Adrenals from adult male mice, when incubated in Krebs-Ringer bicarbonate glucose solution, produce corticosterone, aldosterone, and a polar lipid with the properties of 18-hydroxycorticosterone; the polar fraction also contains other reducing lipids. [...]

Generally, a few days after an animal, or man, is exposed to natural infection or is subjected to active immunization, antibodies possessing the property of combining specifically with the homologous antigen, i.e. antigen responsible for the sensitization, appear in circulation (1). [...]

Glycogen was first isolated by Claude Bernard (1) from dog liver in 1857 and during the following two years was extracted from a variety of tissues, including skeletal muscle, placental tissue and epithelial cells (2). Kulz et al (3) identified glucose as the product of the acid hydrolysis of glycogen and Seegen (4) demonstrated the ability of saliva, pancreatic juice and diastase to degrade the polysaccharide enzymatically. [...]

In the rat, intraperitoneal injection of vanillin gave rise to a number of urinary products, the most important being vanillic acid ( free and conjugated ). Some vanillin and vanillyl alcohol were excreted as conjugates. Catechol was a minor metabolite; it was produced not only by normal rats, but also by animals treated with neomycin and streptomycin, to reduce the intestinal flora. [...]

The work presented in this thesis represents, in part, an effort to ascertain some of the biochemical changes that occur in the aorta during the development of otherosclerosis. My interest was first stimulated during the course in pathology in the early part of medical training. [...]

Selye was the first to show that apparently unrelated, non-specific stimuli, termed "Stressors", challenge the body's tendency to maintain homeostasis and trigger a sequence of physiological events which are attributed to the actions of adrenocorticotrophin (ACTH)(l)(2). The actions of ACTH include eosinopenia, involution of the lymphoid tissues, the enlargement of the adrenal cortex with the synthesis and release of adrenocortical steroids and the depletion of adrenal cholesterol and adrenal ascorbic acid (2). [...]

In the past two decades the physiological role of adipose tissue has been the subject of intensive research. Besides serving as an insulator and mechanical buffer its major metabolic function has been found to be the storage of triglyceride as a potential source of energy. Fat is a particularly dense form of stored energy. [...]

The work described in this thesis is a part of a larger project on the metabolism of mammalian tissues in vitro and the effect of hormones thereon, which is under progress at the McGill University Clinic, Royal Victoria Hospital, Montreal. The original intention had been to first establish parameters for the utilization of glucose for lipid synthesis by human adipose tissue, and then to extend the investigations to tissue from obese and diabetic patients. [...]

Early ideas ef the cell membrane as a structural sac that permitted the passage of molecules en the basis of their size, lipid selubility, and charge have been extensively revised in the past few decades. The cell membrane is new regarded as a dynamic part ef the cell itself with specialized roles to play in the regulation of the composition of the cell interior and in the supply of nutrients to the cell's metabolic machinery. [...]

The release and uptake of copper was studied in many tissues of the rat in vivo and in vitro in copper deficiency and loading experiments. Severe to moderate depletion of the metal was observed in the tissues of deficient animais. Liver, heart and blood were found most sensitive to lack of dietary copper. [...]