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The subfornical organ (SFO) is an area in the brain characterized by lack of a blood-brain-barrier that contributes to interaction between the circulation and the central nervous system, and plays key roles in regulation of energy balance. The SFO has two subregions- the dorsolateral peripheral SFO (pSFO) and the ventromedial core of the SFO (cSFO). This study demonstrated the expression of voltage-gated Na+ channel 1.3 (Nav1.3) in the SFO neurons, and a higher Nav1.3 expression in the pSFO. Based on the Nav1.3 expression pattern, intrinsic electrophysiological properties were compared between cSFO and non-cSFO neurons (putative pSFO neurons) identified by a SmartFlare mRNA probe. The patch clamp results revealed a bursting firing pattern in cSFO neurons and a higher spontaneous neuronal activity in non-cSFO neurons. The higher neuronal activity might be related to a more depolarized resting membrane potential and a higher trend of Na+ current density.

The structure of old monumental churches differs a lot from contemporary buildings. The structural materials were wood, brick and stone. In order to construct high buildings with huge spans, thick massive walls and many massive columns were needed. Originally these buildings had no heating and for centuries the outdoor temperature determined the indoor climate. As churches are considered historical heritage buildings their renovation should be thoroughly studied.               In this thesis the transmission losses of Hamrånge church will be analysed. Hence, the transmission trough walls and windows as well as the heat buffering of materials will be examined. In addition, the effect of possible reformation measurements will be concluded.               Finally, this project belongs to a complete study of the church, were not only transmission losses are considered but also air infiltration losses and solar heat gain. That way, a comparison between them will be carried out in order to contribute to attain the objective of the project: possible restoration for church heating system with respect to preservation, energy requirements, thermal comfort and aesthetics. / Church project

The main topic of this project is to do an energy study of the Mariners’ Church, ‘Sjömanskyrkan’, placed in the Centralplan of Gävle, Sweden. This is an old building built in the late 1800’s by the evangelic-lutheran missionaries and nowadays is used to realize different cultural activities such as concerts, meetings, workshops…   Energy is one of the most important points in the actual society. The fact that common energy sources are being depleted and the use of these resources produces a lot of contaminants have brought some many international crisis and conflicts. A big use of oil fuels can influence the government behavior and condition its laws and regulations. Nowadays, the majority of the countries want to reduce their fossil energy sources dependency, e. g. Sweden designed an energy commission in 2005 to make a report on how these uses of petroleum, natural gas and ‘fossil raw materials’ can be reduced until 2020. This project wants to follow this direction, providing some energy savings through the investment and renewal of old public buildings.   The aim of this project is to know how much and in which way this building uses the energy, locating its strong and weak points, and point out some different energy efficiency measures to improve the situation.   First of all, an energy balance has been realized. In the part of the heat gains the total energy use is 274 MWh / year. On the other hand the energy losses give a quantity of 273 MWh / year. The differences between both are the losses by infiltration, 1MWh / year. Most of this energy is lost because of the transmission, about a 95% of the energy losses. The age of the building and its old materials are the main reason for this out of proportion percentage. That’s why the main efficiency measures are referred to this part.   After this first analysis, some efficiency measures have been carried out. The most important are referred to the structural elements like walls, windows, roof and floor. All of these procedures can save 45% of the energy losses. This is evidence that old buildings and this in particular, are really bad insulated and have a lot of heat leakages. Also some behavior recommendations are given, like maintenance works and lightning improvements.

The purpose of this study was to assess the reliability and validity of a new computerized method of assessing balance and gaze control under a broad range of physical and visual conditions in people with vestibular hypofunction. Test retest reliability for balance performance as measured by COP excursion was good in all conditions with ICCs ranging from .64 to .90 in the AP and ML directions. Closed loop visual tracking as measured by COD had high reliability on the sponge and treadmill (ICC=.71-.75) as compared to open loop tracking (ICC=.325-.463) which was poor. Convergent validity showed poor correlation between clinical tests and the electronic balance and gaze assessments. Construct validity demonstrated that as physical and visual loads increased, balance performance decreased significantly on the sponge as measured by an increase in COP excursion and visual tracking performance decreased significantly on the treadmill as measured by a decrease in COD.

Substantial numbers of Canadians work shifts. The reasons individuals work shifts are varied and complex. Prior research regarding the relationship between work-family balance, gender, quality of life indicators and health has yielded mixed results. The goal of this research was to examine the association between work-family balance, quality of life indicators and Canadians' overall health status while controlling for socio-economic status, education, family structure and life satisfaction. The two objectives of this study were: 1) to explore how the relationship between work-related characteristics, quality of life and overall health status is different among Canadian male and Canadian female workers, controlling for age, education, socio-economic status, family structure, and life satisfaction and, 2) to examine the relationship between shift configuration and employees' overall health status, controlling for socio-economic status, gender, education, family structure and life satisfaction. This study involved analyses of cross-secional national data from the General Social Survey (GSS) 2006, Cycle 20. The sample for the study included employed men and women who were married or living in common-law relationships, ages 18 through 69. Bivariate and logistic regression analyses were conducted to address the stated research objectives. Appropriate survey weights were applied to estimate population characteristeics. To fully account for the survey's complex sample design, mean bootstrap weights were used for variance estimation and calculation of confidence intervals. Findings indicated that for women and shift workers, both work-to-family spillover and family-to-work spillover were predictve of poor self-rated health. Spillover was not a predictor of poor health for men or day workers. Shift configuration was not found to be significantly correlated with poor self-rated health. Analyses should be repeated to test for interaction between shift work and sleep quality as sleep quality was controlled for in this study.

Physiotherapy for people with stroke has been found to be beneficial but details of the most effective interventions are unclear. Further development of the evidence base for stroke physiotherapy is limited by a lack of clinical practice models, sensitive clinically based outcome measures and effective stratification techniques to characterise homogenous groups of subjects. These issues are addressed here with regard to balance and posture. These aspects were chosen because they form a cornerstone of stroke physiotherapy as they are thought essential for the rehabilitation of functional activities. A systematic review of assessment methods in the literature revealed a lack of measurement tools which met the utility criteria: reliability, validity, sensitivity to short-term change, suitability for a wide range of abilities, ease of use and suitability for different settings. This prompted the development of a new measurement tool. Firstly, a model of the clinical assessment process was developed using an adapted focus group method with neurological physiotherapists. This informed the content of a new measurement tool which combined an ordinal scale with functional performance tests- the Brunel Balance Assessment. The tool was evaluated in a series of studies involving 92 stroke patients. It was hierarchical (coefficient of reproducibility= 0.99, coefficient of scalability = 0.69), reliable (100% agreement) and valid as a measure of balance disability (r=0.58-0.97). The psychometric properties of the individual functional performance tests were also tested and found to be reliable (ICCs =0.88-1) and valid (r=0.32-0.63). Measurement error ranged 0-40% and the minimum change needed to detect true clinical change was calculated for each test. Balance disability, measured with the Brunel Balance Assessment, is heterogeneous with sitting, standing and stepping balance forming distinct levels of ability (p<0.027). Consequently, the BBA could be used to stratify people with stroke according to balance ability. Weakness, sensation and age were significant independent contributors to balance disability (r2=82.7%). Balance ability was a strong contributor to independence in ADL (p<0.0001). The findings of this thesis address the issues that have limited research into stroke physiotherapy with regard to balance disability. In relation to clinical practice, a robust measurement and stratification tool has been developed.

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