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A population-based study of lung cancer and benign intrathoracic tumorsMäkitaro, R. (Riitta) 04 June 1999 (has links)
Abstract
A prospective population-based study was conducted to assess
the incidence, diagnosis, histology, treatment and survival of
lung cancer in northern Finland. The results were compared with
those obtained in a similar survey 20 years earlier.
In a population of 440,000, altogether 602 lung cancer patients,
510 men and 92 women, were diagnosed during the years 1990 - 92,
the annual incidence per 100,000 being 63 for males and 9.5 for
females. Lung cancer was confirmed histologically in 381 cases
(63%) and in addition, cytologically in 135 cases (23%).
Squamous cell carcinoma was the most common histologic type (40%),
the proportion of adenocarcinomas being 26%, small-cell
carcinomas 24% and large cell carcinomas 4%.
The age-standardized incidence of lung cancer had decreased significantly
among males (from 87 to 63 per 100 000) compared to the
situation 20 years earlier but increased among females (from 4.1
to 9.5), mainly due to adenocarcinoma.
The 5-year survival rate had improved during 20 years from
4% to 12% (p < 0.001).
The differences in survival between the histological types (χ2logrank = 59.2,
p < 0.0001), TNM stages (χ2logrank = 199.6,
p < 0.001), symptomatic stages (χ2logrank = 120,
p < 0.001) and treatments (χ2logrank = 277,
p < 0.001) were also significant. A
total of 20% of the patients were operated on in the newer
series of patients, the corresponding percentage in the earlier
series being 16%. The 5-year survival of the patients
who had been operated on had increased from 23% to 48%.
The survival of patients with non-small-cell lung carcinoma
had increased significantly, even though the patients were older
now than earlier.In seventy operated lung cancer patients, the
histological tumor types and grades were compared with the etiological
factors of lung carcinoma, including cigarette smoking and asbestos
exposure. A majority of the patients (93%) were smokers.
The incidence of adenocarcinoma among non-smokers had remained
the same, 50%. The accumulation of the p53 protein in
lung carcinoma was associated with heavy smoking. Exposure to asbestos
fibers either by a positive history or by a number of asbestos
bodies (AB) in the histological sections of lung tissue was also
associated with p53 accumulation.
Benign intrathoracic tumors are uncommon, and their occurrence
in unselected populations is poorly defined. Thirty-six benign
intrathoracic tumors were found. A histologic diagnosis was available
for 24 (67%). Hamartoma was the most common benign lung
tumor.
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Mortality patterns among civilian workers in Royal Navy DockyardsSullivan, Keith Richard January 1994 (has links)
No description available.
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Gamma Knife Radiosurgery of Brain Metastasis from Malignant Pleural Mesothelioma : Report of Three Cases with Autopsy Study in a CaseSHIBAMOTO, YUTA, MORI, YOSHIMASA, ASAI, MASAMI, TORIYAMA, TAKANOBU, HASHIZUME, CHISA, TSUGAWA, TAKAHIKO, KOBAYASHI, TATSUYA 02 1900 (has links)
No description available.
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