David Lewis articulated minimal constraints on a formal theory of natural language semantics that have been widely adopted by subsequent theorists: compositionality and sentence truth in a given context. In the process, Lewis distinguished between the compositional semantic value of an expression and its propositional content relative to a context. This dissertation consists of a series of essays in which I address several questions that arise from this distinction, including how we should understand semantic values, how we should understand propositional content, and how we should understand the relation between them. Related to this, I explore and address a number of interesting and unresolved methodological issues that arise in relation to context-sensitivity, and provide an account of the role of speaker intentions in a formal theory of natural language semantics. Additionally, I provide a detailed analysis of the role of context in a theory of natural language semantics and its connection to various aspects of language use and communication. I also motivate coherence with syntactic structure (in the tradition of generative grammar) as an additional constraint on a formal theory of natural language semantics and assess its import for how we theorize about tense and modality and issues related to the syntax-semantics interface, including covert structure and logical form. In broad strokes, this dissertation addresses issues concerning the aims, scope and criteria of a theory of natural language semantics. I approach these issues from the perspective of generative grammar, a theoretical framework that aims to characterize our understanding of natural language independent of its use. These essays help to clarify what should be expected of a formal theory of natural language semantics and its contribution to theories of speech acts and communication.

The purpose of this study was to determine the relationship among career interest profiles as estimated by the Self-Directed Search (SDS), the Strong Campbell Interest Inventory (SCII) and individual's self-estimates (SE). The thesis of this study was that college students can accurately estimate the scores they would receive by taking the SDS and SCII when given only a brief set of instructions. The SDS and SCII were administered to a purposive sampling of 117 college students composed of liberal arts, science, business, engineering and undecided majors from the four undergraduate classes. Information concerning students' socioeconomic background, educational aspirations and career certainty level was gathered in addition to other demographic information. SE, SDS and SCII data were compared using the cluster procedure subprogram of the Statistical Analysis System, and the Spearman rank-order correlation, the Pearson-product-moment-correlation, and the crosstabulation sub-programs of the Statistical Package for the Social Sciences. Comparisons were made between the occupational theme scores derived from SE, SDS and SCII, and between basic interest scale scores obtained from SE and SCII. Occupational theme scores possessed high intercorrelation coefficients across assessment devices. A visual comparison of the intercorrelations among the six themes for each assessment device revealed a strong similarity among the scores produced by each instrument. In addition, high point and secondary, point coding possessed a high degree of interrelationship across assessment methods. The cluster procedure, however, failed to show any relationship among the results of the SDS, SCII or SE theme scores, a finding attributed to an artifact of scaling. SCII basic interest scale scores correlated highly with SE basic interest scale scores, and the cluster analysis procedure supported the correlational findings by showing similarities among SE and SCII basic interest scale dendrograms. In addition, the SE, SDS and SCII scores were descriptively analyzed and compared with one another and with demographic characteristics. Major findings in the study indicate that for college students: 1. SE, SDS and SCII result in similar theme scores and summary codes, and SE and SCII result in similar BIS scores. 2. Students most likely to have SE and inventoried scores in agreement were males from higher socioeconomic backgrounds, possessed higher academic degree ambitions, and showed a high level of agreement between their SE and expressed career goal high point themes. 3. Certainty of career plan, high point career theme, age, academic major, year in college, and grade point average have no relationship with agreement among SE, SDS and SCII scores. 4. College counselors may wish to consider the advantages and limitations of using standardized interest measures since it appears that similar scores can be achieved by asking students to self-estimate their interests. / Ed. D.

This study considers the problem of estimating merchantable volume to some specified top diameter or height limit. The models were separated into two categories. Volume ratio models give the ratios of merchantable to total volume. Taper equations when integrated provide volume estimates of any segment of the bole. Data from plantations and natural stands of loblolly pine were used to compare the models for ability to predict merchantable volumes. Additional evaluations were made among the taper equations to determine the one that "best" describes stem taper. Results showed that different models should be used for different objectives. / Master of Science

Agricultural support levels are at a crossroad with reduced distortions in OECD countries and increasing support for agricultural producers in emerging economies over the last decades. This paper studies the determinants of distortions in the agricultural markets by putting a specific focus on the role of trade policy. Applying various different dynamic panel data estimators and explicitly accounting for potential endogeneity of trade policy agreements, we find that an increase in the number of bilateral free trade agreements exhibits significant short- and long-run distortion reducing effects. By contrast, WTO's Uruguay Agreement on Agriculture has not been able to systematically contribute to a reduction in agriculture trade distortions. From a policy point of view our findings thus point to a lack of effectiveness of multilateral trade negotiations. / Series: Department of Economics Working Paper Series

Au niveau du cerveau et dans le plasma de malades atteints de maladie d’Alzheimer (MA), l’accumulation de C22:0 et d’acides gras à très longue chaîne (C24:0 ; C26:0), la diminution d’acide docosahexaenoique (C22:6 n-3) et les modifications quantitatives et qualitatives de plasmalogènes suggèrent l’implication de dysfonctions peroxysomales. En fonction de ces constatations, les activités biologiques de C22:0, C24:0 et C26:0 ont été recherchées sur des cellules neuronales humaines SK-N-BE. La lipotoxicité des acides gras (C22:0, C24:0 et C26:0) induit divers effets au niveau des mitochondries (modifications topographiques, morphologiques et fonctionnelles), conduit à une rupture de l’équilibre RedOx (surproduction d’espèces radicalaires de l’oxygène, modification de l’activité des enzymes anti-oxydantes : catalase, SOD, GPx), à une peroxydation lipidique et à une désorganisation du cytosquelette (microfilaments d’actine, tubuline, neurofilaments). Ces acides affectent aussi l’amyloïdogenèse et la tauopathie. L’amyloïde béta favorise aussi l’accumulation intracellulaire de C22:0, C24:0 et C26:0. A fortes concentrations, ces acides gras induisent une mort cellulaire non apoptotique. Par ailleurs, les données immunohistochimiques en relation avec l’expression de marqueurs peroxysomaux (ABCD1, ABCD2, ABCD3, ACOX1 et catalase) au niveau du cerveau de souris transgéniques APP PS1 ΔE9 ainsi que les profil d’acide gras obtenus sur le cerveau et le sang de ces souris suggèrent qu’elles pourraient constituer un bon modèle pour l’étude des relations entre MA et métabolisme peroxysomal. L’étude clinique réalisée sur plasma et érythrocytes de malades déments (MA, démences vasculaires, autres démences) montre une forte accumulation de C22:0, C24:0 et C26:0. Le C26:0 pourrait constituer un excellent biomarqueur de la MA. Le C18:0 à est aussi augmenté ainsi que les acides gras n-6. De forts indices de stress oxydant sont aussi révélés. Dans son ensemble, le travail réalisé suggère que les acides gras (C22:0, C24:0 et C26:0) ainsi que le métabolisme des acides gras en relation avec le métabolisme peroxysomal pourraient contribuer à la neurodégénéréscence associée aux démences incluant la MA / In the brain and in the plasma of patients with Alzheimer’s disease (AD), marked accumulation of C22:0 and of very long chain fatty acids (C24:0 ; C26:0) have been reported. Important decreases of docosahexaenoic acid (DHA; C22:6 n-3) have also been described as well as quantitative and qualitative modifications of plasmalogens. Altogether, these lipid modifications suggest an implication of peroxisomal metabolism disorders in the physiopathology of AD. Therefore, the biological activities of C22:0, C24:0 and C26:0 have been studied on human neuronal cells SK-N-BE. On these cells, the lipotoxicity of fatty acids (C22:0, C24:0 and C26:0) leads to various cellular modifications: topographical, morphological and functional changes at the mitochondrial level, rupture of RedOx equilibrium (overproduction of reactive oxygen species, modification of the activity of enzymes involved in anti-oxidant defenses: catalase, SOD, GPx), lipid peroxidation, cytoskeleton disorganization (actin microfilaments, tubulin, neurofilaments). These fatty acids also favor amyloidogenesis and tauopathy. At elevated concentrations, these fatty acids trigger a non apoptotic mode of cell death. Moreover, data obtained by immunohistochemistry with antibodies raised against peroxisomal components (ABCD1, ABCD2, ABCD3, ACOX1 and catalase) on histological tissue sections of the brain of transgenic mice APP PS1 ΔE9 as well as lipidomic analysis performed on the blood and the brain of these mice suggest that they could constitute interesting model to study the relationships between AD and peroxisomal metabolism. The clinical study performed on the plasma and on the erythrocytes of patients with dementia (AD, vascular dementia, other dementia) revealed an important accumulation of C22:0, C24:0 and C26:0. Hexacosanoic acid (C26:0) might constitute an excellent biomarker of AD. The fatty acid C18:0 and (n-6) fatty acids have also been found at increased concentrations. A strong oxidative stress has also been revealed. Altogether, our data support that the fatty acids (C22:0, C24:0 and C26:0) as well as the fatty acid metabolism depending on the peroxisome might contribute to neurodegeneration leading to various types of dementia including AD

The Church was not the only progenitor and disseminator of ideas in medieval England, but it was the most pervasive. Relations between the ecclesiastical and lay realms are well documented at high social levels but become progressively obscure as one descends to the influence of the Church at large on society at large (and vice versa). The twelfth century was a time of great energy and renewal in the leadership and scholarship of the Church; comparable religious energy and renewal can be seen in late-medieval lay culture. The momentum was passed on in the thirteenth century, and pastoral care was the means of its transfer. The historical sources in this field tend to be either prescriptive, such as treatises on how to hear confessions, or descriptive, such as bishops’ registers. Prescription and description have generally been addressed separately. Likewise, the parish clergy and the friars are seldom studied together. These families of primary sources and secondary literature are brought together here to produce a more fully-rounded picture of pastoral care and church life. The Church was an inherently local institution, shaped by geography, personalities, social structures, and countless ad hoc solutions to local problems. Few studies of medieval English ecclesiastical history have fully accepted the considerable implications of this for pastoral care; close attention to local variation is a governing methodology of this thesis, which concludes with a series of local case studies of pastoral care in several dioceses, demonstrating not only the divergences between them but also the variations within them.

This work describes the application of a variety of Lewis bases, encompassing predominantly N-heterocyclic carbenes (NHCs), but also the use of imidazoles, aminopyridines, amidines and isothioureas, as effective catalysts in the dearomatisation of heterocyclic carbonates, predominantly the rearrangement of oxazolyl carbonates to their C-carboxyazlactone isomers by means of the Steglich rearrangement. This rearrangement reaction has been investigated extensively, with the development of simplified reaction procedures and the invention of domino cascade protocols incorporating this transformation. In an attempt to understand the mechanism of this O- to C-carboxylation process, a number of interesting observations have been made. Firstly, the class of NHC has an important factor in promoting the rearrangement, with triazolinylidenes being the most effective. Secondly, an interesting chemoselectivity has been delineated using triazolium-derived NHCs, prepared using weak bases (typically Et₃N) or strong metallated bases; both alkyl and aryl oxazolyl carbonates undergo smooth rearrangement with triazolinylidenes derived from strong metallated bases such as KHMDS, while only aryl oxazolyl carbonates undergo rearrangement using Et₃N. Extensive effort has focused towards the development of asymmetric variants of these protocols, primarily towards the design, synthesis and evaluation of chiral NHC precatalysts. To this end, a number of chiral azolium salts have been prepared, encompassing a number of different NHC classes, including C₁- and C₂-imidazolinium salts, C₂-imidazolium salts and a range of triazolium salts. Efforts towards the asymmetric catalysis of the Steglich rearrangement of oxazolyl carbonate substrates have given an optimal 66% ee. Similar rearrangements have been demonstrated with the related furanyl heterocyclic substrate class, producing a mixture of α- and γ-carboxybutenolides. In contrast to the analogous oxazolyl carbonates, the regioselectivity of this rearrangement is dependent upon the nature of the Lewis base employed. Amidines and aminopyridines give a mixture of the α- and γ- regioisomers with generally the α-regioisomer being preferred, while a triazolium-derived NHC gives rise to predominantly the thermodynamically more stable γ-carboxybutenolide. Using amidines or aminopyridines, this rearrangement has been shown to proceed via an irreversible C-C bond-forming process, but in contrast, the rearrangement using the NHC proceeds via an equilibrium process with an optimised regioselectivity of >98:2 for the γ-carboxybutenolide regioisomer over the α-regioisomer. Whilst the asymmetric variant using chiral NHCs has proven unfruitful, rearrangements using a chiral isothiourea have given high levels of regioselectivity towards the α- regioisomer and with excellent levels of enantiodiscrimination (77–95% ee).

Au niveau du cerveau et dans le plasma de malades atteints de maladie d'Alzheimer (MA), l'accumulation de C22:0 et d'acides gras à très longue chaîne (C24:0 ; C26:0), la diminution d'acide docosahexaenoique (C22:6 n-3) et les modifications quantitatives et qualitatives de plasmalogènes suggèrent l'implication de dysfonctions peroxysomales. En fonction de ces constatations, les activités biologiques de C22:0, C24:0 et C26:0 ont été recherchées sur des cellules neuronales humaines SK-N-BE. La lipotoxicité des acides gras (C22:0, C24:0 et C26:0) induit divers effets au niveau des mitochondries (modifications topographiques, morphologiques et fonctionnelles), conduit à une rupture de l'équilibre RedOx (surproduction d'espèces radicalaires de l'oxygène, modification de l'activité des enzymes anti-oxydantes : catalase, SOD, GPx), à une peroxydation lipidique et à une désorganisation du cytosquelette (microfilaments d'actine, tubuline, neurofilaments). Ces acides affectent aussi l'amyloïdogenèse et la tauopathie. L'amyloïde béta favorise aussi l'accumulation intracellulaire de C22:0, C24:0 et C26:0. A fortes concentrations, ces acides gras induisent une mort cellulaire non apoptotique. Par ailleurs, les données immunohistochimiques en relation avec l'expression de marqueurs peroxysomaux (ABCD1, ABCD2, ABCD3, ACOX1 et catalase) au niveau du cerveau de souris transgéniques APP PS1 ΔE9 ainsi que les profil d'acide gras obtenus sur le cerveau et le sang de ces souris suggèrent qu'elles pourraient constituer un bon modèle pour l'étude des relations entre MA et métabolisme peroxysomal. L'étude clinique réalisée sur plasma et érythrocytes de malades déments (MA, démences vasculaires, autres démences) montre une forte accumulation de C22:0, C24:0 et C26:0. Le C26:0 pourrait constituer un excellent biomarqueur de la MA. Le C18:0 à est aussi augmenté ainsi que les acides gras n-6. De forts indices de stress oxydant sont aussi révélés. Dans son ensemble, le travail réalisé suggère que les acides gras (C22:0, C24:0 et C26:0) ainsi que le métabolisme des acides gras en relation avec le métabolisme peroxysomal pourraient contribuer à la neurodégénéréscence associée aux démences incluant la MA