151 |
Über ein neues alkaloid aus conium Maculatum, sein konstitution und versuche zu seiner syntheseAdam, Georg. January 1891 (has links)
Thesis (doctoral)--Universität Breslau, 1891.
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152 |
Vitamin B₁₂ and deoxyribose biosynthesis in Lactobacillus leichmanniiSpell, William Hux. January 1961 (has links)
Thesis (Ph. D.)--University of Arkansas, Fayetteville, 1961. / Includes bibliographical references (leaves 114-132).
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153 |
Analysis and characterization of vitamin B biosynthesis pathways in the phytoparasitic nematode Heterodera glycinesCraig, James P. January 2009 (has links)
Thesis (Ph.D.)--University of Illinois, 2009. / Vita. Includes bibliographical references.
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154 |
Enzymatic studies of serine biosynthesis in animal systemsWalsh, Donal Arthur, January 1966 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1966. / Typescript. Vita. Description based on print version record. Includes bibliographical references (156-162).
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Penicillin acyl-group transfer and hydrolysis in microorganismsPruess, David Louis, January 1967 (has links)
Thesis (Ph. D.) University of Wisconsin, 1967. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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156 |
Formation and modification of enduracididine, a nonproteinogenic amino acid /Tan, Ying. January 1900 (has links)
Thesis (M.S.)--Oregon State University, 2006. / Printout. Includes bibliographical references. Also available on the World Wide Web.
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157 |
Regulation of arabidopsis trichome patterning and anthocyanin biosynthesis by the TTG1-bHLH-MYB complexZhao, Mingzhe, January 1900 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.
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158 |
Structure-function relationships of alpha lactalbuminPike, Ashley C. W. January 1995 (has links)
No description available.
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159 |
An enantioselective synthesis of substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocinesWilliams, Colin Stephen January 1990 (has links)
No description available.
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160 |
Genome mining for actinomycete biosynthetic gene clustersDudbridge, Frederic Henry January 2018 (has links)
Whole-genome sequencing has shown that the large (8-12 Mbp) genomes of Streptomyces and allied genera of Gram-positive filamentous bacteria house a rich and previously underestimated repertoire of gene clusters for biosynthesis of specialised metabolites, including antibiotics, immunosuppressants and anticancer compounds. Many of these clusters remain uncharacterised because they are not expressed under the culture conditions used. Even for strains from which a specific compound has been identified, the challenge remains to link the compound to its gene cluster, and to develop procedures for analysing and manipulating the biosynthetic pathway. In this work, three strains have been studied that address different aspects of this challenge. Streptomyces sp. DSM4137 is a genetically amenable strain and a notably prolific producer of diverse natural products, but also has multiple biosynthetic gene clusters that remain uncharacterised. In an attempt to differentiate those clusters where the genes are expressed from those that are essentially silent, the transcriptome of DSM4137 was analysed using total RNASeq and the results were used to inform analysis of HPLC/MS data of extracts under the same conditions. There was shown to be good correlation between the RNASeq results and the pattern of metabolites produced, suggesting that RNASeq may be a useful complement in the search for novel gene clusters. In contrast, Saccharopolyspora spinosa, producer of the valuable insecticidal spinosyns, is not genetically amenable. A new technique has been developed for the mobilisation of an entire biosynthetic gene cluster and refactoring attempted to increase the production of spinosyns in a heterologous strain. Total transcriptome was analysed by RNAseq to give an insight into the regulation of the WT strain, helping identify future methods for strain manipulation for increase yields.
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