Global ETD Search

21	Analysis of the molecular regulation of cell proliferation and cell death Harrington, Elizabeth Anne January 1995 (has links) No description available. 572.8 Apoptosis
22	Study of the chromatin binding properties of the high mobility group 1 protein (HMGB1) in living and dead cells Scaffidi, Paola January 2002 (has links) No description available. 572 Apoptosis
23	Role of nitric oxide in the regulation of tumor necrosis factor alpha signalling Barsacchi, Rico January 2003 (has links) No description available. 616 Apoptosis
24	Investigation of the apoptotic role of CD95-L in immune privilege Barcia, Rita N. January 2003 (has links) No description available. 571 Apoptosis
25	Tissue transglutaminase & tumour progression : cell death & extracellular matrix stabilisation Parry, James January 2002 (has links) No description available. 616 Apoptosis
26	The immunomodulatory mechanisms of extracorporeal photopheresis Bladon, John January 2003 (has links) No description available. 616 Apoptosis
27	Structural and functional characteristics of novel mRNA isoforms of the death-promoting gene bax Thomas, Anne L. January 1998 (has links) No description available. 572.8 Apoptosis
28	Role of IGF-I signalling pathways in rat mesangial cell survival Ditchfield, Claire Marie January 2001 (has links) No description available. 612 Apoptosis
29	Effects of Cellular Apoptosis on Productivity of a Mammalian Cell Culture Process Cote, Shelly A. 06 April 2006 (has links) Apoptosis, programmed cell death, is a hot topic in recent research due to the potential applications to various areas by regulating its pathway. In industrial large scale animal cell culture processes, research on how to regulate or predict the apoptotic pathway and understanding what signals the apoptotic cascade has lead to a new opportunity to enhance process robustness, improve final performance including productivity, and eventually, reduce production costs. Current industrial cell culture processes normally involve a high cell density process in a large-scale bioreactor as a suspension culture that proliferates the cells beyond their optimal growth conditions. Under these conditions, apoptosis will be triggered, and consequently, cell viability will be decreased, and the chance for product degradation by the release of intracellular proteases and glycosidases will increase. Therefore, characterizing which culture conditions will induce apoptosis during a particular cell culture process can be a valuable tool to optimize cell viability and possibly productivity. Since the conventional method for cell count and viability measurement does not differentiate the cells in early to mid-stage apoptosis from the normal cells, it would be difficult to understand the effect of early stage apoptosis. This study elucidates the correlation between the culture conditions and apoptosis during a mammalian cell culture process and its effects on the productivity using real-time apoptotic assays for accurate cellular growth and death profiles. Apoptosis induced by low pH, glucose and glutamine limitation, lactate toxicity and Camptothecin has been shown to significantly increase the yield and specific productivity most likely due to release of product during secondary necrosis at the culmination of the apoptosis pathway. productivity apoptosis
30	Germ cell apoptosis and death receptor response in the rodent testis after acute mono-(2-ethylhexyl) phthalate and cisplatin exposure Giammona, Charles John. January 2002 (has links) Thesis (Ph. D.)--University of Texas at Austin, 2002. / Vita. Includes bibliographical references. Available also from UMI Company. Apoptosis. Spermatogenesis.

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