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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Nikola Mrázková Supervisor of Diploma thesis: Doc. RNDr. Milan Dittrich CSc. Title of Diploma thesis: Formulation of nanoparticles with terbinafine In the theoretical part of this diploma thesis is presented review concerning basic applications of nanotechnology in health service, characteristic of nanoparticles, their dividing and use in pharmacotherapy, especially in targeted drug transport. The focus of the thesis presented here is in experimental part. Particles of submicrom size were fabricated by the using of emusion solvent distribution method in the emulsion of o/w type. Star-like terpolymer of DL- lactic acid and glycolic acid branched on tripentaerytritole as core was used as potential drug carrier. The aim was to prepare the smallest particles as possible. The size and the size distribution were measured by the PCS method by the using of the device Zeta Sizer ZS. The impact of two from the chemical point of view different emulsifiers and two emulsion concentrations on the granulometric parameters of the prepared particles was evaluated. The stability of parameters during storage at lowered temperature and in the frozen state during the one day period after preparation was...

Univerzita Karlova v Praze Farmaceutická fakulta v Hradci Králové Katedra farmaceutické technologie Studentka: Eliška Königová Vedoucí diplomové práce: Doc. RNDr. Milan Dittrich CSc. Název práce: Influence of solvent on the size of polyester nanoparticles In the theoretical part of this thesis the methods of fabrication of nanoparticles and their evaluation are described. It further explores the biodegradable polymer of glycolic acid and lactic acid and in particular the nanoparticles prepared from this polymer. The main objective were the results of an experiment which explored some of the technological parameters of formulation of biodegradable particles made from terpolymer of DL-lactic acid, glycolic acid and tripentaerythritole by o/w emulsion method. The aim was to create the smallest possible nanoparticles using the standard procedure. The study sought the optimal concentration of emulsifier cetrimide. It evaluated the influence of the concentration of emulsion and the concentration of the polyester carrier and terbinafine as a model drug for the assessment of granulometric parameters of prepared particles. For an intended use of the method the storage of samples at low temperature after the addition of mannitol was granulometrically evaluated.

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Thesis (M.S.)--University of North Texas, Dec., 2009. / Title from title page display. Includes bibliographical references.

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Orientadores: Cecilia Amelia de Carvalho Zavaglia, Elisabete Maria Saraiva Sanchez / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecanica / Made available in DSpace on 2018-08-14T04:04:59Z (GMT). No. of bitstreams: 1 Salgado_ChristianeLaranjo_D.pdf: 5240201 bytes, checksum: 742780e9772eab669c561213d9c224bd (MD5) Previous issue date: 2009 / Resumo: A engenharia tecidual é um campo emergente na biomedicina moderna, que promete um novo caminho de esperança para o transplante biológico, criando substitutos viáveis para órgãos e tecidos danificados. O objetivo primordial de várias das estratégias desta terapia que está sendo desenvolvida é regenerar estrutural e funcionalmente, os tecidos lesionados ou perdidos utilizando células em combinação com matrizes sintéticas. Pensando nesta problemática, foi desenvolvido um biomaterial, na forma de arcabouço porosa obtida por evaporação do solvente orgânico. Este material foi utilizado nas primeiras avaliações da blenda polimérica e a seguir foi desenvolvida semelhante matriz como gel, com o intuito de possibilitar a introdução do biomaterial ao organismo humano por meio de uma seringa de injeção comum. Foi utilizada uma policaprolactona (PCL) de alta massa molecular combinada com um polímero natural, ácido sebácico (AS), derivado do óleo de rícino, com baixa massa molecular, para acelerar o tempo de degradação. Os materiais foram caracterizados termicamente (DSC, TGA e DMA), mecanicamente (ensaio de tração) e microscopicamente (MEV e OPM). Foi também analisada sua degradação em solução salina (PBS). Como resultados, foram verificados que o material (PCL/AS) mantém as mesmas propriedades térmicas do polímero puro, sendo elas alteradas à medida que se aumenta a percentagem de AS (10 e 20 %), no entanto o tempo de degradação é relativamente menor. A biocompatibilidade foi analisada por protocolos conhecidos e padronizados (ASTM e ISO) e podemos concluir que o material é compatível com cultura de células. O biomaterial em forma de gel favoreceu a diferenciação de células mesenquimais (medida pela atividade de ALP). Em avaliações in vivo (implantes subcutâneos) utilizando ratos Wistar, tanto a arcabouço quanto o gel promoveram regeneração do tecido no qual o material foi implantado e reações adversas não foram observadas. / Abstract: Tissue engineering, a new emerging field in modern biomedical sciences, promises a new ray of hope for transplantation biology by creating viable substitutes for such failing organs or tissues. The ability to manipulate and reconstitute tissue function has tremendous clinical implications and is likely to play a key role in cell and gene therapies in the coming years. Thinking about this problem, we developed a biomaterial, either in form of a membrane (casting) or as a gel. The last one could be injected on the human body with a common syringe. For this purpose it was prepared with high molecular weight polycaprolactone (PCL) and a natural polymer, sebacic acid (SA), a part of castor oil with low molecular weight to accelerate the degradation rate. Thermal analyses were carried out to characterize the materials (DSC, TGA e DMA). The material's mechanical resistance was evaluated, as well as its surface by microscopy (SEM and OPM). The hydrological degradation was evaluated though exposure to saline solution (PBS). We used well known protocols (ASTM and ISO) to evaluate the material's biocompatibility and the degradation rate. The results allowed us to conclude that the gel is biocompatible, promote the differentiation of MSC's and presented a degradation rate adequate to be used in bone tissue engineering. Wistar's rats were used for in vivo evaluation. Both membrane and gel blends promoted tissue regeneration and adverse reactions were not observed on subcutaneous implants. / Doutorado / Materiais e Processos de Fabricação / Doutor em Engenharia Mecânica