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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
81

Investigation of Magnesium-based Interventions for Central and Peripheral Nervous Tissue Regeneration

Vennemeyer, John J. 30 September 2013 (has links)
No description available.
82

Poly(ester urea)s for Biomedical and Drug Delivery Applications

Abel, Alexandra K. 01 December 2021 (has links)
No description available.
83

The Design of a Biodegradable Stent for Arteriovenous Fistula Maturation and a Carbon Nanotube Membrane for Water Filtration

Xu, Chenhao 23 August 2022 (has links)
No description available.
84

Increasing elastin fibre production in a tissue engineered mesh for pelvic floor surgery

Osman, N., Roman, S., Sefat, Farshid, Bullock, A.J., Chapple, C.R. January 2014 (has links)
yes / Polypropylene mesh for pelvic floor surgery is associated with serious complications ( e.g. erosion). A biodegradable tissue engineered mesh composed of a polylactic acid (PLA) scaffold seeded with autologous cells is a promising alternative. However, thus far elastin content (important for elastic recoil) in this tissue has been low. We aimed to increase elastin expression and test the resultant tensile properties.
85

Polyester-based Biodegradable Systems Incorporating POSS

Knight, Pamela Tiffany January 2010 (has links)
No description available.
86

Synthesis of Pegylated Poly(lactic acid) Via Radical Coupling

Zhang, Zheng 01 June 2015 (has links)
No description available.
87

Biodegradable Magnesium Implants for Medical Applications

Tiasha, Tarannum R. 16 June 2017 (has links)
No description available.
88

Sensing as a tool to monitor magnesium based material corrosion in aqueous solutions

Kuhlmann, Julia 05 October 2012 (has links)
No description available.
89

Anodized TiO<sub>2</sub> Nanotube Film For Controllable Drug Delivery

Jia, Huiying 20 August 2013 (has links)
No description available.
90

Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles

Lu, Hao 07 June 2011 (has links)
Different structures of non-viral cationic polymer delivery vehicles, including charge center type, molecular weight and degradability, could significantly affect toxicity, release of nucleic acid and transfection efficiency. Poly(glycoamidoamine)s (PGAAs) contained different carbohydrate and secondary amine moieties and showed high transfection efficiency to different cell lines in a nontoxic manner. The "proton sponge hypothesis" has attempted to relate the buffering capacity to endosomal release of polyethylenimine (PEI) based polyplexes, which could contribute to high transfection efficiency. Secondary amine structures rendered PGAAs buffering capacity around physiological pH. To test the feasibility of the mechanism for PGAAs, new no buffering capacity guanidine or methylguanidine containing poly(glycoamidoguanidine)s (PGAGs) were synthesized. PGAGs formed stable polyplexes with pDNA from N/P (# secondary amine or guanidine group on polymer backbone / # phosphate group on pDNA backbone) ratio 3. PGAG based polyplexes expressed low cytotoxicity and were internalized by 90% of cells at N/P 25. Furthermore, two PGAG based polyplexes showed higher transfection efficiency from N/P 5 to 30 than their PGAA based analogs. These data suggested the low transfection could be due to the difficulties to release pDNA from polyplexes; also, the "proton sponge theory" could not explain the higher transfection efficiency by some PGAGs. Degradation of delivery vehicles could potentially release pDNA in cells and increase transfection efficiency. PGAAs degraded rapidly at physiological conditions and the proposed mechanism was amide hydrolysis. Typically, amide groups are stable and hydrolyze slowly in absence of enzyme. Different models mimicking PGAAs were synthesized to study the fast hydrolysis. Amide groups showed asymmetric hydrolysis. Different hydrolysis behaviors suggested neighboring group participation of two terminal groups to induce rapid amide hydrolysis. These new models could potentially be used to design new polymer delivery vehicles with various degradation profiles. / Master of Science

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