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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
361

Graduate midwives and breastfeeding support : what factors influence the development of their practice?

Reddin, Edith January 2009 (has links)
Breastfeeding is an important public health initiative that has many benefits for mother and baby. Promoting and encouraging breastfeeding is an important role for all health professionals and particularly for midwives who have contact with women during their pregnancy and in the immediate postnatal period. Midwives have a crucial role in providing breastfeeding support and education during the postnatal period. However, little exists in the literature regarding the way midwifery students and graduates develop this role. This thesis investigates factors that impact on the development of breastfeeding support practice for newly graduated midwives. / PhD Doctorate
362

Cross-talk between CXCR4 and IGF-1R signal transduction pathways in a metastatic breast cancer cell line.

Akekawatchai, Chareeporn January 2007 (has links)
Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / "The present study investigated the expression and function of IGF-1R, CXCR4 and CCR7, in metastatic MDA-MB-231 and non-metastatic MCF-7 cells." / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1295746 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2007
363

Apo2L/TRAIL in breast cancer bone metastasis: in vitro and in vivo studies into molecular mechanisms of action and resistance.

Thai, Le Minh January 2007 (has links)
Title page, table of contents and summary only. The complete thesis in print form is available from the University of Adelaide Library. / This thesis describes two studies, one in vitro and one in vivo, which show that Apo2L/TRAIL can prevent breast cancer-induced bone destruction, and highlight the potential of this ligand for the treatment of metastatic breast cancer in bone. They also highlight the complexity of Apo2L/TRAIL signalling, and the need for further studies into this area to fully exploit the potential of Apo2L/TRAIL as an anti-cancer agent for breast and other cancers. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1283688 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2007
364

Apo2L/TRAIL in breast cancer bone metastasis: in vitro and in vivo studies into molecular mechanisms of action and resistance.

Thai, Le Minh January 2007 (has links)
Title page, table of contents and summary only. The complete thesis in print form is available from the University of Adelaide Library. / This thesis describes two studies, one in vitro and one in vivo, which show that Apo2L/TRAIL can prevent breast cancer-induced bone destruction, and highlight the potential of this ligand for the treatment of metastatic breast cancer in bone. They also highlight the complexity of Apo2L/TRAIL signalling, and the need for further studies into this area to fully exploit the potential of Apo2L/TRAIL as an anti-cancer agent for breast and other cancers. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1283688 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2007
365

Contributions to the early diagnosis and modern management of breast cancer.

Farshid, Gelareh January 2010 (has links)
Title page, table of contents and summary only. The complete thesis in print form is available from the University of Adelaide Library. / I hereby submit a body of original research for consideration of the award of Doctor of Medicine from the University of Adelaide. This is a collection of published original research that has made substantial contributions to the modern diagnosis and management of breast cancer. The publications have been presented in three clusters, each of which represents one facet of the modern approach to the diagnosis and management of breast cancer. The first section presents my publications on the theme of population based mammographic screening for the early detection of breast cancer. Broadly, the research focus in these publications is on the evaluation of existing methods of assessment of screen-detected breast lesions in order to improve diagnostic accuracy and limit the morbidity associated with mammographic screening. The clinical value of these contributions has been demonstrated independently since this body of work has informed many of the algorithms and protocols used by the South Australian breast cancer screening program. In addition, the protocols have been adopted for use outside of the screening setting into the wider diagnostic arena. The clinical endorsement of my research contributions is a significant acknowledgement of their practical value. The middle group of publications describe my contributions towards the evolving role of sentinel node biopsy as an alternative to axillary clearance for the staging of breast cancer. This area is of particular cogent to our setting, since a large proportion of screen-detected breast cancers, approximately 80%, are node negative. Thus, avoidance of the morbidity of axillary clearance while still achieving accurate axillary staging is of enormous appeal to our patients. My pioneering work in devising and evaluating protocols for the pathologic examination of sentinel nodes has informed the recommendations of the NHMRC sponsored SNAC (Sentinel Node versus Axillary Clearance) randomised trial. Consequently, these protocols have been used extensively and even outside of the trial setting, most pathology laboratories utilise similar assessment protocols as was recommended in SNAC. Furthermore, the United Kingdom's recommendations for the pathology examination of sentinel nodes have drawn on our research. After validating the concept of SNs in breast cancer, many of the clinically important questions emerging in this field have been addressed by our team. For example, my work on intra-operative imprint cytology was a conclusive demonstration of the value and limitations of this technique for one stage axillary surgery. In the light of our findings intra-operative assessment of sentinel nodes has been expanded to many centres and is endorsed by the SNAC trial. In the third section of this thesis, my contributions to the rapidly evolving field of molecular and genetics of breast cancer are highlighted . Through the Australian HER2 Advisory Board, we have led the evaluation and roll out of alternative platforms for HER2 testing and in developing algorithms for the efficient use of resources. We have devised national testing algorithms in both settings of metastatic and early breast cancer. These algorithms have since been utilised by the international HER2 testing bodies. In a further bold initiative, our group pioneered the move to the national adoption of bright field In situ hybridization as the first line testing platform for all newly diagnosed breast cancers throughout Australia. This ambitious undertaking entailed design and implementation of a nation-wide program of training, certification, quality assurance and evaluation. It has been deployed successfully and under my leadership, our laboratory was one of only four laboratories in Australia to commence this test in October 2006. Similarly, in the area of the genetics of breast cancer, my interest in this field and membership of the pathology subcommittee of KCONFAB has provided opportunities to contribute to significant new knowledge that illustrate the role of pathology in identification of mutation associated breast cancers. Under my leadership, our multi-centre studies have provided cogent arguments in favour of the inclusion of the histopathologic and immunophenotypic characteristics of breast cancers in the triage of patients for genetic testing. These results were published in pre-eminent pathology journals and have been referred to at major scientific conferences. Plans are afoot for the future extensions of this work. I am committed to utilising my expertise for the provision of high quality diagnostic services as part of a multi-disciplinary team involved in the treatment of women with breast diseases. I believe an evidence-based approach is central to achieving continuous improvements in these efforts. I am persuaded that there is substantial evidence demonstrating the value of population based mammographic screening in interrupting the natural history of breast cancer and reducing mortality from this disease. I am grateful to have the opportunity to contribute to the provision of this care. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1473394 / Thesis (M.D.) -- University of Adelaide, School of Medical Sciences, 2010
366

Surviving breast cancer a discourse analysis of breast cancer self-help groups

Bayers, Linda Sylvia January 2004 (has links)
Although there is a burgeoning canon addressing the detection, cause, treatment, and cure of breast cancer, there is a paucity of studies exploring how women survive the disruption and uncertainty breast cancer produces in their daily lives. There has been little exploration in the adult learning literature on the ways women might learn to live with breast cancer in the context of a heightened sense of mortality. Current institutional health education programs do not address the particular needs of individual women for practical and emotional support. In addition, the perspectives, resources, and knowledge of breast cancer self-help groups are not included in the literature on living with breast cancer. This study portrays survivor voices through the use of in-depth interviewing, participant observation, and document analysis. I use perspectives from feminist poststructuralism and Foucauldian discourse theory to explore the ways that the sixty-one women attending four breast cancer self-help groups in the late 1990s in urban and rural areas of Nova Scotia, Canada, learn to survive ? that is live with, through, and beyond ? breast cancer. While there was some variance in socioeconomic status and ethnicity, the participants were largely financially secure, married with children, of European descent, and between the ages of 33 and 83. This research shows that in their quest for survival, survivors moved amongst four overlapping discursive locations - the breast cancer self-help group, the family, the public sphere, and the cancer-care system with both support and conflict. Group discourses of reciprocity, self-care, temporality, and hope produce a range of discursive strategies for generating active survivor subjectivities. Through storytelling and the use of a powerful group technology, the survivor gaze, group members deconstruct the power technologies that disempower them. The analysis shows that survivors are active and resourceful in creating resistant, innovative, life-affirming, and self-respecting ways to speak themselves into social texts as authoritative and legitimate knowers, doers, and learners, producing new knowledge, resources, and truths about surviving. However, it is a major challenge for survivors to cope with the tense and contradictory effects of pervasive power and gender relations on the modes of subjectivities open to them. While masking of the postmastectomy body indicates that women are working on gendered identities, survivors are also learning to live their bodies in flux, taking up performative, cyborgian, productive, and playful bodies that challenge male-imposed definitions of what it is to be a woman, insisting on their right to define themselves. This thesis challenges the assumption that subjects must submit to the knowledge of experts in order to know, invent, and care for themselves. The research corroborates important insights from the self-help literature that self-help groups are significant social movements producing knowledgeable political subjects able to exercise power over their own lives. There is ample evidence that the expression and validation of emotions are central to knowledge construction processes. Further research is needed to examine how the knowledge produced by self-help groups can become officially recognized and utilized resources for survivors, and for those who care for and about them. / thesis (PhDEducation)--University of South Australia, 2004.
367

The impact of Iyengar yoga on demands of illness, coping, and lymphocyte NF-kB activation in breast cancer survivors

Schultz, Pamela Ellen, January 2007 (has links) (PDF)
Thesis (M.S. in exercise science)--Washington State University, December 2007. / Includes bibliographical references.
368

Newly-identified potential therapeutic targets for hormone-refractory breast cancer /

Rauh-Adelmann, Christine. January 1999 (has links)
Thesis (Ph.D.)--Tufts University, 1999. / Adviser: Shuk-Mei Ho. Submitted to the Dept. of Biology. Includes bibliographical references (leaves 169-171). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
369

Comparisons of gene expression patterns in progressive breast carcinoma and the adjacent stromal microenvironment

King, John F., January 2007 (has links)
Thesis (M.S.)--George Mason University, 2007. / Title from PDF t.p. (viewed Jan. 18, 2008). Thesis directors: Donald Seto, Anna Baranova. Submitted in partial fulfillment of the requirements for the degree of Master of Science in Bioinformatics. Vita: p. 105. Includes bibliographical references (p. 100-104). Also available in print.
370

The impact of group cognitive behavioural therapy programmes on breast cancer patients a meta-analysis /

Wong, Chi-keung, Max, January 2006 (has links)
Thesis (M. P. H.)--University of Hong Kong, 2006. / Also available in print.

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