As distance learning evolved, course designers and teachers quickly recognized the value of integrating online features into the classroom. The result was blended learning, a combination of online and face-to-face components. This complex and dynamic new form of education has raised many questions about the role of computer-mediated communication in education and has provided new opportunities for extending research in learning and communication. The purpose of the study was to determine whether a blended class will produce different (and possibly better) results in terms of student perceptions of the overall learning experience and student satisfaction than traditional lecture-based face-to-face instruction or learning that is delivered entirely online. The main goals of this study were to compare the effectiveness of face-to-face, online, and blended instruction, and to examine the role of interactions in the effectiveness of each educational method. While each form of instruction received very positive feedback from both students and instructors and the newly introduced blended courses proved very successful in terms of overall satisfaction with the learning experience, the traditional lecture-based courses produced more positive attitudes toward the subject matter. The possible causes of these discrepancies between some of the quantitative and qualitative results point toward the role of previous experience with online learning, cognitive development, and learning styles.