nÃo hà / A retrospective chart review of patients diagnosed as having myasthenia gravis, followed in Hospital UniversitÃrio Walter CantÃdio, Hospital Geral de Fortaleza and by neurologists in CearÃ, Brazil, from October 1981 to June 2009 was performed. Clinical and epidemiologic aspects were evaluated. In this work, 122 patients were studied, of whom 85 (69.7%) were females and 37 (30.3%) were males. The disease duration ranged from five months to 50 years (8.9  8.1 years). Age at the first symptoms varied from 0 to 74 years (31.9  14.4 years). The main first symptoms and signs were ptosis, diplopia and member weakness. Generalized myasthenia was the most common clinical presentation, but 5.1% (n=6) persisted as ocular myasthenia. Thymectomy was performed in 42.6% (n=52) of myasthenic patients. A thymoma was present in 10 patients. Serum acetylcholine receptor (AChR) antibodies were present in 80% (n=20) of specimens tested. / Foram analisados, retrospectivamente, os prontuÃrios de pacientes com diagnÃstico de miastenia grave (MG), diagnosticados e seguidos no Hospital UniversitÃrio Walter CantÃdio, Hospital Geral de Fortaleza e por neurologistas que tratavam doenÃas neuromusculares, no perÃodo de outubro de 1981 a junho de 2009 no Estado do CearÃ, Brasil. Foram coletados dados clÃnicos e epidemiolÃgicos. Foram estudados 122 pacientes, sendo 85 (69.7%) do sexo feminino e 37 (30.3%) do sexo masculino. O tempo de duraÃÃo da doenÃa variou de cinco meses a 50 anos (8.9  8.1 anos). A idade de inicio da doenÃa variou de zero a 74 anos (31.9  14.4 anos). Na amostra estudada, os primeiros sintomas foram principalmente ptose palpebral superior, diplopia e fraqueza dos membros. A maioria dos pacientes apresentou a forma generalizada, enquanto 5.1% (n= 6) persistiram com miastenia ocular. Timectomia foi realizada em 42.6% (n=52) dos pacientes. A presenÃa de timoma foi demonstrada em 10 pacientes. Anticorpos anti-receptor de acetilcolina estavam presentes em 80% (n=20) das amostras testadas.