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In the field of nuclear medicine, radioisotopes are used for applications such as diagnostic imag- ing, treatment, and equipment sterilization. The most commonly used radioisotope in medicine is technetium-99m (Tc-99m). It is used in 80% of all nuclear medicine procedures. Its parent isotope is molybdenum-99 (Mo-99). NRU, which is now closed, formerly produced 40% of the worlds demand for Mo-99. The production capacity of this reactor has been supplemented by a network of cyclotrons and a modified research reactor. This study aims to provide an alternative means of production for Mo-99, as well as other radioisotopes by modifying the center pin of a standard 37-element bundle of a CANDU reactor. The neutron transport code DRAGON, and the neutron diffusion code DONJON were used to model a CANDU-9 reactor. The lowest, median, and highest power channels were chosen as candi- dates for the modified bundles. It was found that the reactor parameters were altered by a negligible amount when any one channel was used to house the modified bundles. Significant quantities of the radioisotope lutetium-177 as well as the generating isotopes of the alpha-emitting radioisotopes lead- 212/bismuth-212, and radium-223 were produced. However, only minute amounts of molybdenum-99, and the generating isotope of bismuth-213 were produced. / Thesis / Master of Applied Science (MASc)