Glyphosate-resistant (GR) horseweed has become a major problem in many row crop production systems in the United States. Horseweed is a winter annual weed common in no-till production systems. Fall-applied herbicides were compared with spring-applied treatments for the control of horseweed. In cotton, fall-applied trifloxysulfuron provided similar or greater control of horseweed when compared to spring-applied treatments of glyphosate + dicamba. Cotton yields with fall-applied trifloxysulfuron, clomazone, and flumioxazin were comparable to or better than spring-applied glyphosate + dicamba both years. Fall-applied cloransulam-methyl, flumetsulam, sulfentrazone, and the combination of chlorimuron-ethyl + metribuzin resulted in horseweed control and soybean yields comparable to spring-applied glyphosate + 2,4-D both years. Multiple-resistance to glyphosate and paraquat exists in a horseweed population from Mississippi. Herbicide rates of 0.066 kg ae/ha glyphosate and 0.078 kg ai/ha paraquat were required to reduce susceptible horseweed biomass 50%; whereas, rates of 0.78 kg/ha glyphosate and 0.67 kg/ha paraquat were required to reduce biomass of resistant horseweed to a similar intent. This is the first broadleaf weed species reported as exhibiting multiple-resistance to glyphosate and paraquat. The addition of metribuzin to paraquat improved control of paraquat-resistant horseweed. Paraquat at 0.84 kg/ha plus all rates of metribuzin controlled 15-cm tall horseweed at least 90% both years compared to 73% with 0.84 kg/ha paraquat alone. The addition of 1 and 2% methylated seed oil (MSO) to saflufenacil controlled horseweed 91 and 93%, respectively compared to 78% control with saflufenacil alone. The addition of saflufenacil to glyphosate improved control of GR horseweed from 50% to 100% at 21 d after treatment; control of horseweed with the combination of saflufenacil + glyphosate was additive. Saflufenacil did not affect absorption of glyphosate in glyphosate-susceptible horseweed; however, absorption increased in GR horseweed from 36 to 44% at 48 h after treatment with the addition of saflufenacil when compared to glyphosate alone treatments. Overall, the addition of saflufenacil reduced glyphosate translocation in horseweed at least 6%; however, due to the exceptional efficacy of saflufenacil on horseweed these reductions did not reduce control of GR horseweed.