Section A provides an overview of the role of family caregivers of individuals with chronic illness, and describes key conceptualisations and theories posited in the caregiver literature. This is followed by an overview of research conducted with caregivers of children with chronic kidney disease (CKD), a summary of the limitations of this research, and suggestions for future research. Section B Despite a recognised need to monitor caregiver burden in caregivers of children with CKD, there is no measurement tool currently available to meet this aim. The present research documents the development of a measure of caregiver burden specific to family caregivers of children with CKD. Methods: Interviews were conducted with 16 caregivers of children with CKD and 10 healthcare professionals in order to generate measure items. A provisional version of the measure was developed and piloted with 18 caregivers of children with CKD and five healthcare professionals. Results: An initial pool of 97 items was generated from the content of interviews, which was reduced to 60 items following review for item redundancy. A piloting exercise provided preliminary evidence for the usability, readability, and relevance of measure items; adaptations further to piloting resulted in the 51-item ‘Paediatric Renal Caregiver Burden Scale’ (PR-CBS). Conclusions: It is hoped that the PR-CBS will serve to identify areas of need amongst caregivers of children with CKD, and in turn improve outcomes for this caregiver population and children with CKD. Section C is a critical appraisal of the conducted research study, and includes an overview of research abilities acquired during its completion, reflections on how the research may have been conducted differently, implications for future clinical practice, and ideas for future research.

Section A provides an overview of the literature investigating the relationship between parental mental health and child physical health within populations of children with chronic childhood illness. Evidence for whether this relationship definitively exists, as well as the potential pathways through which this relationship could operate, is evaluated. Carers of children with Chronic Kidney Disease (CKD) can experience burden and psychological distress, which has been shown to impact on the child's physical health. Section B is an empirical study aiming to assess the validity and reliability of the Paediatric Renal Carer Burden Scale (PR-CBS) , a 51 item psychometric measure designed to assess carer burden in carers of children with CKD. Factor analysis indicated retention of 21 items representing 5 factors; Illness worries (8 items), Impact on self (5 items), Impact on child (3 items), Responsibility (3 items) and Institutional burden (2 items). Together they explain 53% of the total variance. Internal reliability for both the full scale and sub-scales were acceptable. Convergent validity was demonstrated using the Hospital Anxiety and Depression Scale and Caregiver Strain Questionnaire and the scale was reported by respondents as being acceptable to complete. The PR-CBS has been shown to be a valid and reliable scale and as such is a clinically relevant tool with which to identify burdened carers and provide additional psycho-social support so as to ensure best outcomes for both carer and child. Section C provides a critical evaluation of the research process and reflections from the researcher on learning throughout the process of the study as well as clinical implications and future research directions.