A finite element model was developed for a range of human head-sUAS impacts to provide multiple case scenarios of impact severity at two response regions of interest: global and local. The hypothesis was that for certain impact scenarios, local response injuries of the brain (frontal, parietal, occipital, temporal lobes, and cerebellum) have a higher severity level compared to global response injury, the response at the Center of Gravity (CG) of the head. This study is the first one to predict and quantify the influence of impact parameters such as impact velocity, location, offset, and angle of impact to severity of injury. The findings show that an sUAS has the potential of causing minimal harm under certain impact scenarios, while other scenarios cause fatal injuries. Additionally, results indicate that the human head’s global response as a less viable response region of interest when measuring injury severity for clinical diagnosis. It is hoped that the results from this research can be useful to assist decision making for treatments and may offer different perspectives in sUAS designs or operation environments.