Orientador: Jane Maria Bertocco Ezequiel / Resumo: A necessidade em proporcionar alternativas de dietas para vacas leiteiras por meio do uso da cana-de-açúcar hidrolisada é cada vez maior. Várias pesquisas foram realizadas com a cana hidrolisada com cal virgem ou hidratada, porém são poucas visando a associação da cana hidrolisada com a silagem de milho, assim como com a ureia pecuária e a ureia protegida. A partir disto, objetivou-se avaliar a inclusão da ureia na hidrólise ou diretamente no cocho sobre: a composição bromatológica e pH; digestibilidade in vitro e aparente; consumo de alimentos; produção e composição do leite; parâmetros sanguíneos e análise parcial de custos. O experimento foi realizado na FCAV/UNESP e APTA-Colina. Foi utilizada a cana-de-açúcar, cultivar IAC 86- 2480 (12 meses - 5º corte). Para a hidrólise foi utilizada a cal hidratada (MgO = 1,5%, CaO total = 72,5%, Ca (OH)2 = 95,5%) e a calda foi preparada na proporção de 0,5 kg de cal em 2 litros de água para 100 kg de cana-de-açúcar picada. Após este processo foi realizado o amontoamento do volumoso e fornecido aos animais 6 horas após a hidrólise. O trabalho foi dividido em quatro experimentos. O primeiro experimento foi realizado em DIC, disposto em esquema fatorial 2 x 2 (2 formas de utilização e 2 tipos de ureia) e avaliado a composição bromatológica e determinação do pH. No experimento 2 avaliou-se a digestibilidade in vitro, utilizando um bovino macho da raça Nelore, castrado e canulado no rúmen, com peso médio de 600 kg, como doador do conteúdo r... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Necessity to provide alternative diets for dairy cows through the use of hydrolyzed sugarcane is importantly increasing. The use of hydrolyzed sugarcane is increasingly necessary. Several researches were carried out with the hydrolyzed sugarcane with virgin lime or hydrated, but few are aimed at the association of the hydrolysis sugarcane with the corn silage, as well as with the urea cattle and the urea. From this, the objective was to evaluate the inclusion of urea in the hydrolysis or directly in the trough on: the bromatological composition and pH; in vitro and apparent digestibility; food consumption; milk production and composition; blood parameters and partial cost analysis. The experiment was carried out at FCAV / UNESP and APTA-Colina. Sugarcane was used, cultivar IAC 86-2480 (12 months -5 ° cut). Hydrated lime (MgO = 1.5%, total CaO = 72.5%, Ca (OH) 2 = 95.5%) was used for the hydrolysis and the slurry was prepared in the proportion of 0.5 kg decal in 2 liters of water to 100 kg of chopped sugarcane. After this process, the pile was harvested and fed to the animals 6 hours after the hydrolysis. The work was divided into four experiments. The first experiment was performed in DIC, arranged in a 2 x 2 factorial scheme (2 forms of use and 2 types of urea) and evaluated the bromatological composition and pH determination. In experiment 2 in vitro digestibility was evaluated using a Nelore male bovine, castrated e cannulate in the rumen, with an average weight of 600 kg,... (Complete abstract click electronic access below) / Mestre

In this thesis, the paper is divided into 2 parts, each corresponding to 2 individual projects. We started with looking into the synthesis of 3-coordinate palladium complexes incorporating a nacnac ligated system for academic interest. We utilized [{2,6-iPr2Ph)2nacnac}PdCl]2 as the precursor into synthesizing these 3-coordinate palladium complexes. Through many failed attempts of manipulating different substrates, we were able to synthesize a 4-coordinate [{(2,6-iPr2Ph)2nacnacPdCl}(NH2Ph)]. The second project deals with the application of dibromobis(1,1'-dibenzyl-3,3'-methylenediimidazolin-2,2'-diylidene)dicopper(I) complex to catalysis. We decided to focus our attentions specifically on carbonyl reduction of ketones being that hydrosilations with copper catalysts have only been recently looked at. The dibromobis(1,1'-dibenzyl-3,3'-methylenediimidazolin-2,2'-diylidene)dicopper(I) complex proved to be very effective at hydrosilations of a wide variety of ketones at high temperatures. We further investigated the scope of the dibromobis(1,1'-dibenzyl-3,3'-methylenediimidazolin-2,2'-diylidene)dicopper(I) catalyst by testing it on the arylation and alkylation of imidazole. The arylation of imidazole showed little to no conversion, whereas the alkylation proved to be quite active for both alkyl bromides and chlorides. We also looked at the attempts in synthesizing bulkier analogues of dibromobis(1,1'-dibenzyl-3,3'-methylenediimidazolin-2,2'-diylidene)dicopper(I) by varying the benzyl groups to 2,6-diisopropylphenyl and mesityl groups. However, results show that there were difficulties in coordinating these bulkier ligands onto copper. Optimization of complexing bulkier ligands onto copper needs to be conducted before one can proceed onto further reactions.

In the diploma thesis on the complex evaluation of livestock production in the farm with regard to the nutrition and rearing economy of individual categories of cattle, a theoretical and practical part was elaborated. The work was carried out in the company JINOS - AGRO s.r.o., which has animal production focused on breeding Holstein cattle and milk production. The theoretical part of the thesis deals generally with cattle breeding, economy of cattle breeding, animal welfare, bulky feed and compound feed. In the practical part I evaluated the analysis of large feeds, composition and price of feed ration, rearing of individual groups of cattle, milk yield, milk price development and breeding economy. The data obtained in 2014-2018 were evaluated in the thesis.

In this work, I analyzed phase nutrition dairy cattle practiced on a farm. Furthermore, the work focused on quality of bulky feeds from maize silage, grass-clover silage and field bean silage. Feeding method, composition of rations and production parameters were also evaluated, while taking welfare of the animals into account. For data analysis, a nutrition program was used. Indicators of nutritional values and fermentation characteristics, including microbiological testing of silage feeds (maize silage, grass-clover silage, field bean silage), correspond to a very good standard. For maize silage and grass-clover silage, NDV, ADV and NEL values were shown to be slightly below the national average. When evaluating the nutritional level based on the feed ration optimization, we can conclude that the differences in the monitored nutritional values are within the tolerance limits of the recommended values. The level of nutrition corresponds to the production achieved. Fat and starch content of the feed ration are consistent with the recommended values present in literature.

Submitted by Simone Souza (simonecgsouza@hotmail.com) on 2017-08-28T12:57:21Z No. of bitstreams: 1 DISS_2014_Wagner Soares da Costa Junior.pdf: 671389 bytes, checksum: 4cc59c09b13084af673f945baff57103 (MD5) / Approved for entry into archive by Jordan (jordanbiblio@gmail.com) on 2017-08-30T12:15:11Z (GMT) No. of bitstreams: 1 DISS_2014_Wagner Soares da Costa Junior.pdf: 671389 bytes, checksum: 4cc59c09b13084af673f945baff57103 (MD5) / Made available in DSpace on 2017-08-30T12:15:11Z (GMT). No. of bitstreams: 1 DISS_2014_Wagner Soares da Costa Junior.pdf: 671389 bytes, checksum: 4cc59c09b13084af673f945baff57103 (MD5) Previous issue date: 2014-02-25 / CAPES / O experimento foi conduzido para avaliar as perdas por gases e efluente, as características fermentativas e microbiologicas, a composição bromatológica, bem como estimar os parâmetros cinéticos da digestibilidade ruminal in situ de silagens de capim Panicum Maximum Jacq. cv. Tanzânia inoculada com aditivo microbiano-enzimático. Foram testados o feitos de emurchecimento e inoculante, obtendo quatro tratamentos: silagem sem emurchecimento sem inoculante, silagem sem emurchecimento com inoculante, silagem emurchecida sem inoculante e silagem emurchecida com inoculante e três tempo de abertura(40 e 80 dias de ensilagem) e tempo zero sendo a forragem, distribuídos em um delineamento fatorial 2x2x3 inteiramente casualizado com três repetições. Foi feito um corte de uniformização da forrageira, realizado na altura de 30 cm do nível do solo. O capim tanzânia foi ensilado com 45 dias de rebrotação após o corte a 30 cm do solo e a forragem foi ensilada em silos experimentais de 1,3 litros, dotados de uma válvula de sifão e com 600 g de areia adicionados no fundo para retenção dos efluentes. A abertura dos silos ocorreu após 40 e 80 dias. Os dados foram analisadas utilizando o procedimento GLIMMIX do SAS, versão 9.3. Os efeitos principais e interações foram definidos pelo teste-F da ANOVA, sendo o comando SLICEDIFF usado para separar interações significativas. A opção LSMEANS foi utilizada para gerar as médias individuais para cada efeito. Por tratar-se de um fator quantitativo (tempo de abertura), contrastes ortogonais foram utilizados para partição específica dos efeitos de tempo de abertura com umidade e tipo de inoculante. O emurchecimento aumentou o teor de matéria seca de 18,10 para 44,18, mantendo em uma faixa ideal para conservação, melhorou características bromatologicas. Ainda reduziram as perdas por efluente e gás e N-amoniacal das silagens. O uso de inoculante microbiano-enzimático alterou as taxas de perdas por gases e nitrogênio amoniacal, de forma mais evidente em silagens com baixo teor de matéria seca. O inoculante aumentou a contagem lactobacilos nas forragens, diminui a contagem final de levedura e a concentração de acido acético e álcool. O emurchecimento diminui a concentração de acido acético, butírico e lático. Através do emurchecimento e inoculação se obteve o melhor valor de pH (4,54). O emurchecimento da forragem pode ser recomendado como técnicas para ensilagem de capim Tanzânia, pois melhoram a qualidade da silagem ao diminuírem os teores de ácido butírico e acético. O uso de aditivo microbiano-enzimático aliado ao emurchecimento na ensilagem do capim tanzânia, apresentaram o menor valor de pH diminuição. / The experiment was conducted to evaluate losses and effluent gases, fermentation and Microbiological characteristics, chemical composition, and to evaluate the kinetic parameters of in situ ruminal digestibility of grass silages Panicum Maximum Jacq. cv. Tanzania inoculated with microbial-enzyme additive. The inoculant made from wilting and tested, obtaining four treatments: no wilted silage inoculant without silage inoculant with no wilted silage inoculant and wilted without wilted silage inoculant and three time with opening (40 and 80 days of ensiling) and zero time being fodder, distributed in a 2x2x3 factorial design randomized with three replications. One of regrowth forage, held at the height of 30 cm from the ground level was done. Tanzania The grass was ensiled with 45 days of regrowth after cutting 30 cm of soil and forage was ensiled in experimental silos of 1.3 liters, equipped with a valve and siphon with 600 g of sand in the bottom for added retention of effluent. The Silos were opened after 40 and 80 days. Data were analyzed using the SAS procedure GLIMMIX, version 9.3. The main effects and interactions were defined by the F-test of ANOVA, and the command used to separate SLICEDIFF significant interactions. The LSMEANS option was used to generate the individual averages for each effect. Because it is a quantitative factor (opening time), orthogonal contrasts were used to partition the effects of specific opening time with humidity and type of inoculant. Wilting increased the dry matter content of 18.10 to 44.18, keeping in an ideal range for conservation, improved qualitative characteristics. Further reduced effluent losses and gas and ammonia-N silages. The use of microbial-enzyme inoculant shifted exchange losses gases and ammonia nitrogen, most clearly in silages with low content of dry matter. The inoculant increased lactobacilli count in fodder, reduces the final count of yeast and the concentration of acetic acid and alcohol. Wilting reduces the concentration of acetic, butyric and lactic acid. Through wilting and inoculation we got the best pH value (4.54). Wilting the forage can be recommended as techniques for ensiling Tanzania, for improving silage quality by decreasing the levels of butyric and acetic acid. The use of microbial-enzymatic additive combined with wilted grass silage of Tanzania, had the lowest pH value decreased.

[ES] En la presente tesis doctoral se ha llevado a cabo un estudio de nuevas reacciones orgánicas de interés catalizadas por diferentes especies de paladio, tanto clústeres como complejos metálicos. En primer lugar, se ha estudiado la reacción intramolecular regioirregular de Mizoroki-Heck catalizada por clústeres de paladio en disolución, donde se han puesto en conflicto las propiedades electrónicas y estéricas de la reacción de Mizoroki-Heck, obteniendo la reacción de ciclación con una regioselectividad inversa. También se han realizado estudios mecanísticos mediante experimentos cinéticos y computacionales. También se ha desarrollado un catalizador sólido basado en una zeolita, concretamente la zeolita X, que tras intercambiar los cationes de compensación de carga e introducir el Pd, cataliza la reacción intermolecular de Mizoroki-Heck regioirregular. Se ha conseguido obtener un centro activo en la zeolita con las condiciones tanto estéricas como electrónicas óptimas para realizar la reacción intermolecular regioirregular de Mizoroki-Heck entre estirenos y iodobencenos, con buenos rendimientos y selectividades. Por otro lado, se ha estudiado una nueva ruta de síntesis de una fragancia comercial, la deshidromuscona, donde se obtiene un rendimiento global de síntesis mayor que el obtenido actualmente en la industria, todo ello en un menor número de pasos. Se ha llevado a cabo un estudio más intenso sobre el paso donde se realiza la macrociclación en alta concentración, para poder ser viable industrialmente. Mediante la reacción de Mizoroki-Heck estudiada arriba, se ha llevado a cabo un estudio de macrociclación a alta concentración donde, a partir de unos sustratos modelo, se realiza la reacción de macrociclación catalizada por clústeres de paladio en disolución, y se obtienen los macrociclos con buenos rendimientos en una concentración de hasta 1M. También se han realizado estudios mecanísticos tanto computacionales como cinéticos. Por último, se ha realizado la síntesis de dos fosfinas voluminosas basadas en una fragancia, y su posterior estudio de coordinación con el paladio y su alcance catalítico en reacciones orgánicas de interés, como son la telomerización de isopreno, y las reacciones de acoplamiento Buchwald-Hartwig y Suzuki con cloroderivados, donde se comprueba la capacidad catalítica de los complejos formados con nuestras fosfinas y el paladio. / [CA] En la present tesi doctoral s'ha dut a terme un estudi de noves reaccions orgàniques d'interés catalitzades per diferents espècies de pal·ladi, tant clústers com complexos metàl·lics. En primer lloc, s'ha estudiat la reacció intramolecular regioirregular de Mizoroki- Heck catalitzada per clústers de pal·ladi en dissolució, on s'han posat en contrast les propietats electròniques i estèriques de la reacció de Mizoroki-Heck obtenint la reacció de ciclació amb una regioselectivitat inversa. També s'han realitzat estudis mecanístics mitjançant estudis cinètics i computacionals. També s'ha desenvolupat un catalitzador sòlid basat en zeolita, concretament la zeolita X, que després de fer-li intercanvi de cations i introduir el Pd que catalitza la reacció a l'interior, s'ha aconseguit obtindre un centre actiu amb les condicions tant estèriques com electròniques òptimes per a realitzar la reacció intermolecular regioirregular de Mizoroki-Heck entre estirens i iodobencenos amb bons rendiments i selectivitats. D'altra banda, s'ha estudiat una nova ruta de síntesi d'una fragància comercial, la deshidromuscona, on s'obté un rendiment global de síntesi major que l'obtingut actualment en la indústria, tot això en un menor nombre de passos, on s'ha dut a terme un estudi més intens d'un pas on es realitza una macrociclació en alta concentració per a poder ser viable industrialment. Mitjançant la reacció de Mizoroki-Heck estudiada anteriorment, s'ha dut a terme un estudi de macrociclació en alta concentració on a partir uns substrats model es realitza la reacció de macrociclació catalitzada per clústers de pal·ladi en dissolució on s'obtenen els macrocicles amb bons rendiments en una concentració fins del 1M. També s'han realitzat estudis mecanístics tant computacionals com cinètics. Finalment, s'ha realitzat la síntesi de dues fosfines voluminoses basades en fragàncies i el seu posterior estudi de coordinació amb el pal·ladi i el seu abast catalític en reaccions orgàniques difícils, com són la telomerización, la Buchwald-Hartwig o la Suzuki, comprovant la capacitat catalítica dels complexos formats amb les nostres fosfines i el pal·ladi. / [EN] In this doctoral thesis, a study of new organic reactions of interest catalyzed by different palladium species, both clusters and metal complexes, has been carried out. Firstly, the intramolecular regioirregular Mizoroki-Heck reaction catalyzed by palladium clusters in solution has been studied, where the electronic and steric properties of the Mizoroki-Heck reaction have been contrasted, obtaining the cyclization reaction with an inverse regioselectivity. Mechanistic studies have also been carried out by kinetic and computational studies. A solid catalyst based on a zeolite has also been developed, specifically zeolite X, which after making cation exchange and introducing the Pd that catalyzes the reaction inside, it has been possible to obtain an active center with the optimum steric and electronic conditions to carry out the intermolecular regioirregular Mizoroki-Heck reaction between styrenes and iodobenzenes, with good yields and selectivities. On the other hand, a new route for the synthesis of a commercial fragrance, dehydromuscone, has been studied, where a higher overall synthesis yield than the one currently obtained in the industry is obtained. The new synthesis is carried out in less number steps, and a more intense study on the macrocyclization reactive in high concentration has been carried out, in order to evaluate if it is industrially viable. By means of the Mizoroki-Heck reaction studied previously, a study of macrocyclization at high concentration has been carried out where, from some model substrates, the macrocyclization reaction catalyzed by palladium clusters in solution is carried out, to obtain macrocycles with good yields and in a concentration up to 1M. Both computational and kinetic mechanistic studies have also been performed. Finally, the synthesis of two bulky phosphines based on a commercial fragrance and their subsequent coordination with palladium has been studied. Their catalytic scope in challenging organic reactions, such as the telomerization of isoprene, and the Buchwald-Hartwig and Suzuki cross-coupling reactions of chloroderivatives, have been carried out, verifying the catalytic capacity of the complexes formed with our phosphines and palladium. / Garnes Pórtoles, F. (2023). Nuevas reacciones de acoplamiento cruzado de alquenos terminales altamente regioselectivas y catalizadas por paladio [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/195109

Under operational conditions the concept of nutrition and efficiency of milk cows (the breed: Holstein Friesian cattle) was assessed in the chosen agricultural enterprise during the years 2015 and 2016, as well as the production of feed for the milk cows and the economical aspect of milk production during the period of decreasing prices of its purchase. The thesis embodies the assessment of the negative impact of a low rainfall total in the locality of monitored enterprise specialising in the production of bulky feed. Because of this fact the feed amount of productive milk cows were changed in 2016. An interannual decrease of milk yield about 1,92 l per 1 peace of kettle and 1 day was recorded on the grounds of the change of feed doses. The decrease in efficiency and consequently the decrease in delivery of market milk to trade in 2016, together with low prices of purchase of milk, had direct influence on a low economical profits in the area of milk production and milk-cows breeding of the monitored enterprise.

Det kommunala fastighetsbolaget Gavlegårdarna har problem med att hyresgäster lämnar grovavfall i förrådsutrymmen, korridorer och andra allmänna utrymmen. Fastighetsägare ansvarar för att hyresgästerna har möjlighet att sortera ut det avfallsom kommunen ställer krav på, medan hyresgästerna kan hänvisas till återvinningscentralen för att lämna sitt grovavfall. Tillsammans med Gavlegårdarna valdes mångfaldsområdet Öster ut som studieobjekt. Syftet med arbetet är att undersöka psykologiska beteendeteorier som kan förklara människors avfallshantering generellt och avfallshantering i mångfaldsområden specifikt. Enligt the Theory of Planned Behavior formas avsikten till ett beteende av attityder, subjektiva normer och upplevd kontroll. Genom beskrivande information i form av bilder och videomaterial kan den upplevda kontrollen öka, och genom utbildning och moraliska budskap kan de miljövänliga attityderna öka. Genom att öka hyresgästernas miljövänliga attityder minskar beteendekostnaden, som utgörs av en persons attityder gentemot en handling, vägt mot handlingens upplevda kostnad eller ansträngning. För människor nya i det svenska samhället kan bristande kommunikation om hur det nya samhället fungerar bidra till normbrytande beteenden. Samhället behöver därför informera och utbilda, inte bara nysvenskar, utan människor generellt, inom exempelvis avfallshantering. Samtidigt finns stor kunskap hos den nysvenska befolkningen om hur det svenska avfallssystemet upplevs av någon som nyligen behövt anpassa sig till detta. Bostadsområdet Öster ligger 3,2 kilometer från närmaste återvinningscentral, vilket försvårar transporten för de boende i området. Bilinnehavet bland hushållen i området är 37 procent och det är inte tillåtet att ta med sig grovavfall på lokalbussarna. Avståndet utgör en utmaning och därmed bör framtida insamlingsmetod för grovavfall vara fastighetsnära. Då det finns en språkbarriär i Öster bör bild- och videomaterial användas i så stor utsträckning som möjligt, samt muntlig kommunikation när det är möjligt. Av Gavlegårdarnas kundundersökningar framgår att det finns ett engagemang bland hyresgästerna när det kommer till avfallsfrågan. För att involvera hyresgästerna i förändringsprocessen kan Community-based social marketing användas som ramverk. Hyresgästernas upplevda utmaningar och möjligheter gällande grovavfallshantering är viktiga kunskaper i förändringsprocessen och i utformandet av strategier och åtgärder. Oavsett insamlingsmetod bör återbruk ingå, detta för att flytta avfallshanteringen ett steg upp på avfallshierarkin. / The municipal property company Gavlegårdarna is grappling with issues related to tenants improperly disposing of bulky waste in storage areas, corridors, and other public spaces. Property owners are responsible for ensuring that their tenants have the opportunity to sort out the waste that the municipality requires, whilst bulky waste can be directed for the tenants to leave at a recycling center. Together with Gavlegårdarna the diverse neighbourhood Öster was selected as a study object. The work aims to investigate psychological behavioral theories that can explain human waste management in general and waste management in diverse areas specifically. According to the Theory of Planned Behavior, the intention is shaped by attitudes, subjective norms, and perceived behavior control. Through descriptive information in the form of images and video material, the perceived control can increase, and through education and moral messages, environmentally friendly attitudes can increase. By increasing tenants' environmentally friendly attitudes, the behavioral cost is reduced, which consists of a person's attitudes towards an action weighed against the perceived cost or effort of the action. For people new to Swedish society, the lack of knowledge of how the new society works can contribute to norm breaking behaviors. Society, therefore, needs to inform and educate new Swedes in, for example, waste management and at the same time learn from the experiences of the multicultural population. Previous studies have shown that oral communication is common in many cultures and that it can be used as a method to reach out to people new to Sweden. The neighbourhood Öster is 3.2 kilometers away from the nearest recycling center, which makes transport difficult for the residents in the area. Car ownership among households in the area is 37 percent and it is not allowed to bring heavy waste on local buses. The distance poses a challenge and thus the future collection method for bulky waste should be close to the property. As there is a language barrier in Öster, image and video material should be used as much as possible, as well as oral communication whenever possible. Gavlegårdarna's customer surveys show that there is a commitment among tenants when it comes to the waste issue. To involve tenants in the change process, Community-based social marketing can be used as a framework. The tenants' perceived challenges and opportunities regarding bulky waste management are important knowledge in the process of change and the design of strategies and measures. Regardless of the collection method, reuse should be included, to move waste management one step up the waste hierarchy.

The first project in this dissertation presents a simplified and efficient protocol for synthesizing pyrrolines through 5-exo iminyl radical cyclizations. The microwave irradiation of O-Phenyloximes tethered to alkenes causes N-O homolysis resulting in iminyl radical generation, which subsequently undergoes 5-exo-trig cyclizations furnishing pyrrolines. This eliminates the need for toxic radical initiators (AIBN, benzoyl peroxide), propagating agents (Bu3SnH, (Me3Si)3SiH), and expensive catalysts or single-electron transfer (SET) cycles. We explored the scope of diverse traps and substrates for iminyl radical cyclizations. The iminyl radical cyclizations formed versatile pyrrolines with moderate to excellent yields. The diastereoselectivity also ranged from low to high. Moreover, these versatile pyrrolines were further transformed via various reactions, such as hydrogenation, allylation, dihydroxylation, and cross-metathesis. The second part of this project extends the scope of the non-redox iminyl-radical based approach to γ-C(sp3)−H ketone activation. The sequence of N-O homolysis triggered by microwave irradiation of O-phenyloximes, 1,5-hydrogen atom transfer (HAT), trapping of the radical intermediate, and in situ imine hydrolysis, ultimately leads to the formal γ-C–H functionalization of ketones. We achieved both C-O and C-C bond formation by using diverse O-phenyloxime substrates. This work's notable achievement was accomplishing γ-C–H activation of 1o carbon atoms, a feat that has not been attained using SET-based iminyl radical chemistry. The third part of this dissertation focuses on the influence that dehydroamino acids have on secondary structures. This project describes the synthesis of incipient 310 helical tetrapeptides containing dehydroamino acids. A bulky dehydroethylnorvaline-containing tetrapeptide was synthesized. Based on our published data, we speculated that dehydroethylnorvaline might increase peptide proteolytic stability.

No description available.