methods of the state-predictive servo control system. / Kyoto University (京都大学) / 0048 / 新制・課程博士 / 博士(工学) / 甲第13820号 / 工博第2924号 / 新制||工||1432(附属図書館) / 26036 / UT51-2008-C736 / 京都大学大学院工学研究科電気工学専攻 / (主査)教授 小林 哲生, 教授 萩原 朋道, 准教授 古谷 栄光 / 学位規則第4条第1項該当