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Borinic Acid-catalyzed Regioselective Functionalization of PolyolsWilliamson, Caitlin 04 January 2012 (has links)
The selective manipulation of hydroxyl groups in di- and polyols is a frequently encountered problem in organic synthesis. Such processes are often tedious and/or moderate yielding, and often necessitate multistep protection / deprotection sequences. Applying boron–diol interactions previously exploited in molecular recognition and based on methods previously developed in our research group, we have developed two classes of chemical transformations:
1. Regioselective sulfonylations of carbohydrate derivatives catalyzed by a borinic ester, providing access to the corresponding mono-tosylates in high yields;
2. Selective monoalkylations and monosulfonylations of structurally diverse 1,2- and 1,3-diol substrates.
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Borinic Acid-catalyzed Regioselective Functionalization of PolyolsWilliamson, Caitlin 04 January 2012 (has links)
The selective manipulation of hydroxyl groups in di- and polyols is a frequently encountered problem in organic synthesis. Such processes are often tedious and/or moderate yielding, and often necessitate multistep protection / deprotection sequences. Applying boron–diol interactions previously exploited in molecular recognition and based on methods previously developed in our research group, we have developed two classes of chemical transformations:
1. Regioselective sulfonylations of carbohydrate derivatives catalyzed by a borinic ester, providing access to the corresponding mono-tosylates in high yields;
2. Selective monoalkylations and monosulfonylations of structurally diverse 1,2- and 1,3-diol substrates.
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