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Risikofaktoren für Blutungskomplikationen nach ÖsophagusvarizenligaturGrothaus, Johannes 09 July 2012 (has links) (PDF)
Esophageal varices are expanded veins of the submucosa that develop in patients with portal hypertension. They develop as collaterals between the portal vein and the superior vena cava. Varices are seen when the HPVG rises >12mmHG and can lead to a life-threatening bleeding episode. Endoscopic band ligation (EBL) is the treatment of choice of acute variceal bleeding. It is also performed for primary and secondary prophylaxis of bleeding from esophageal varices. After EBL, patients are at risk of postinterventional bleeding. Therefore, patients are often hospitalized until endoscopy proves all applied ligation bands have dropped off. At present, there is no standardized algorithm for surveillance of patients after EBL. Furthermore, risk factors for bleeding complications after EBL are poorly evaluated. The available studies mostly investigated patient collectives .after endoscopic sclerotherapy. The aim of this study was to investigate bleeding behaviour after EBL, to make recommendations for in- and out-patient surveillance after EBL and to analyze independent risk factors for bleeding complications after EBL.
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Unterschiede im Blutungsverhalten nach ÖsophagusvarizenligaturPetrasch, Florian 20 October 2011 (has links) (PDF)
Background: Endoscopic band ligation (EBL) is generally accepted as the treatment of choice for bleeding from
esophageal varices. It is also used for secondary prophylaxis of esophageal variceal hemorrhage. However, there is
no data or guidelines concerning endoscopic control of ligation ulcers. We conducted a retrospective study of EBL
procedures analyzing bleeding complications after EBL.
Methods: We retrospectively analyzed data from patients who underwent EBL. We analyzed several data points,
including indication for the procedure, bleeding events and the time interval between EBL and bleeding.
Results: 255 patients and 387 ligation sessions were included in the analysis. We observed an overall bleeding rate
after EBL of 7.8%. Bleeding events after elective treatment (3.9%) were significantly lower than those after
treatment for acute variceal hemorrhage (12.1%). The number of bleeding events from ligation ulcers and variceal
rebleeding was 14 and 15, respectively. The bleeding rate from the ligation site in the group who underwent
emergency ligation was 7.1% and 0.5% in the group who underwent elective ligation. Incidence of variceal
rebleeding did not vary significantly. Seventy-five percent of all bleeding episodes after elective treatment occurred
within four days after EBL. 20/22 of bleeding events after emergency ligation occured within 11 days after
treatment. Elective EBL has a lower risk of bleeding from treatment-induced ulceration than emergency ligation.
Conclusions: Patients who underwent EBL for treatment of acute variceal bleeding should be kept under medical
surveillance for 11 days. After elective EBL, it may be reasonable to restrict the period of surveillance to four days
or even perform the procedure in an out-patient setting.
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Modelos de fração de cura aplicados aos tempos de sobrevivência de pacientes submetidos à ligadura elástica de varizes no esôfagoGalletti, Agda Jéssica de Freitas January 2018 (has links)
Orientador: Rogério Antonio Oliveira / Resumo: A cirrose é uma doença hepática assintomática que, muitas vezes, é descoberta quando o quadro é irreversível. Por isso, o tratamento consiste em uma série de medidas para controlar o avanço da enfermidade, visto que a principal consequência da cirrose é o aumento da pressão na veia portal, que por sua vez, acarreta no surgimento de varizes e no seu respectivo rompimento, podendo ser fatal. Estudos relacionados à esta doença são muito importantes, pois a análise estatística é uma ferramenta que permite auxiliar na tomada de decisões nos procedimentos médicos e acompanhamento de pacientes. Um método estatístico bastante explorado nas ciências biomédicas é a análise de sobrevivência, que consiste em descrever o tempo de um evento inicial até a ocorrência de um outro de interesse. No entanto, existem situações em que uma proporção da amostra não vivencia o desfecho de interesse, mesmo que acompanhado por um período longo de tempo. Nestes casos, tais observações são dita imunes ao desfecho de interesse e as metodologias tradicionais de análise de sobrevivência não são indicadas. Logo, os modelos de fração de cura ou de longa duração, desenvolvido a partir do modelo de mistura, são os utilizados nestas situações. Neste trabalho diverso modelos foram considerados para analisar os tempos de vida de pacientes submetidos à Ligadura Elástica de Varizes Esofágicas, ao qual foram anotados os tempos até o óbito durante o acompanhamento de 129 pacientes do Hospital das Clínicas da Faculdade... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Cirrhosis is an asymptomatic liver disease that is often discovered when the patient's condition is irreversible. Therefore, the treatment consists of a series of measures to control the progression of the disease, since the main consequence of the cirrhosis is the increase of the portal venous pressure, which causes the appearance of varices and their respective rupture may be fatal. Studies related to that disease are very important, so the statistical analysis is a tool that helps to make decisions in medical procedures and patient follow-up. The most applied statistical method in the biomedical sciences is survival analysis, which consists of describing the time of occurrence until the event of interest. However, there are situations in which a proportion of the sample does not experience the interest outcome, even if they are accompanied by a long period of time. In such cases, such observations are said to be immune to the outcome of interest and traditional survival analysis methodologies are not appropriated. Therefore, the care fraction or long duration models can be used in these situations because they incorporate mixtures of models to solve the complexity inherent in the actual study. In this work, some statistical models were considered to analyze the survival times of patients, after surgery of Endoscopic Band Ligation of the Esophageal Varices, such as Exponential, Gamma and Weibull models. The data is related to survival times of 129 patients, who were treated... (Complete abstract click electronic access below) / Mestre
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Modelos de fração de cura aplicados aos tempos de sobrevivência de pacientes submetidos à ligadura elástica de varizes no esôfago / Cure rate models applied to the patients survival times submitted to endoscopic band ligation of the esophageal varicesGalletti, Agda Jéssica de Freitas 23 February 2018 (has links)
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Previous issue date: 2018-02-23 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A cirrose é uma doença hepática assintomática que, muitas vezes, é descoberta quando o quadro é irreversível. Por isso, o tratamento consiste em uma série de medidas para controlar o avanço da enfermidade, visto que a principal consequência da cirrose é o aumento da pressão na veia portal, que por sua vez, acarreta no surgimento de varizes e no seu respectivo rompimento, podendo ser fatal. Estudos relacionados à esta doença são muito importantes, pois a análise estatística é uma ferramenta que permite auxiliar na tomada de decisões nos procedimentos médicos e acompanhamento de pacientes. Um método estatístico bastante explorado nas ciências biomédicas é a análise de sobrevivência, que consiste em descrever o tempo de um evento inicial até a ocorrência de um outro de interesse. No entanto, existem situações em que uma proporção da amostra não vivencia o desfecho de interesse, mesmo que acompanhado por um período longo de tempo. Nestes casos, tais observações são dita imunes ao desfecho de interesse e as metodologias tradicionais de análise de sobrevivência não são indicadas. Logo, os modelos de fração de cura ou de longa duração, desenvolvido a partir do modelo de mistura, são os utilizados nestas situações. Neste trabalho diverso modelos foram considerados para analisar os tempos de vida de pacientes submetidos à Ligadura Elástica de Varizes Esofágicas, ao qual foram anotados os tempos até o óbito durante o acompanhamento de 129 pacientes do Hospital das Clínicas da Faculdade de Medicina da UNESP, Campus Botucatu (SP), no período de 2006 a 2010. O modelo Weibull Modificado com fração de cura foi considerado adequado, indicando que quanto maior a idade e o grau da doença hepática, se os pacientes não usam o medicamento Beta-Bloqueador e são homens, menor é a chance deles serem sobreviventes de longa duração. / Cirrhosis is an asymptomatic liver disease that is often discovered when the patient's condition is irreversible. Therefore, the treatment consists of a series of measures to control the progression of the disease, since the main consequence of the cirrhosis is the increase of the portal venous pressure, which causes the appearance of varices and their respective rupture may be fatal. Studies related to that disease are very important, so the statistical analysis is a tool that helps to make decisions in medical procedures and patient follow-up. The most applied statistical method in the biomedical sciences is survival analysis, which consists of describing the time of occurrence until the event of interest. However, there are situations in which a proportion of the sample does not experience the interest outcome, even if they are accompanied by a long period of time. In such cases, such observations are said to be immune to the outcome of interest and traditional survival analysis methodologies are not appropriated. Therefore, the care fraction or long duration models can be used in these situations because they incorporate mixtures of models to solve the complexity inherent in the actual study. In this work, some statistical models were considered to analyze the survival times of patients, after surgery of Endoscopic Band Ligation of the Esophageal Varices, such as Exponential, Gamma and Weibull models. The data is related to survival times of 129 patients, who were treated in the Hospital das Clínicas of the Medical School of UNESP, Campus Botucatu (SP), from 2006 to 2010. The Modi ed Weibull distribution with cure rate was considered adequate to the data, indicating that older male patients with higher Child-Pugh score without taking beta blockers medicine are more likely not to be a long-term survivor.
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Unterschiede im Blutungsverhalten nach ÖsophagusvarizenligaturPetrasch, Florian 22 September 2011 (has links)
Background: Endoscopic band ligation (EBL) is generally accepted as the treatment of choice for bleeding from
esophageal varices. It is also used for secondary prophylaxis of esophageal variceal hemorrhage. However, there is
no data or guidelines concerning endoscopic control of ligation ulcers. We conducted a retrospective study of EBL
procedures analyzing bleeding complications after EBL.
Methods: We retrospectively analyzed data from patients who underwent EBL. We analyzed several data points,
including indication for the procedure, bleeding events and the time interval between EBL and bleeding.
Results: 255 patients and 387 ligation sessions were included in the analysis. We observed an overall bleeding rate
after EBL of 7.8%. Bleeding events after elective treatment (3.9%) were significantly lower than those after
treatment for acute variceal hemorrhage (12.1%). The number of bleeding events from ligation ulcers and variceal
rebleeding was 14 and 15, respectively. The bleeding rate from the ligation site in the group who underwent
emergency ligation was 7.1% and 0.5% in the group who underwent elective ligation. Incidence of variceal
rebleeding did not vary significantly. Seventy-five percent of all bleeding episodes after elective treatment occurred
within four days after EBL. 20/22 of bleeding events after emergency ligation occured within 11 days after
treatment. Elective EBL has a lower risk of bleeding from treatment-induced ulceration than emergency ligation.
Conclusions: Patients who underwent EBL for treatment of acute variceal bleeding should be kept under medical
surveillance for 11 days. After elective EBL, it may be reasonable to restrict the period of surveillance to four days
or even perform the procedure in an out-patient setting.
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Risikofaktoren für Blutungskomplikationen nach ÖsophagusvarizenligaturGrothaus, Johannes 03 May 2012 (has links)
Esophageal varices are expanded veins of the submucosa that develop in patients with portal hypertension. They develop as collaterals between the portal vein and the superior vena cava. Varices are seen when the HPVG rises >12mmHG and can lead to a life-threatening bleeding episode. Endoscopic band ligation (EBL) is the treatment of choice of acute variceal bleeding. It is also performed for primary and secondary prophylaxis of bleeding from esophageal varices. After EBL, patients are at risk of postinterventional bleeding. Therefore, patients are often hospitalized until endoscopy proves all applied ligation bands have dropped off. At present, there is no standardized algorithm for surveillance of patients after EBL. Furthermore, risk factors for bleeding complications after EBL are poorly evaluated. The available studies mostly investigated patient collectives .after endoscopic sclerotherapy. The aim of this study was to investigate bleeding behaviour after EBL, to make recommendations for in- and out-patient surveillance after EBL and to analyze independent risk factors for bleeding complications after EBL.
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