21 |
Studies of resistance to Beta-lactam antibiotics in Bacillus licheniformisFrampton, Helen Kathleen January 1987 (has links)
No description available.
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22 |
A comparison of antibacterial synergism with bacterial uptake using sulphonamides and trimethoprimXing, James Zan January 1994 (has links)
No description available.
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23 |
Penicillin tolerance in Streptococcus sanguisJames, Peter Alan January 1992 (has links)
No description available.
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24 |
Antimicrobial properties of silicone quaternary ammonium compoundsParr, J. A. January 1986 (has links)
No description available.
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25 |
Cloning and characterization of Salmonella typhimurium dehydroquinate synthaseGunel Ozcan, Aysen January 1997 (has links)
No description available.
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26 |
Effect of chlorohexidine on bacterial sporesShaker, L. A. January 1988 (has links)
No description available.
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27 |
Analytical and antimicrobial studies of taurolidineJones, David Simon January 1988 (has links)
No description available.
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28 |
Studies towards the total synthesis of anticapsinBellemain, Chantal Marie-Claude January 1993 (has links)
No description available.
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29 |
In vitro antimicrobial properties of a mouthrinse containing glycerine, potassium nitrate and sodium fluorideNdlovu, Nozizwe 07 April 2008 (has links)
ABSTRACT
Introduction: Patients who have received radiation therapy due to oral cancers often
present with complications such as salivary dysfunction, mucositis, soft tissue
necrosis, infections and dental caries. The aim of this study was to investigate the
antimicrobial properties of an experimental mouthrinse which also contains analgesic
and anticaries compounds and can be used in the management of patients with oral
cancers after radiation therapy.
Methods: The experimental mouthrinse contained a mixture of 30% glycerine
(antimicrobial agent), 7% potassium nitrate (analgesic) and 0.025% sodium fluoride
(anticaries agent). The minimal inhibitory concentration (MIC) of these ingredients
was tested against Candida albicans, Staphylococcus aureus and Streptococcus
mutans over 24 hours at different concentrations. MICs of commercially available
mouthrinses containing chlorhexidine digluconate (Corsodyl®) and fluoride with
triclosan (Plax®) were also determined using the same organisms. All mouthrinses
were then tested to determine the percentage kill over 1, 2, and 3 minutes. The costs
of these mouthrinses were also compared.
Results: The MICs for glycerine were 10%, 25% and 10% for C. albicans, S. aureus
and S. mutans respectively. Potassium nitrate, sodium fluoride and alum did not show
any antimicrobial effects. The MIC of Corsodyl® was <0.02 mg/ml for all the test
organisms. The MIC for Plax was 0.02 mg/ml, <0.002 mg/ml and 0.005 mg/ml for C.
albicans, S. aureus and S. mutans respectively. Combining glycerine, potassium
nitrate and sodium fluoride into a mixture did not affect the antimicrobial properties
of these constituents. The mixture killed 99.78%, 99.88% and 99.98% of C. albicans,
61.74%, 70.64% and 85.09% of S. aureus and 91.72%, 99.47% and 99.99% of S.
mutans after 1, 2 and 3 minutes respectively. Two percent chlorhexidine digluconate
killed 98.98%, 99.97% and 99.99% of C. albicans, 95.83%, 99.68% and 99.97% of S.
aureus and 99.98%, 99.96% and 99.99% of S. mutans after 1, 2 and 3 minutes
respectively. Plax® killed 99.99% of C. albicans in one minute, 99.66%, 99.99% of S.
aureus in 1 and 2 minutes respectively; and 99.89%, 99.96% and 99.99% of S. mutans
in 1, 2 and 3 minutes respectively. The costs of similar amounts of the experimental
mouthrinse, Corsodyl® and Plax® were R5.24, R30.00 and R10.00 respectively.
Conclusion: A mouthrinse effective in relieving oral symptoms in patients receiving
radiation therapy needs to show some antimicrobial activity against in particular, C.
albicans and S. mutans, whilst at the same time having a palliative effect. This study
has shown that the experimental mouthrinse will fulfil these requirements. The
experimental mouthrinse was found to be the cheapest in comparison to Corsodyl®
and Plax®.
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30 |
The phytochemistry and microbial activity of selected indigenous Helichrysum speciesReddy, Dakshina 10 June 2008 (has links)
ABSTRACT
Helichrysum (Asteraceae) is a large genus consisting of approximately 500 species of which
245 taxa are indigenous to southern Africa. Many Helichrysum species are widely used by the
indigenous population to treat various ailments, including coughs, colds, fever, infections,
headache, menstrual pain and as a treatment for wounds.
Medicinal uses are often not species-specific but often depend on the local availability.
Guided by the traditional use and the lack of scientific information, nine species of
Helichrysum were selected for this study. The essential oils were obtained through
hydrodistillation and methanol and acetone extracts of the plant material were prepared.
The essential oil composition was determined using GC-MS. The oil profiles were mostly
dominated by the presence of monoterpenes such as a-pinene, 1,8-cineole and p-cymene.
Monoterpenes were largely absent in the essential oil of H. felinum, but this oil was rich in
sesquiterpenes with high yields of b-caryophyllene.
The antimicrobial activity of the essential oils and plant extracts were of interest due to their
traditional use as an antiseptic. The antimicrobial activity of the essential oils and extracts was
determined by disc diffusion assays and, following this, the most active species were further
investigated using the minimum inhibition concentration (MIC) assay.
Helichrysum dasyanthum displayed the best activity against B. cereus (MIC = 16 mg/ml) and
was the only extract that exhibited activity against all three fungal strains tested (C.
neoformans, 1 mm; C. albicans, 3 mm; and A. alternata, 2 mm). The essential oil of H.
petiolare and H. felinum exhibited the most pronounced activity against the fungal strains in
the disc diffusion assay (C. albicans, 2mm).
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