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1	Studies Toward Yaku'amide A and Synthesis and Applications of Bulky α,β-Dehydroamino Acids Jiang, Jintao 01 July 2016 (has links) Yaku'amide A shows a unique inhibitory profile against a series of 39 human cancer cell lines (JFCR39). In our efforts to synthesize yaku'amide A, we have optimized our regioselective base-free aminohydroxylation method with a series of nitrogen sources, developed a chiral reagent-mediated aminohydroxylation strategy and chemoselective deprotections of the resulting aminohydroxylation product, and explored a stereospecific E2 dehydration and O-N acyl transfer sequence. In addition, we have prepared the right-hand tetrapeptide and the NTA subunit. For our bulky α,β-dehydroamino acids project, we have developed strategies to incorporate α,β-dehydroamino acids such as ΔVal and ΔEnv into small synthetic peptides via Solid Phase Peptide Synthesis (SPPS). We have also prepared two analogues of a monomeric helical peptide with 13 residues. yaku'amide A inhibitory profile chemoselective deprotections stereospecific E2 dehydration right-hand tetrapeptide NTA bulky α β-dehydroamino acids ΔVal and ΔEnv SPPS analogues Chemistry