The dissertation deals with selected issues in the field of the calculation of the response of building structures which are excited with dynamic non-stationary displacement loading of its ground. Seismic load has been assumed. Procedures, how to work with seismic records with respect to the accuracy of dynamic calculations, how to modify the response spectrum to ensure the reliability, how to generate synthetic accelerogram requiring more accurate response, are recommended. Synthetic akcelerogram has been generated by own approaching, which has been used as the excitation function in the experimental seismic testing of autoclaved concrete brick building in model scale. Response values of motion in the measured points of the experiment were compared with the linear and nonlinear dynamic calculations by using the finite element method models. Different levels of detail of the numerical models have been used. The shear wall behaviour has been modelled by using constitutive models with brittle failure as well as using of non-linear interaction interface with possible delamination between the masonry bricks. The behaviour of the mathematical model of wall systems has been calibrated with respect to the measured data at shear wall experiments in real and model scale of walls.